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  • 1
    Electronic Resource
    Electronic Resource
    A comparative study of the effects of aspirin and paracetamol (acetaminophen) on platelet aggregation and bleeding time (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 567-571 
    Details
    ISSN: 1432-1041
    Keywords: aspirin ; paracetamol ; plasma aspirin esterase activity ; bleeding time ; platelet aggregation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a double blind, randomised trial, the effects of 1 g aspirin and 1 g paracetamol were compared on bleeding time and platelet aggregation in 40 volunteers (20 females). Also investigated was the relationship between plasma aspirin esterase activity and both bleeding time and platelet aggregation after aspirin. Following 1 g aspirin there was a significant increase in bleeding time at 24 h (p〈0.01). A significant reduction (P〈0.01) in platelet aggregation with collagen was observed at 1, 6 and 24 h after aspirin, but no significant reduction (P〉0.05) was observed with ADP. Paracetamol had no effect on bleeding time or platelet aggregation. Plasma aspirin esterase activity ranged from 0.26–0.6 µmol/ml/min. A significant negative correlation (R=−0.55, P〈0.001) was observed between percentage increase in bleeding time (24 h) and plasma aspirin esterase activity. Further significant correlations were observed between plasma aspirin esterase activity and change in platelet aggregation with collagen at 1 h (R=0.68, P〈0.001), 6 h (R=−0.73, P〈0.001) and 24 h (R=−0.67, P〈0.001). These results suggest that it might be possible to predict an individual's haemostatic response to aspirin from knowledge of their plasma aspirin esterase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543486
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  • 2
    Electronic Resource
    Electronic Resource
    Structure of the deoxytetranucleotide d-pApTpApT and a sequence-dependent model for poly(dA-dT)Supplementary material on observed and calculated structure factors for d-pApTpApT is available from the authors. (1982)
    New York : Wiley-Blackwell
    Biopolymers 21 (1982), S. 513-533 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The x-ray structure of the hydrated ammonium salt of the deoxytetranucleotide d-pApTpApT was determined by Patterson and direct methods at a resolution of 1 Å. The crystal structure contains right-handed double-helical segments formed by complementary Watson-Crick-type hydrogen bonding between the adenine and thymine bases of neighboring molecules. The minihelix contains two base pairs. The chains are antiparallel. The A-T and T-A sequences have different phosphodiester conformations. The deoxyribose-pucker and the sugar-base orientation alternate along the chain depending on the nature of the base (3′-endo for purine and 2′-endo for pyrimidine). The extended structure is stabilized by base-base, base-sugar, and hydrogen-bond interactions. The minihelix of two base pairs provides starting coordinates for model-building studies of the dA-dT polymer. A B-DNA-type polymer structure is described, which has sequence-dependent alternations of both the deoxyribose pucker and the phosphate diester bridge conformation. Such sequence-dependent DNA structures, if present locally in regions such as operator sequences, could facilitate sequence-specific interactions. The crystal study also suggests possible geometrical parameters for the replication fork.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360210304
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  • 3
    Electronic Resource
    Electronic Resource
    The heat of dehydration of alumina trihydrate (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    Fire and Materials 2 (1978), S. 37-38 
    Details
    ISSN: 0308-0501
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Architecture, Civil Engineering, Surveying , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/fam.810020110
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  • 4
    Electronic Resource
    Electronic Resource
    Raman and IR spectra of matrix isolated OsO3F2 AND OsO4: The molecular shape of monomeric OsO3F2 (1976)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 4 (1976), S. 313-322 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: This paper reports fundamental vibration frequencies for molecular OsO3F2 and OsO4 isolated in argon matrices at low temperatures. OsO3F2 is shown to have D3h symmetry on the basis of Raman and IR selection rules, and this conclusion is confirmed by the results of 18O enrichment studies which demonstrate the presence of an OsO3 unit containing three equivalent oxygens. The argon matrix frequencies are 946.5 (A′1), 928.5 (E′), 646 (A′2), 619 (A′/1) 348 (E″), 316.5 (E′) 258 (A″2) and 206 (E′) cm-1. High resolution spectra are also reported for matrix isolated Os16O4 (ν1 963, ν2 332, ν3 956, and ν4 327 cm-1) and for 18O enriched OsO4 species.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250040313
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