ISSN:
1420-908X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract When activated in autologous mixed leukocyte reactions (auto-MLR)in vitro, T cells from normal individuals produce a suppressor factor(s) which inhibits the Epstein-Barr virus (EBV)-induced proliferation of normal B cells. In contrast, T cells from patients with rheumatoid arthritis (RA) are deficient in their ability to generate this suppressor factor in auto-MLR. Addition of tilomisole (Wy-18,251; 3-(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid) to the auto-MLR (0.1–100 μg/ml) did not alter the production of suppressor activity by normal T cells, but 100 μg/ml tilomisole restored to normal the defective factor production by RA T cells. Indomethacin (1 μg/ml) but not levamisole (0.1–100 μg/ml) had a similar effect, which suggests that the action of tilomisole in this system is due to its ability to inhibit prostaglandin biosynthesis. Nonetheless, the ability of tilomisole to down-regulate B cell function may contribute to the compound's antiarthritic activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01966486
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