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  • 1
    Electronic Resource
    Electronic Resource
    A unique two-electron, reversible reduction of a binuclear copper(II) complex. Observation of the electrochemical behavior predicted by Polcyn and Shain for the sequential transfer of two electrons at the same potential (1978)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 100 (1978), S. 1931-1932 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00474a052
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  • 2
    Electronic Resource
    Electronic Resource
    Concentration of digoxin, methyldigoxin, digitoxin and ouabain in the myocardium of the dog following coronary occlusion (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 287 (1975), S. 399-411 
    Details
    ISSN: 1432-1912
    Keywords: Glycosides ; Coronary Occlusion ; Myocardial Concentration ; Epicardial Electrocardiogram
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 26 mongrel dogs were given a single dose of 0.03 mg/kg tritium-labelled digoxin, β-methyldigoxin, digitoxin or ouabain 2 hrs or 95 hrs following experimental coronary occlusion. Examination of the epicardial ECG was performed by moving from intact to ischemic or necrotic zones. 60 min after glycoside administration the animals were sacrificed and tissue samples from the marked heart muscles areas and from the skeletal muscle were analysed for glycoside content. The early glycoside uptake in acute ischemic or necrotic myocardium was diminished independently of the physicochemical properties of the glycoside. Significantly higher glycoside concentrations (ng/g wet weight) were measured in the injured myocardium 3 hrs after coronary occlusion than 96 hrs afterward (p〈0.005). The values in acute ischemic myocardium varied considerably. This non-homogeneity of glycoside uptake in the acute ischemic heart muscle may partly explain the increased sensitivity to glycosides in myocardial infarction. The decline of glycoside concentration correlates with the alterations in the epicardial ECG. The cardiac effects of cardenolides 60 min after intravenous administration was caused by the unchanged glycoside. In contrast to the myocardium, glycoside accumulation could not be found in the skeletal muscle. The concentrations of digoxin, β-methyldigoxin and digitoxin in the skeletal muscle were significantly higher than the concentration of ouabain, which was rapidly eliminated via the urine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500041
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  • 3
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1980)
    Springer
    Journal of molecular medicine 58 (1980), S. 53-54 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477147
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  • 4
    Electronic Resource
    Electronic Resource
    Vergleichende hämodynamische Untersuchungen über die extrarenale Wirkung von Furosemid und Ethacrynsäure (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 1133-1134 
    Details
    ISSN: 1432-1440
    Keywords: Furosemide ; ethacrynic acid ; haemodynamic ; Furosemid ; Ethacrynsäure ; Hämodynamik
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 12 Patienten (1–4 Monate nach akutem Myocardinfarkt) wurde das Verhalten hämodynamischer Parameter in Ruhe und unter Belastungsbedingungen vor und nach i.v. Injektion von Furosemid und Ethacrynsäure untersucht. Herzzeitvolumen, Herzfrequenz und arterieller Druck zeigen nach Applikation von Furosemid und Ethacrynsäure keine signifikanten Veränderungen. Während nach Injektion von Ethacrynsäure (trotz gleich starker Diurese wie nach Furosemid) eine gerichtete Veränderung des diastolischen Pulmonalarteriendruckes (PA d) und rechten Vorhofdruckes (RA) nicht zu beobachten ist, bewirkt Furosemid bereits wenige Minuten nach Applikation eine signifikante Senkung des linksventriculären Füllungsdruckes (PA d) und des rechten Vorhofdrucks (RA). Diese hämodynamischen Veränderungen sind als Folge eines direkten dilatorischen Effektes von Furosemid auf die Kapazitätsgefäße aufzufassen. Eine entsprechende direkte Gefäßwirkung von Ethacrynsäure ist nicht nachzuweisen.
    Notes: Summary The haemodynamic effects of intravenous injections of furosemide and ethacrynic acid were studied in 12 patients during rest and excercise. Cardiac output, heart rate and arterial blood pressure showed no significant changes after injection of furosemide or ethacrynic acid. Few minutes after injection of furosemide there were significant falls of pulmonary artery diastolic pressure and right atrial pressure, whereas no changes were seen after injection of ethacrynic acid. This initial effect of furosemide apparently is of primarily vascular origin, causing an increased peripheral venous capacitance. Ethacrynic acid failed to exhibit any direct vascular effect
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01614283
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  • 5
    Electronic Resource
    Electronic Resource
    1-Aminocyclopropane-1-carboxylic acid — a new intermediate of ethylene biosynthesis (1979)
    Springer
    Naturwissenschaften 66 (1979), S. 264-265 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00571611
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  • 6
    Electronic Resource
    Electronic Resource
    Schalenelemente in gemischer Darstellung: Theorie — Kritik — Beispiele (1978)
    Springer
    Archive of applied mechanics 47 (1978), S. 207-222 
    Details
    ISSN: 1432-0681
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Summary To analyse thin shell structures curved mixed elements are developed and studied from a theorctical vantage point and through the medium of numerical exampels. The investigations show, that the accuracy of mixed shell elements is dependent first of all on the choice of integration variables, while the influence of the order of polynoms is less.
