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  • 1
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ten human kidney specimens and thirty-two renal cell carcinomas were investigated for the presence of transthyretin mRNA and cystatin C mRNA using Northern blot analysis. Five of ten kidney specimens and 15 of 32 renal carcinomas were also immunohistochemically investigated for the presence of the corresponding proteins. Transthyretin mRNA could not be detected in any of the normal or neoplastic tissue preparations, whereas low amounts of cystatin C mRNA were found in nine of ten normal kidneys and in 24 of 32 renal cell carcinomas. Immunoreactive transthyretin and cystatin C were present in proximal tubular epithelial cells of all kidney specimens, whereas neither of the proteins was detected in the tumour cells of the renal carcinomas. Immunoreactive cystatin C was, however, demonstrated in scattered monocyte/macrophage-like cells. We conclude that the presence of immunoreactive transthyretin and cystatin C in proximal tubular cells of the kidney is most likely due to reabsorption of the proteins from the primary urine. The small amounts of cystatin C mRNA in some of the normal and neoplastic renal preparations are probably due to cystatin C synthesis in macrophages. Transthyretin has been recommended as an immunohistochemical marker for renal cell carcinomas. Our results, however, clearly indicate that neither transthyretin nor cystatin C constitutes a useful marker for such neoplasms.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Molecular and Cellular Cardiology 16 (1984), S. 16 
    ISSN: 0022-2828
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0022-2828
    Keywords: Adenylate cyclase ; Carbachol ; Muscarinic receptors ; Oxotremorine ; Phosphatidylinositol
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0022-2828
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0375-9474
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    International orthopaedics 9 (1985), S. 235-237 
    ISSN: 1432-5195
    Keywords: Femoral head viability ; Femoral neck fractures ; Fracture displacement ; impaction ; Osteoporosis ; osteosynthesis ; Reoperation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Ce travail compare deux groupes de malades présentant une fracture du col du fémur: 22 ayant dû être réopérés et 72 non. On a particulièrement étudié l'ostéoporose, le redéplacement de la fracture, la vitalité de la tête fémorale, la réduction avec compression peropératoire et le type d'ostéosynthèse: par un clou de Thornton ou trois broches de Scand. On a mis en évidence une différence significative (p〈0.01) entre les deux groupes en ce qui concerne l'ostéoporose, le redéplacement de la fracture et la vitalité de la tête du fémur. Les broches de Scand comparées aux clous de Thornton ont montré une tendance (p〈0.1) à déterminer moins de réinterventions. La compression ou l'absence de compression peropératoire n'ont entraîné aucune différence.
    Notes: Summary This investigation compares two groups of patients with fractures of the femoral neck: 22 required a further operation and 72 did not. Special attention was paid to osteoporosis, the displacement of the fracture, viability of the femoral head, operative impaction and osteosynthesis with a Thornton nail or three Scand hip pins. There was a significant (p〈0.01) difference between the two groups with regard to osteoporosis, fracture displacement and viability of the femoral head. Scand hip pins, as compared to Thornton nails, showed a tendency (p〈0.1) to need a smaller number of reoperations. Operative impaction compared with no impaction showed no difference.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    International orthopaedics 11 (1987), S. 311-313 
    ISSN: 1432-5195
    Keywords: Ostearthritis ; Hip ; Aetiology ; Labour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Pour savoir si les contraintes extérieures peuvent contribuer au déveleloppement de la coxarthrose, on a interrogé au sujet de leur métier 85 malades atteints de coxarthrose primitive ainsi que 262 malades urologiques masculins. L'importance de l'atteinte de leurs hanches a été appréciée sur les radiographies. Les malades présentant une coxarthrose avaient exercé plus fréquemment des travaux de force, avec soulèvement de poids lourds et pour beaucoup conduite de tracteurs. Nos résultats montrent que les efforts entraînés par les modes de vie et les métiers divers peuvent jouer un rôle dans l'apparitation de la coxarthrose.
    Notes: Summary To investigate whether environmentally associated stress may contribute to the development of coxarthrosis, 85 males with primary coxarthrosis and 262 male urological patients were questioned about their occupation, and their hips were graded radiologically. Patients with coxarthrosis had been more frequently exposed to heavy labour, heavy lifting, and much tractor driving. Our results indicate that environmentally associated stress, as reflected by a varied life style or occupation, may contribute to the development of coxarthrosis.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-198X
    Keywords: Key words Females ; Urinary tract infection ; Renal scarring ; Vesicoureteral reflux ; Follow-up
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We report the detection and progression of renal scars in girls prospectively followed from their first recognized urinary tract infection. There were 107 infection-prone subjects with a median age of 7.1 years at the first and 21.7 years at the last urography. Of 51 females who ultimately had lesions, 38 had established scars at the first urography. In 18 subjects, new scars were found in previously undamaged kidneys, 5 already with unilateral scarring. There had been a normal urography after the 5th birthday in 8 of those with later scarring. Worsening of scarring was seen in 10 of the 38 subjects with established scars. The renal damage was in most cases slight or moderate. By stepwise logistic regression analysis, grade of reflux and number of pyelonephritic attacks correlated with scarring, and number of pyelonephritic attacks with new scars and worsening of the lesions. In summary, of the females who ultimately had renal lesions, one-third developed new scars. In most of those with established scars at the first urography, the focal character of lesions suggests that most were also acquired. Since reflux and number of pyelonephritic attacks were identified as risk factors, prevention of renal deterioration should be possible.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric radiology 1 (1973), S. 96-99 
    ISSN: 1432-1998
    Keywords: Children ; catheterisation ; adverse effects-thrombosis-atrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thirty-three 6 month to 13 year (average 9 years) old children subjected to femoral artery catheterisation in the 1960s were reviewed 2–9 years (average 5 years) later. They were then 7–18 years old (average 14 years). The review included measurement of the circumference of each calf and oscillography. Of the patients in whom either of these methods had suggested obstruction of the circulation, 10 were selected at random and examined with plethysmography and/or arteriography. The relatively high frequency of impaired circulation and growth of the limb found, appeared to warrant the conclusion that vascular catheterisation of children should always be followed by careful investigation for vascular obstruction, preferably with oscillography, and, if thrombosis is suspected by supplementary arteriography. A firm diagnosis of thromboembolism after catheterisation with occlusion of a major limb artery motivates thromboectomy.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric radiology 17 (1987), S. 459-462 
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The size of a kidney, as measured on a urogram, is a sensitive indicator of renal damage in a child with urinary tract infection and renal surface area correlates well with glomerular filtration rate. Sequential measurements can be invaluable in evaluating the efficacy of a regimen of treatment. A system utilizing a personal microcomputer has been developed to facilitate the measuring procedure and the handling and analysis of data.
    Type of Medium: Electronic Resource
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