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  • 1985-1989  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Characterization of Two Morphologically Distinct Leu-7+ Cell Subsets with Respect to Leu-15 Antigen (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 23 (1986), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: in the present study the fine structures of Leu-7-Leu-15+ and Leu-7+-Leu-15 cell subpopulations were characterized by using an immunogold-immunoperoxidase double labelling in electron microscopy. The densities of Leu-15 antigenic sites on both E rosetting (Er) and non-adherent/non-E rosetting (non-A/non-Er) Leu-15 positive cell surfaces were also evaluated by using an immunogold analysis in electron microscopy. A majority of Leu-7+ cells co-expressed I he Leu-15 antigen and showed an ultrastructural pattern specific for mature natural killer (NK) cells, i.e. abundant cytoplasm with many organelles. numerous electron dense granules and irregular outline. On the other hand, a minority of Leu-7- ceils did not express the Leu-15 antigen and showed a clearly different ultrastructural feature in comparison to Leu-7+-Leu-15+ cells T hus, the presence of the Leu-15 antigen on Leu-7 + cell surface corresponds to ultrastructural features specific to differentiated NK cells and may represent an expression of Leu-7+cell differentiation. An alternative hypothesis may he that Leu-7+-Leu-15- and l.eu-7-Leu 15 cells represent distinct cell lineages within non-A/non-Er Leu-7+ cells. Finally, the results of the present study provide proof that Leu-7+ antigen is more frequently represented on non-A/non-Er Leu-L-15+ cells than on Er Leu-15+ cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1986.tb01961.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Leu-7-positive cells with monocyte phenotype show different ultrastructural features in comparison to Leu-7-positive cells with T-cell phenotype (1985)
    Springer
    Histochemistry and cell biology 82 (1985), S. 525-527 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The ultrastructural features of the Leu-7-positive — Leu-M3-positive cell subpopulation and the Leu-7-positive — Leu-4-positive cell subpopulation were characterized and compared using immunogold-immunoperoxidase double labelling with immunoelectron microscopy. The majority of Leu-7-positive cells coexpressed a monocyte phenotype and showed an ultrastructural pattern specific for functional natural killer (NK) cells, i.e. a low nuclear/cytoplasmic (N/C) ratio, an irregular outline, many cytoplasmic organelles and electron-dense granules. In contrast, only a minority of Leu-7-positive cells coexpressed a T phenotype, and these were characterized by a high N/C ratio, an even surface and the absence of electron-dense granules. Thus, Leu-7-positive — Leu-4-positive cells may by an immature form of NK cells, and Leu-7-positive—Leu-4-positive and Leu-7-positive — Leu-M3-positive cell subpopulations may represent different stages of Leu-7-positive cell differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00489973
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Immune response to cytomegalovirus in patients with acquired-immunodeficiency syndrome related complex (ARC) and AIDS (1987)
    Springer
    European journal of epidemiology 3 (1987), S. 439-441 
    Details
    ISSN: 1573-7284
    Keywords: AIDS ; Cytomegalovirus ; AIDS-related complex ; Human-Tlymphotropic retrovirus type III
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was undertaken with the aim of elucidating the mechanisms underlying the cell-mediated immunodeficiency seen in the acquired immunodeficiency syndrome (AIDS). An intrinsic functional defect in the in vitro surviving T lymphocytes from patients with AIDS has been described. This defect is reflected by profound reductions in both the cloning efficiency of these cells and in the number of precursor cells for response to lectins. Since many patients affected by AIDS present active cytomegalovirus (CMV) infections and impairment in CMV-specific cellular immunity, we examined the number of CMV-specific precursor cells in patients affected by the AIDS-related complex (ARC), who had serum antibodies to CMV and to the human-T-lvmphotropic retrovirus-type III (HTLV-III), recently termed human immunodeficiency virus (HIV). Their responses were compared to those of patients with AIDS and to those of healthy-CMV-seropositive and HTLV-III seronegative controls. We detected a significant reduction of precursors for cell-mediated immune response to CMV in AIDS, in comparison to normal controls and a reduction in ARC, even if not significant. In parallel, we assayed the response to phytohemoagglutinin, which was maintained in ARC and depressed in AIDS. Our results show a defect of specific cell-mediated immunity to CMV in ARC and AIDS patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00145659
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    Paper (German National Licenses)
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