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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 51 (1986), S. 109-111 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: A pharmacological study was undertaken to determine whether the noradrenaline-stimulated breakdown of inositol phospholipids and the potentiation of isoprenaline-stimulated cyclic AMP by noradrenaline in rat cerebral cortex slices are mediated by the same α-receptor subtype. The rank order of potency of a range of α1 and α2 antagonists suggests that both responses may involve an α1 receptor, but there were several differences between the pharmacological profiles for the two systems. Although in both cases, all selective α1 antagonists were more potent than α2 antagonists, the rank orders and the absolute potencies differed for the two responses. The inhibition of the inositol phosphate response was characterised by a high α1/α2 antagonist ratio, and in most cases, Hill slopes of inhibition were consistent with the involvement of a single receptor site. Inhibition of the cyclic AMP response had a much lower α1/α2 antagonist ratio and generally exhibited Hill slopes less than one. Evidence has been provided suggesting that adenosine is involved in the potentiation of cyclic AMP and that other, as yet unidentified, factors may also be involved. Even in the absence of an adenosine component, the results presented support the suggestion that the potentiation due to noradrenaline is mediated by a receptor whose identity does not easily fit with the currently accepted classification of α adrenoceptors.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 56 (1985), S. 1015-1017 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The TFTR Thomson scattering system has been operational since January 1984. The diagnostic uses two ruby lasers and two spectrometer-detector systems to provide profiles at two times in a discharge. The two scattering lines consist of 76 spatial channels which span the 200-cm vacuum vessel along a major radius. The detectors are gated, intensified CCD arrays with single photoelectron sensitivity. Te(R) and Ne(R) profiles are presented.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 59 (1988), S. 2235-2240 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We describe a powerful picosecond KrF* laser system consisting of a synchronously pumped dye oscillator, a three-stage dye amplifier, frequency conversion to 248 nm, and amplification through a series of excimer modules. Characteristics are given at each stage of the system. With the first stage of the system complete, a focused intensity of ∼1016 W/cm2 is obtained. Initial visible spectra obtained by interaction with various targets are presented.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: X-ray diffraction and absorption spectroscopy provide complementary structural tools for the in situ characterization of electrode surfaces. To optimize surface sensitivity, techniques such as glancing angle scattering geometries and spectrum differencing can be employed while the application of synchrotron radiation allows the real-time collection of data. This paper outlines recent developments in in situ electrochemistry on the Daresbury SRS and describes an electrochemical cell for in situ x-ray studies, associated glancing angle instrumentation, together with computer hardware and software optimized for data acquisition using potential modulation techniques. Important fundamental and industrial applications are highlighted.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 12 (1985), S. 0 
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Twenty-one specimens of Verruca vulgaris were used for an investigation to define what portion of the papillomatous structures seen in H & E stain will correspond to Che areas of positive staining for pupilloma virus antigen utilizing the peroxidase-antiperoxidase immunostaining technique. Vacuolar spaces filled with thready material and large ovoid parakeratotic cells seen in H & E stain stained positively for papilloma virus antigen. In the granular layer, viral antigens stained heavily, the nuclei of cells showing koilocytosis. Both round and irregularly shaped kerathohyaline granules did not stain positively for viral antigen stain. Eight of the 21 specimens showed marked positivity for papilloma virus antigen. Three other cases were positive in only focal sites. Of the 8 immunostained-positive selected cases used for ultrastructural studies, only 2 showed the viral particles. The study suggests that the PAP immunostaining is a more sensitive and yet less cumbersome method than electronmicroscopy for demonstration of papilloma virus
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 86 (1987), S. 1340-1347 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Overtone vibration-laser double resonance measurements determine the vibrational relaxation rates of DF(v=1) and HF(v=1) by the DF dimer. Both monomers are efficiently relaxed by the dimer at a rate that is 20% of the gas kinetic rate. The similarity of the rate constants for the two systems, which have very different energy defects, indicates that the relaxation occurs by collision complex formation and energy redistribution, rather than direct vibration-to-vibration energy transfer from the monomer to the dimer.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 83 (1985), S. 1132-1137 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Overtone vibration–laser double resonance measurements determine the vibrational relaxation rate of HF(v=1) by HF dimers. Vibration-to-vibration energy transfer from the excited monomer to the dimer followed by vibrational predissociation of the dimer provides an efficient pathway for vibration-to-translation energy transfer that deexcites the monomer at 40% of the gas kinetic collision rate. Analysis of the pressure dependence of the observed decay constants using a simple kinetic model establishes a rough upper limit of 10 ns on the predissociation lifetime of the collisionally excited dimer.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 84 (1986), S. 220-226 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Overtone vibration-laser double resonance directly measures the relative importance of vibration-to-vibration and vibration-to-translation-and-rotation energy transfer for HF(v=3 and v=4) at room temperature. The fraction of HF(v) molecules relaxing by V–V energy transfer is 0.44±0.05 and 0.16±0.05 for v=3 and v=4, respectively, compared to 0.59±0.10 for v=2. These measurements show that V–T,R energy transfer is the dominant relaxation mechanism for HF(v≥3) and the observed decreased amount of V–V energy transfer for higher initially excited vibrational levels is in good agreement with a chemiluminescence measurement and several theoretical calculations. The data demonstrate that the magnitude of the energy defects for the component pathways primarily determines the energy transfer mechanism for HF(v=2–4).
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 82 (1985), S. 780-788 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The temperature dependencies of the total self-relaxation rate constants for the vibrational deactivation of HF(v=2) and HF(v=1) and the state-to-state vibration-to-vibration (V–V) and vibration-to-translation-and-rotation (V-T,R) energy transfer components of the HF(v=2) self-relaxation process are measured using the overtone vibration excitation-laser double resonance technique. The total self-relaxation rate constants vary inversely with temperature. The much weaker temperature dependence of HF(v=2) self-relaxation compared to that of HF(v=1) arises from the significant role of the V–V energy transfer route. Competition between energetics and collision duration results in a weaker inverse variation with temperature for the slightly endothermic V–V route than for the exothermic V-T,R route for HF(v=2). The branching ratio for V–V energy transfer increases slightly with temperature and the data suggest that two quantum relaxation processes constitute no more than 10% of the total self-relaxation of HF(v=2). The available temperature dependence data on self-relaxation of HF(v=1–5) form a consistent picture in which the energetics of the V–V and V-T,R relaxation pathways control their relative contributions to the total energy transfer.
    Type of Medium: Electronic Resource
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