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  • 1985-1989  (19)
  • 1
    Electronic Resource
    Electronic Resource
    A comparison of propofol and midazolam by infusion to provide sedation in patients who receive spinal anaesthesia (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 43 (1988), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Twenty patients scheduled for orthopaedic surgery under spinal anaesthesia received by intravenous infusion either 1% propofol or 0.1% midazolam at a rate adjusted to maintain adequate sedation as judged on a five-point scale. No other anaesthetic or analgesic drugs were given. The mean time to reach the required level of sedation was similar in both groups and the quality and ease of control of sedation were good in all patients. Mean infusion rates were 3.73 mg/kg/hour for propofol and 0.27 mg/hg/hour for midazolam. Airway maintenance was excellent and there were no side effects other than restlessness of the arms in one patient in each group. Recovery, judged by ability to open the eyes and recall date of birth, was significantly more rapid after propofol than after midazolam (2 and 10 minutes respectively after the end of infusion) and two patients in the latter group were unduly drowsy in the initial postoperative period. Pre- and postoperative amnesia were greater in the midazolam group but no patient had recall of peri-operative events. Psychometric tests showed significantly better recovery of higher mental function after propofol for up to 2 hours after surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1988.tb09084.x
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  • 2
    Electronic Resource
    Electronic Resource
    Propofol for induction of anaesthesia in children (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 43 (1988), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The induction characteristics, dosage requirements, cardiovascular and respiratory effects of propofol with added lignocaine were compared with those of thiopentone and halothane inhalational induction in two groups of children aged 1–5 years and 5–10 years. Propofol induction produced significantly greater decreases in blood pressure, particularly in the 1–5-year age group. Heart rate was maintained well with all three induction techniques. Pain on injection into a vein on the dorsum of the hand was significantly more common with propofol despite the addition of lignocaine. However, this was mild in the majority of children and did not interfere with the induction of anaesthesia. The incidence of respiratory depression and other adverse effects was low with all three induction methods. The mean induction doses of both intravenous agents were greater in the 1–5-year age group. The ratio of thiopentone to propofol dose was approximately 2.5:1 in both age groups. The high incidence of pain on injection with propofol may prove to be a significant drawback to its otherwise satisfactory use in children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1988.tb09010.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Persistent pneumothorax treated with continuous positive airway pressure (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 42 (1987), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A patient who presented with persistent pneumothorax after blunt chest trauma is described. The lung re-expanded partially in response to chest drain suction but some areas remained collapsed. The institution of continuous positive airway pressure on an intermittent basis, was followed by complete re-expansion of the lung and resolution of the pneumothorax.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1987.tb05372.x
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  • 4
    Electronic Resource
    Electronic Resource
    Propofol for intravenous sedation (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 42 (1987), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study investigated the properties of propofol when given by subanaesthetic infusion to provide sedation as an adjunct to spinal anaesthesia for lower limb surgery in 40 patients. Sedation, defined as sleep with preservation of eyelash reflex and purposeful reaction to verbal or mild physical stimulation, was satisfactorily achieved and maintained with minimal complications. The mean duration of infusion was 98 minutes and a mean infusion rate of 3.0 mg/kg/hour was required in patients over 65. This was significantly less (p 〈 0.005) than the 4.1 mg/kg/hour required in younger patients. Recovery was impressively rapid; patients regained full consciousness approximately 4 minutes after the end of infusion, and were free from minor postoperative sequelae. Conversion to general anaesthesia was achieved in three patients where surgery encroached outside the analgesic field of the regional block, simply by increasing the infusion rate to approximately 10 mg/kg/hour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1987.tb02936.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Delayed convulsions following enflurane anaesthesia (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 41 (1986), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A case of convulsions which occurred 3 days after recovery from enflurane anaesthesia is reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1986.tb12746.x
