ISSN:
1432-0711
Keywords:
Anticoagulation
;
Dihydroergotamine
;
Pulmonary embolism
;
Thrombosis
;
Hysterectomy
;
Intraoperative blood loss
;
Postoperative blood loss
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The antithromboembolic efficacy of once a day low molecular weight heparin in fixed combination with dihydroergotamine (LMWH-DHE) was compared with conventional heparin-DHE in combination with Acenocoumarol (heparin-DHE/A) in 191 patients undergoing gynaecological surgery. LMWH-DHE proved equally effective in preventing thromboembolic complications, with a similar incidence of postoperative bleeding and side effects. Deep vein thrombosis occurred once in each group and one non-fatal pulmonary embolism occurred in the LMWH-DHE group. The main advantage of LMWH-DHE was significantly better patient acceptance of the single daily subcutaneous injection as compared with the two injections of conventional heparin-DHE (P=0.02). On the other hand, LMWH-DHE was associated with significantly increased incidence of intraoperative bleeding (P〈0.02). The bleeding did not, however, cause any clinical problems. Discontinuation of therapy due to bleeding or pain at the site of injection occurred three times in each group. We consider the use of LMWH-DHE to be an attractive, economic and safe method of thromboembolic prophylaxis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00931291
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