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  • 1
    Electronic Resource
    Electronic Resource
    Synthesis and antiinflammatory activities of 3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-ones (1987)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 30 (1987), S. 1995-1998 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00394a011
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  • 2
    Electronic Resource
    Electronic Resource
    Some aspects of doping mechanism in Polyschwefelnitrid (SN)x (1985)
    Springer
    Colloid & polymer science 263 (1985), S. 631-637 
    Details
    ISSN: 1435-1536
    Keywords: Polysulphurnitride ; halogen doping ; multiple diffraction ; grain boundary
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract (SN)x crystals doped with iodine atoms showed ten or more additional diffuse streaks perpendicular to the b*-axis, appearing between the layer lines of the electron diffraction pattern of pristine (SN)x. However, only four of these were observed in the X ray diffraction pattern. These four diffuse streaks suggest that the iodine atoms are structured with a one-dimensional order. The extra diffuse streaks can be explained by the double diffraction between the four streaks and the spotty diffractions of (SN)x. The double diffraction results from the microfibrillar nature of the (SN)x. From X-ray microanalysis of doped (SN)x, the iodine content in the specimen was found to change mainly in the direction along the chain axis and almost constant in the direction perpendicular to it. The distribution of iodine atoms indicates that the dopants diffuse preferentially along the molecular axis through disordered domains between fine fibrils comprised in (SN)x crystals. Then the dopants are settled in the narrow disordered domains and give the extra streaked diffraction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01419887
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  • 3
    Electronic Resource
    Electronic Resource
    Thickening process of polyethylene single crystals at an early stage of annealing (1985)
    Springer
    Colloid & polymer science 263 (1985), S. 293-300 
    Details
    ISSN: 1435-1536
    Keywords: Polyethylene single crystal ; annealing ; thickening ; computer simulation ; small angle X-ray scattering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The thickening process of polyethylene single crystals was simulated with computer by the Monte Carlo method. According to the experimental results in the previous report, the time dependence of the long period changed greatly with annealing temperature; at lower temperatures the long period increased gradually, while at high temperatures the long period rapidly increased at a very early stage of annealing and then increased gradually after passing through a plateau. Through computer simulation, it was shown that such a great change in the time dependence of the long period with annealing temperature can be explained by combining two mechanisms: (A) sliding diffusion of molecular segments along the chain axis and (B) local melt-recrystallization (namely, local melting followed by recystallization).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01412244
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  • 4
    Electronic Resource
    Electronic Resource
    Pharmacological properties of N-methoxy-3-(3,5-ditert-butyl-4-hydroxybenzylidene)-2-pyrrolidone (E-5110), a novel nonsteroidal antiinflammatory agent (1987)
    Springer
    Inflammation research 21 (1987), S. 250-252 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The antiinflammatory activity of a novel pyrrolidone derivative E-5110 was investigated using anti-inflammatory, analgesic and antipyretic animal models in comparison to indomethacin (IND) and piroxicam (PIR). The acute antiinflammatory activity of E-5110 on carrageenin paw edema was similar to IND, and half of PIR. E-5110 inhibited the pleural exudate volume and leucocyte infiltration in a reversed passive Arthus reaction more potent than IND. The chronic inflammatory responses in the established adjuvant- and type II collagen-induced arthritis were suppressed by E-5110 similar to IND and PIR. The analgesic potency of E-5110 was similar to IND and PIR, but the antipyretic activity of E-5110 was more potent than that of IND, and slightly more potent than that of PIR. The ulcerogenic effect of E-5110 on rat gastric mucosa was less than that of the reference drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966481
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  • 5
    Electronic Resource
    Electronic Resource
    In vitro effect of N-methoxy-3-(3,5-ditert-butyl-4-hydroxybenzylidene)-2-pyrrolidone (E-5110), a novel nonsteroidal anti-inflammatory agent, on generation of some inflammatory mediators (1987)
    Springer
    Inflammation research 21 (1987), S. 269-271 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cultured rat synovial cells generate PGE2 upon stimulation with a factor derived from rate polymorphonuclear cells (Prostaglandins27, 697, 1984). E-5110 inhibited PGE2 generation by the synovial cells. The IC50 values (μM) for inhibition of PGE2 generation were 0.026 for E-5110, 0.008 for indomethacin, 0.112 for piroxicam, 0.003 for R-830, 0.667 for BW-755C and 2.05 for benoxaprofen. Calcium ionophore A-23187-stimulated LTB4 generation by human neutrophils was inhibited by E-5110 with an IC50 value of 0.20 μM, which was similar to NDGA. The inhibition of LTB4 by E-5110 was more potent than that of R-830, BW-755C or benoxaprofen. E-5110 also inhibited superoxide generation by human neutrophils stimulated with opsonized zymosan, f-Met-Leu-Phe and phorbol myristate acetate. These results indicate that E-5110 is a potent dual inhibitor that suppresses superoxide generation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966487
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  • 6