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  • 6
    Electronic Resource
    Electronic Resource
    Drug dilution in anaesthetic practice (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 40 (1985), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The accuracy of dilution by anaesthetists of commonly used drug preparations was assessed by ultra violet spectrophotometric assay of the diluted drugs. Percentage deviation from target concentrations was then calculated. Of a total of 358 drug dilutions carried out by 28 anaesthetists only 58% were within 10% of the target concentration while 6% lay outside 50% of the target concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1985.tb10760.x
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Continuous subcutaneous infusion of morphine for postoperative pain relief (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 40 (1985), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A double-blind randomised study of 48 patients in whom continuous subcutaneous infusion and regular intramuscular injection of morphine were compared as analgesic regimens after upper abdominal surgery, is described. Over a 48-hour period, no difference in pain intensity between the two groups was found by comparing linear analogue scores, assessments on a four-point rank scale, peak expiratory flow rates or requirement for additional analgesia. Nausea and sedation were assessed using a four-point rank scale. These side effects were less frequent with subcutaneous infusion (p〈0.05). Two patients from each group were judged to have received an overdose. The infusion apparatus was simple and convenient to use. Continuous subcutaneous infusion of morphine is a practical and effective means of achieving postoperative analgesia but, as with other mandatory dosing regimens, relative overdosage may occur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1985.tb10607.x
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  • 8
    Electronic Resource
    Electronic Resource
    Decay properties of the new proton-rich nucleus104Sn: Mass determinations beyond the proton drip line (1985)
    Springer
    The European physical journal 321 (1985), S. 599-603 
    Details
    ISSN: 1434-601X
    Keywords: 23.40.Hc ; 21.10.Dr ; 29.30.Kv
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The new proton-rich nucleus104Sn was produced in a50Cr(58Ni, 2p2n)104Sn reaction. Its half-life was measured to be 21±1s. From a newly established partial decay scheme, aQ EC value of 4,000 −300 +650 keV was estimated. The resulting mass excess value for104Sn, combined with decay energies for α and proton emission, leads to mass excess values for the nuclei108Te,109I,112Xe, and113Cs. These mass values are compared to predictions of mass formulae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01432436
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Profound reduction in morphine clearance and liver blood flow in shock (1986)
    Springer
    Intensive care medicine 12 (1986), S. 366-369 
    Details
    ISSN: 1432-1238
    Keywords: Critical care ; Sedatives ; Morphine ; Indocyanine green
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In six patients with septic shock apparent liver blood flow was significantly reduced compared with two patients restudied on recovery from shock and a group of four matched unshocked patients undergoing intensive care (287±23 ml/min vs 870±164 ml/min; mean±SEM). In the shocked patients the elimination half-life of morphine was significantly prolonged (13.2±3.5 h vs 5.9±1.4 h; mean±SEM) and the systemic clearance of morphine reduced by 53%, in comparison with the non-shocked patients. In both groups, morphine elimination was markedly delayed compared with previously reported observations in normal subjects and surgical patients. Care should be exercised with the use of drugs with a high hepatic extraction ratio in shocked patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00292927
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Deformation in the light Br isotopes (1988)
    Springer
    Hyperfine interactions 43 (1988), S. 481-488 
    Details
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The nuclear ground state spins of the odd-A Br nuclides75, 77, 79Br with Z=35 are all 3/2−. Nilsson orbital calculations show that the 35th proton occupies the f5/2 [301]3/2− orbital for ε〈0.20 and the p3/2 [312]3/2− orbital at larger deformations. The magnetic moments of these two states differ by a factor of two, giving clear evidence for the magnitude of the ground state deformation. Low Temperature Nuclear Orientation measurements made in Oxford and Bonn on76, 77gBrFe prepared at ISOLDE, and on line at the SERC Daresbury Laboratory on72, 74m, 75BrFe, have yielded the magnetic moments of these isotopes, using a two non-zero field model with magnetic hyperfine fields of +81.38(6) T and 26(2) T. The spin of the73Br ground state is also deduced. An interpretation of the ground state configurations of these isotopes is given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02398329
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