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  • 1
    Electronic Resource
    Electronic Resource
    Changes in dopamine receptor sensitivity in humans after heavy alcohol intake (1985)
    Springer
    Psychopharmacology 86 (1985), S. 142-146 
    Details
    ISSN: 1432-2072
    Keywords: Alcohol ; Withdrawal ; Dopamine receptors ; Growth hormone ; Apomorphine test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dopamine (DA) sensitivity, assessed through maximal growth hormone (GH) response to stimulation by apomorphine (APO) (0.18–0.24 mg iv) was studied in 16 chronic alcoholics newly admitted after a period of heavy alcohol intake. Repeated hormonal tests were thereafter performed during a 2-month period under strictly controlled conditions to avoid relapse into alcohol consumption. Eight healthy volunteers with alcohol consumption slightly less than that of the general population were used as controls. It was found that DA sensitivity in the early abstinence phase was higher than later in the 2-month recovery period but not significantly different from control values. The relatively higher DA sensitivity in the early abstinence phase might be responsible for a lower threshold for psychotic symptoms and neuroleptic-induced extrapyramidal side effects. The results of this study give further evidence of a prolonged recovery phase after heavy alcohol intake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431699
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Low serum cobalamin levels in a population study of 70- and 75-year-old subjects (1989)
    Springer
    Digestive diseases and sciences 34 (1989), S. 716-723 
    Details
    ISSN: 1573-2568
    Keywords: vitamin B12 ; aged ; population study ; atrophic gastritis ; postgastrectomy state ; megaloblastic anemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined causes and hematological consequences of low serum cobalamin (vitamin B 12)concentration in two representative population samples of 70- year-old (N=293) and 75- year- old subjects (N=486). Subjects with values below 130 pmol/liter (4.8% and 5.6%, respectively) were investigated with Schilling test, upper gastrointestinal endoscopy, determination of serum gastrin and group I pepsinogens, and bone marrow examination. Gastrointestinal abnormalities of etiologic significance were found in 26 of the 32 examined subjects: atrophy of the gastric body mucosa (N=16, with pernicious anemia in six), partial gastrectomy (N=6), and intestinal malabsorption (N=4). Megaloblastic hematopoiesis was found in 10 individuals, four of whom had macrocytic anemia. Our results indicate that low serum cobalamin concentration in the elderly is usually a consequence of disease rather than of high age per se and that gastric mucosal atrophy is a major etiologic factor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01540343
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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