    Electronic Resource
    Electronic Resource
    Inhibitory effects of E-5110 on interleukin-1 generation from human monocytes (1989)
    Springer
    Inflammation research 27 (1989), S. 322-324 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Effects of E-5110, a novel non-steroidal antiinflammatory drug, on interleukin-1 (IL-1) generation from human monocytes were studiedin vitro. E-5110 reduced the amounts of extra- and intracellular IL-1 activity induced by lipopolysaccharide (LPS, 1 μg/ml) in a dose-dependent manner (1–10μM). E-5110 also inhibited the IL-1 generation induced by antigen-antibody complexes, opsonized zymosan and silica particles. It was suggested that the inhibition of IL-1 generation by E-5110 was independent of the inhibitory effects on arachidonate cyclooxygenase and/or lipoxygenase because indomethacin, piroxicam, BW755C and AA861 had no effects on IL-1 generation. Hydrocortisone (IC50:0.084 μM), aurothioglucose (11.5 μM) and lobenzarit (75.0 μM), which are clinically effective antirheumatic drugs, also inhibited IL-1 generation, like E-5110 (1.21 μM). It is expected that E-5110 will be superior to classical non-steroidal antiinflammatory drugs in medical treatment of rheumatoid arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972811
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  • 7
    Electronic Resource
    Electronic Resource
    Interleukin-1-like activity in the exudate of air-pouch inflammation in rats, and its participation in granuloma formation (1989)
    Springer
    Inflammation research 27 (1989), S. 359-360 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thein vivo production of lymphocyte activating factor (LAF) activity was investigated in the exudate of the rat air-pouch inflammation model. An inflammatory reaction was induced by lipopolysaccharide (LPS) injection into the air-pouch, and the time course of LAF activity in the exudate was investigated. LAF activity in the exudate reached a peak by 6 h, and rapidly decreased at 10 to 48 h after the LPS injection. Dexamethasone revealed strong inhibitory action on LAF activity and granuloma formation. On the other hand, indomethacin could not inhibit either of the phenomena. In conclusion, LAF (IL-1) is rapidly produced after the onset of inflammation and may participate in the subsequent granuloma formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972822
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  • 8
    Electronic Resource
    Electronic Resource
    The circulating α1-antitrypsin-elastase complex attacks the elastic lamina of blood vessels (1988)
    Springer
    Histochemistry and cell biology 88 (1988), S. 443-451 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The aim of the study was to determine the destination of the α1-antitrypsin-elastase complex, which is found in circulating blood after the peroral administration of elastase. The complex was made in vitro by mixing hog pancreatic elastase with human α1-antitrypsin and then injected intravenously into rats and mice. Tissues taken at various times after injection were subjected to histochemical staining using an antibody against elastase. Light micro-scope observations revealed dense deposition of reaction products in the elastic lamina of the arterioles; moderate or slight deposits were seen in the tissues surrounding arteries, in the tubular epithelial cells of the proximal convoluted tubules in the kidney, and in the pancreatic ducts.Immuno-electron microscopy revealed heavy deposition of the reaction product in the elastic lamina of the small arteries and arterioles; some dissolution of the elastic fibers was also evident. Pinocytic uptake of the α1-antitrypsin-elastase complex was observed on the abluminal surface of endothelial cells and in smooth-muscle cells bordering the elastic lamina of arterioles. The endothelial cells of the arteries and arterioles retained their normal morphological appearance, although local desquamation was observed in some animals. The results indicate that, when the α1-antitrypsin-elastase complex is present in the circulating blood, it is incorporated into the elastic lamina through the endothelial layer. This results in liquefaction of the lamina, desquamation of endothelial cells and leakage of the complex into the perivascular tissues via the vascular walls. However, some of the complex seems to be excreted very quickly from the kidneys.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00570307
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  • 9
    Electronic Resource
    Electronic Resource
    Short-term use of gonadotropin-releasing hormone agonist (Leuprolide) for in vitro fertilization (1988)
    Springer
    Journal of assisted reproduction and genetics 5 (1988), S. 332-334 
    Details
    ISSN: 1573-7330
    Keywords: gonadotropin-releasing hormone (GnRH) agonist ; in vitro fertilization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A common problem encountered by in vitro fertilization (IVF) programs is the premature occurrence of the spontaneous lutenizing hormone (LH) surge during ovarian stimulation cycles. Administration of gonadotropin-releasing hormone agonists (GnRH-a) for 2 to 3 weeks produces a state of hypogonadotropic hypogonadism, thus allowing ovarian stimulation to proceed uncomplicated by a spontaneous LH surge. We have elected to treat seven patients with GnRH-a in a “short-term” protocol, with GnRH-a initiated on cycle day 3 along with exogenous gonadotropins. In this series, we found that the spontaneous LH surge was abolished, while ovarian responsiveness seemed to be improved. These results suggest that the initial surge of gonadotropins elicited by GnRH-a administration may enhance ovarian stimulation and that spontaneous LH surge is blocked when GnRH-a and exogenous gonadotropins are initiated concomitantly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01129568
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