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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 58 (1980), S. 395-402 
    ISSN: 1432-1440
    Keywords: Obstructive airway disease ; Localisation of the receptors ; Fenoterol ; Localisation of the effect of β-receptor-stimulation ; Ascaris suum-anti-gen ; Atemwegsobstruktion ; Receptorenlokalisation ; Fenoterol ; Wirkort der β2-Receptorenstimulatoren ; Ascaris suum-Antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei gegen Ascaris suum-Extrakt überempfindlichen Hunden kann eine Atemwegsobstruktion sowohl vom oberen als auch vom unteren Teil des Atemtraktes her ausgelöst werden. Fenoterol als β2-Receptorenstimulator vermindert diese Reaktion durch Aerosol-Applikation sowohl an dem oberen als auch an dem unteren Teil des Atemtraktes. Der durch Belegung des oberen Teils des Atemtraktes erzielte Effekt ist viel stärker und länger anhaltend als derjenige, der von den unteren Abschnitten oder bei intravenöser Gabe zu erzielen ist. Ein direkter Effekt des β2-Receptorenstimulators am sensorischen Teil des Reflexweges der Reflexbronchokonstriktion ist anzunehmen. Auch sprechen die Ergebnisse dafür, daß nach Fenoterolbelegung der oberen Atemwege auch die im unteren Atemtrakt auslösbaren Bronchokonstriktionen zu beeinflussen sind. Dieser Effekt muß nicht resorptiv-systemisch sein. Für die Klinik ist weiter zu prüfen, welche Rolle in der Pathogenese wie in der Behandlungsfähigkeit die verschiedenen Bereiche des Respirationstraktes für individuelle Formen der Atemwegsobstruktion spielen.
    Notes: Summary On dogs sensitive against Ascaris suum extract an increase of the airway resistance can be caused by challenge alone on the upper part or the lower part of the airways by Ascaris suum extract. Fenoterol as β2-receptor stimulator is capable to decrease this reaction by deposition of this drug on the upper part as on the lower part of the airways. The effect of Fenoterol on the upper part of the airways is much stronger and lasts much longer than on the lower part of the airways or by intravenous route. A direct effect of the β2-receptor stimulator Fenoterol on the sensoric part of the reflex way of the reflex bronchoconstriction must be considered. It will be also discussed that the local application of Fenoterol on the upper part of the airways may influence also the reaction of the bronchial muscles in the lower part of the airways without a direct resorptive-systemic effect. The relationship of these findings for the clinical situation on man has to be investigated.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 59 (1981), S. 391-395 
    ISSN: 1432-1440
    Keywords: Obstructive airway disease ; Clinical course ; Functional results ; Outcome of the patients ; Obstruktive Atemwegserkrankung ; klinischer Verlauf ; Funktionsstörungen der Behandlungsergebnisse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 80 Patienten mit chronischer obstruktiver Atemwegserkrankung wurden nach dem ersten klinischen Eindruck in 3 Gruppen unterteilt: relative gut, schlecht und sehr schlecht. Es wurden zwischen den 3 Gruppen z.T. signifikante Unterschiede in den täglichen Sputummengen, der Purulenz des Sputums und der Häufigkeit von Zyanose wie der Häufigkeit peripherer Oedeme gefunden. In Gruppe III waren der arterielle Sauerstoffdruck am niedrigsten und der arterielle Kohlensäuredruck am höchsten. Die Strömungswiderstände in den Atemwegen waren in den schlechteren Gruppen nur mäßig höher. Die Patienten der schlechtesten Gruppe waren aber älter und deren Krankheit dauerte ebenfalls signifikant länger. Der klinische Eindruck stimmt nicht immer mit dem Ausmaß der Veränderungen eines einzelnen Funktionstests überein. Zur Festlegung einer adäquaten Therapie ist das Wissen um alle verfügbaren Parameter die beste Voraussetzung.
    Notes: Summary A clinical, functional and therapeutic study was carried out in 80 patients with chronic obstructive airways disease. According to the clinical observation on admission they were divided in three different groups: mild, moderate and severe. There were some differences in the amount of sputum, purulence of the sputum, cyanosis and peripheral oedema between the three groups. Group III have had a lower PO2a and higher PCO2a. Airways resistance was nearly the same in all groups. However, the patients of the worse groups (II+III) were significantly older and their disease was of longer duration. “Clinical impressions” do not always agree with single functional tests. To plan a good therapeutic regime all the available data should be considered.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 182 (1983), S. 153-166 
    ISSN: 1433-8580
    Keywords: Tracheal lavage ; Allergen ; Acetylcholine, histamine ; Hyperreactivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of tracheal lavage with an allergen on the airway response to bronchial challenge with histamine, acetylcholine, and ascaris extract was investigated in 36 dogs. High histamine concentrations were measured in the tracheal solution after lavage with allergen. This amine, released on the mucosal surface, was observed in only very small concentrations in the circulation. Airway response to acetylcholine inhalation was significantly increased after tracheal lavage with allergen. This hyperreactivity of the lower airways induced by tracheal lavage with an allergen suggests that a reflex mechanism is involved. After histamine inhalation a significantly larger antigen-induced histamine release to tracheal lumen was observed. No influence on airway response was found after tracheal lavage with H2O.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1750
    Keywords: Allergen ; Disodium Cromoglycate ; Airway Resistance ; Acetylcholine ; Histamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Respiratory hypersensitivity to ascaris extract aerosol and the potentation of airway resistance increase caused by acetylcholine and histamine challenge produced by this allergen exposition were carried out on four dogs. The effect of disodium cromoglycate on these reactions was also studied. All animals presented significant respiratory distress with ascaris extract aerosol, which could be avoided by previous exposure to disodium cromoglycate aerosol. The increased response of the bronchial system to acetylcholine and histamine, observed after allergen aerosol, could not be abolished by disodium cromoglycate aerosol.
    Type of Medium: Electronic Resource
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