ISSN:
1619-7089
Keywords:
SeHCAT
;
B12-inflammatory bowel disease
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The absorption of 75Se-23-selena-25-homotaurocholate (SeHCAT) was compared with vitamin-B12 absorption and conventional radiography in 44 patients with inflammatory bowel disease. The retention of SeHCAT was normal in 11 patients with ulcerative colitis but was abnormally low in 9 patients with terminal-ileal resection, 9 out of 14 patients with small-bowel Crohn's disease and in 2 out of 10 patients with Crohn's colitis. The 5 patients with small-bowel Crohn's disease and normal retention had either inactive disease or no radiological evidence of terminalileal involvement. Measurements of the absorption of vitamin B12 did not discriminate between these groups, and there was very poor correlation between B12 and SeHCAT absorption (r=0.506, P〈0.05). There was extremely good correlation of SeHCAT retention measured using a whole-body counter with that measured using an uncollimated gamma camera (r=0.96, P〈0.001). The results suggest that SeHCAT retention may prove complementary to conventional methods of assessing small-bowel disease in patients with inflammatory bowel disease. As measurement by gamma camera is feasible, this test can be used in most departments of nuclear medicine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00252746
Permalink
