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  • 1
    Electronic Resource
    Electronic Resource
    CHANGES IN NUCLEAR DNA IN NORMAL AND ASCITES TUMOR CELLS (1956)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 63 (1956), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1956.tb50895.x
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  • 2
    Electronic Resource
    Electronic Resource
    Discriminating Power of Rodent Deoxyribonucleic Acid on Incubation in Agar (1966)
    [s.l.] : Nature Publishing Group
    Nature 211 (1966), S. 486-490 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE discovery1 that denatured deoxyribonucleic acid (DNA) from higher organisms can be trapped in an agar gel, and used to combine specifically with DNA fragments from similar or different sources, enabled the genetic approach, pioneered by Doty and his group2 in bacteria, to be extended to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/211486a0
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  • 3
    Electronic Resource
    Electronic Resource
    Fractionation of Mouse Deoxyribonucleic Acid on Hydroxyapatite (1965)
    [s.l.] : Nature Publishing Group
    Nature 208 (1965), S. 1175-1179 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] WE have been examining the ability of various fractions of mouse DNA to form specific duplexes with homologous or heterologous DNA in agar1'2. One particularly convenient method of obtaining fractions which differ either in their degree of secondary structure or in their base composition is by the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2081175a0
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  • 4
    Electronic Resource
    Electronic Resource
    Rewards for Inventors (1971)
    [s.l.] : Nature Publishing Group
    Nature 231 (1971), S. 357-359 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Professor Walker describes two contrasting personal experiences as an inventor and suggests that inventors should be encouraged to participate much more fully during the period of translation of an idea into a commercial ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/231357a0
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  • 5
    Electronic Resource
    Electronic Resource
    Origin of Satellite DNA (1971)
    [s.l.] : Nature Publishing Group
    Nature 229 (1971), S. 306-308 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The mystery of how satellite DNA came to be so widespread in plants and animals could be solved if this DNA conferred an advantage on the chromosome which carried it. This advantage might be an improved ability to stand up to the rigours of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/229306a0
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  • 6
    Electronic Resource
    Electronic Resource
    Correspondence of Certain Fractions of Mouse DNA (1969)
    [s.l.] : Nature Publishing Group
    Nature 221 (1969), S. 771-772 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In particular, we coined the terms "stable" and "labile"6 to describe the two fractions which elute respectively in high and low salt (that is, in the native position and in the single stranded position) when denatured fragments of mouse DNA are eluted from a hydroxyapatite column at constant ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/221771a0
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  • 7
    Electronic Resource
    Electronic Resource
    How Different are the DNAs from Related Animals? (1968)
    [s.l.] : Nature Publishing Group
    Nature 219 (1968), S. 228-232 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The differences between the DNAs of various animal species present considerable evolutionary ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/219228a0
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  • 8
    Electronic Resource
    Electronic Resource
    Variations in the DNA from Two Rodent Families (Cricetidae and Muridae) (1970)
    [s.l.] : Nature Publishing Group
    Nature 225 (1970), S. 915-919 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Even within a closely related family, the banding profiles in CsCl and reassociation rates of the DNA exhibit considerable ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/225915a0
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  • 9
    Electronic Resource
    Electronic Resource
    The development of resistance to methotrexate in a mouse melanoma cell line (1979)
    Springer
    Chromosoma 74 (1979), S. 153-177 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract PG19T3 mouse melanoma cells were selected for resistance to methotrexate. Nine sub-lines that are resistant to concentrations of methotrexate ranging from 1.27×10−7 M, to 1×10−4M methotrexate were selected and characterised in terms of their content of dihydrofolate reductase activity and their chromosomes. The intracellular level of dihydrofolate reductase activity increases with increasing resistance such that at the highest level of resistance PG19T3:MTXR 10−4 M cells contain approximately 1,000 fold more enzyme activity than the parental PG19T3 cells. It is shown that the enhanced activity is due to an increase in the amount of the enzyme rather than any structural change to the enzyme in resistant cellls. Comparisons of pH activity profiles, profiles under different activating conditions and titrations with methotrexate suggest that the sensitive and resistant cells contain identical dihydrofolate reductases. Analysis of the chromosomes of resistant cells shows the presence of up to 5 large marker chromosomes which contain homogeneously staining regions after G-banding. These same regions stain intensely after C-banding and fluoresce brightly after staining with Hoechst 33258. The size of homogeneously staining regions increases throughout the process of selection. For one marker chromosome this increase may have been mediated via a ring chromosome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00292270
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  • 10
    Electronic Resource
    Electronic Resource
    Optical isotope shifts of146Sm and151Sm (1984)
    Springer
    The European physical journal 318 (1984), S. 243-244 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We have measured the optical isotope shifts of146Sm and151Sm by laser resonance fluorescence. From these measurements the changes in the mean square nuclear radii are: Δ〈r2〉 (A=144 to 146)=0.266(10) fm2, and Δ〈r2〉 (A=151 to 152)=0.262(10) fm2. These results, together with those of the stable isotopes, show that the average nuclear expansion of samarium can be accounted for by the liquid drop model with deformations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01413476
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