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  • 1
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In situ hybridization with 35S-labeled single stranded RNA probes was used on sections from formaldehyde-fixed and paraffin-embedded tissue specimens to provide semiquantitative data on the occurrence of transthyretin(TTR)-mRNA in human liver, choroid plexus and pancreatic islets as well as in 15 endocrine tumours of the pancreas and gut. A monoclonal antibody to TTR was used for immunocytochemical identification of the protein in consecutive sections. The amount of TTR-mRNA in hepatocytes was found to be much less than that in epithelial cells of the choroid plexus. Glucagon cells of the pancreatic islets were also specifically labeled and the level of TTR-mRNA in these cells was intermediate between that of hepatocytes and choroid plexus epithelial cells. Four glucagonomas, one malignant insulinoma and two midgut carcinoids were shown to contain TTR-mRNA. The ‘in situ’ labeled cells were also found to be TTR immunoreactive. These findings present the first conclusive evidence for TTR synthesis in pancreatic islets and in endocrine tumours. They also establish that the high serum concentration of TTR found in some patients with endocrine tumours (notably glucagonomas) is most likely due to tumour production of TTR.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric radiology 17 (1987), S. 459-462 
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The size of a kidney, as measured on a urogram, is a sensitive indicator of renal damage in a child with urinary tract infection and renal surface area correlates well with glomerular filtration rate. Sequential measurements can be invaluable in evaluating the efficacy of a regimen of treatment. A system utilizing a personal microcomputer has been developed to facilitate the measuring procedure and the handling and analysis of data.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    International orthopaedics 11 (1987), S. 311-313 
    ISSN: 1432-5195
    Keywords: Ostearthritis ; Hip ; Aetiology ; Labour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Pour savoir si les contraintes extérieures peuvent contribuer au déveleloppement de la coxarthrose, on a interrogé au sujet de leur métier 85 malades atteints de coxarthrose primitive ainsi que 262 malades urologiques masculins. L'importance de l'atteinte de leurs hanches a été appréciée sur les radiographies. Les malades présentant une coxarthrose avaient exercé plus fréquemment des travaux de force, avec soulèvement de poids lourds et pour beaucoup conduite de tracteurs. Nos résultats montrent que les efforts entraînés par les modes de vie et les métiers divers peuvent jouer un rôle dans l'apparitation de la coxarthrose.
    Notes: Summary To investigate whether environmentally associated stress may contribute to the development of coxarthrosis, 85 males with primary coxarthrosis and 262 male urological patients were questioned about their occupation, and their hips were graded radiologically. Patients with coxarthrosis had been more frequently exposed to heavy labour, heavy lifting, and much tractor driving. Our results indicate that environmentally associated stress, as reflected by a varied life style or occupation, may contribute to the development of coxarthrosis.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    International orthopaedics 9 (1985), S. 235-237 
    ISSN: 1432-5195
    Keywords: Femoral head viability ; Femoral neck fractures ; Fracture displacement ; impaction ; Osteoporosis ; osteosynthesis ; Reoperation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Ce travail compare deux groupes de malades présentant une fracture du col du fémur: 22 ayant dû être réopérés et 72 non. On a particulièrement étudié l'ostéoporose, le redéplacement de la fracture, la vitalité de la tête fémorale, la réduction avec compression peropératoire et le type d'ostéosynthèse: par un clou de Thornton ou trois broches de Scand. On a mis en évidence une différence significative (p〈0.01) entre les deux groupes en ce qui concerne l'ostéoporose, le redéplacement de la fracture et la vitalité de la tête du fémur. Les broches de Scand comparées aux clous de Thornton ont montré une tendance (p〈0.1) à déterminer moins de réinterventions. La compression ou l'absence de compression peropératoire n'ont entraîné aucune différence.
    Notes: Summary This investigation compares two groups of patients with fractures of the femoral neck: 22 required a further operation and 72 did not. Special attention was paid to osteoporosis, the displacement of the fracture, viability of the femoral head, operative impaction and osteosynthesis with a Thornton nail or three Scand hip pins. There was a significant (p〈0.01) difference between the two groups with regard to osteoporosis, fracture displacement and viability of the femoral head. Scand hip pins, as compared to Thornton nails, showed a tendency (p〈0.1) to need a smaller number of reoperations. Operative impaction compared with no impaction showed no difference.
    Type of Medium: Electronic Resource
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