    Notes: Übersicht Zur Berechnung dünnwandiger Schalen wird ein Satz von gekrümmten Elementen mit Ansatzfreiwerten in gemischter Weg- und Kraftgrößendarstellung entwickelt und deren Brauchbarkeit an Hand einiger Beispiele überprüft. Die theoretischen und numerischen Untersuchungen zeigen, daß die Genauigkeit gemischter Elemente in erster Linie von der Auswahl geeigneter Integrationsvariabler abhängt, während die Ordnung der Polynomansätze die Approximationsgüte nur geringfügig beeinflußt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00536408
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  • 7
    Electronic Resource
    Electronic Resource
    Vergleichende Studien über Bau und Funktion des Amnions (1955)
    Springer
    Anatomy and embryology 119 (1955), S. 7-22 
    Details
    ISSN: 1432-0568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Wir ergänzten unsere bereits 1953 veröffentlichten Untersuchungen am Amnion des Menschen durch einige neue Befunde. Im Epithel des Amnions wird die Entwicklung der sog. “Kolossalzellen” beschrieben (Abb. 2a und b und Abb. 3). Im Bindegewebe wurden die verschiedenen Zonen: 1. Die Basalmembran (Abb. 4); 2. die locker gebaute Fibrocytenzone (Abb. 6 und 8b); 3. das fischschwarmähnliche, später sich auflockernde Fibrocytenmaschenwerk (Abb. 8a); 4. die gitterfaserige Verschiebeschicht (Stratum intermedium) (Abb. 9) genauer in ihren Entwicklungsstadien analysiert. Außerdem wurden diese Zonen durch eine Stufenphotographie (Abb. 8a-c) näher erläutert. Erstmalig wurden in allen Bindegewebszonen des Amnions die sog. Hofbauerzellen nachgewiesen und ihr Gestaltwandel beschrieben. Sie wurden auf Grund der verschiedenen Erscheinungsformen als “histiocytäre freie Wanderzellen” charakterisiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00529404
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  • 8
    Electronic Resource
    Electronic Resource
    Medulloblastoma: Survey of factors possibly influencing the prognosis (1982)
    Springer
    Acta neurochirurgica 64 (1982), S. 215-224 
    Details
    ISSN: 0942-0940
    Keywords: Medulloblastoma ; histological variants ; biological behaviour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a series of 310 cases the role of the factors age, sex, location of the tumour (midline or lateral), and medulloblastoma type (classic or desmoplastic) were analysed with regard to the prognosis. The influence of therapy is not considered because of the inhomogeneity of the material and the view nowadays that treatment is insufficient. The occurrence of lateral (or hemispheric) medulloblastomas increases in the group of the 11–15 years old patients. The proportion of the desmoplastic type is greater in adults than in children, but they are distributed almost equally medially and laterally. There seems to be no definite correlation between sex and the survival time. The mean survival time increases with age. With regard to the histological subclassification into children and adults, the mean survival times are nearly identical. The only obvious factor with a decisive influence on the prognosis seems to be the time of appearance of the tumour. Additionally, the data support the conclusion that a desmoplastic medulloblastoma should be considered as a histological variant without clinical relevance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01406054
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  • 9
    Electronic Resource
    Electronic Resource
    Supratentorial recurrences of gliomas. Morphological studies in relation to time intervals with astrocytomas (1977)
    Springer
    Acta neurochirurgica 37 (1977), S. 75-91 
    Details
    ISSN: 0942-0940
    Keywords: Supratentorial astrocytomas ; Recurrences of astrocytomas ; Classification of gliomas ; Recurrence intervals ; Radiotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report 137 recurrent supratentorial astrocytomas. The primary tumours diagnosed on the basis of a grading system with three stages were 72 astrocytomas I and 65 astrocytomas II. In the first group 14% of the recurrences were not changed, 55.5% became astrocytomas II, and 30.5% became glioblastomas. In the second group 55.4% were unchanged, and 44.6% became glioblastomas. The postoperative intervals until reintervention or death were statistically examined. It seems that the recurrence time chiefly depends on the nature of the primary tumour. The transformation of an astrocytoma I to a glioblastoma takes longer than the transformation of an astrocytoma II into a glioblastoma. In about two thirds of all astrocytomas an increase of malignancy is to be expected. From the histological picture it is not possible in an individual case to predict the likelihood or speed of malignant change. With regard to the effect of irradiation the authors conclude that radiotherapy most probably does not produce malignancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401927
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  • 10
    Electronic Resource
    Electronic Resource
    Supratentorial recurrences of gliomas. Results of reoperations on astrocytomas and oligodendrogliomas (1978)
    Springer
    Acta neurochirurgica 43 (1978), S. 217-227 
    Details
    ISSN: 0942-0940
    Keywords: Astrocytomas ; supratentorial ; oligodendrogliomas ; supratentorial ; recurrent gliomas ; reoperation ; radiotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary On the basis of our previous investigation regarding histological transformation of recurrent astrocytomas and oligodendrogliomas we report the clinical results of reoperations. The present observations deal with 121 cases: grade 1 astrocytomas (45), oligodendrogliomas (12), grade 2 astrocytomas (47), and oligodendrogliomas (17), respectively. In all these a second reoperation was performed in 14 cases. Operative mortality was relatively high, but without significant difference in the two groups of malignancy: 24.5% and 29.6%. Survival times in both groups showed striking individual differences. We achieved post-reoperation survivals exceeding one year in 18 and 14 cases, respectively. The results of second reoperations were generally poor. We find no remarkable differences in survival time following reoperations in primary grade 1 and grade 2 tumours. Similarly, malignant change proved to be not decisive for survival times. On the contrary, most of our patients with unchanged grade 1 astrocytomas, reoperated on after a longer interval, achieved a short second survival only. Prolongation of life expectancy by radiotherapy is doubtful. Irradiation seems to be necessary with malignantly transformed tumours if the patient did not have any treatment before reoperation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01587957
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