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  • 1980-1984  (2)
  • 1975-1979
  • Alternating current stimulation  (1)
  • Body weight loss  (1)
  • Meperidine  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Acute physical dependence induced by continuous intravenous infusion of morphine or meperidine in the rat (1981)
    Springer
    Psychopharmacology 73 (1981), S. 215-218 
    Details
    ISSN: 1432-2072
    Keywords: Intravenous infusion ; Body weight loss ; Morphine ; Meperidine ; Physical dependence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An intravenous infusion method is described for rapidly producing physical dependence in rats. Rats were infused with morphine or meperidine for 24 or 48 h at constant rates and the development of physical dependence was assessed by body weight loss after naloxone challenge. Naloxone challenge induced body weight losses that were dependent upon magnitude, rate and duration of infusion. The steady-state concentrations of morphine (4 mg/kg/h) in serum and meperidine (6 mg/kg/h) in plasma were 4 and 2.5 μg/ml, respectively. Morphine concentration in the brain in the steady-state (4 mg/kg/h) was 0.7 μg/g and in the serum was proportional to the infusion rate. Maximum body weight loss was significantly correlated with total amount of infused morphine, but not with the steady-state concentration of the drug in the serum. These results suggest that total doses of infused morphine, not steady-state concentrations, are critical in producing body weight loss.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422405
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Response of the visual system evoked by an alternating current (1983)
    Springer
    Medical & biological engineering & computing 21 (1983), S. 47-50 
    Details
    ISSN: 1741-0444
    Keywords: Alternating current stimulation ; Diagnosis of eye diseases ; Electrically evoked response (e.e.r.) ; Electroretinogram (e.r.g.) ; Optimum stimulus frequency ; Pigmentary retinal dystrophy (retinal disease) ; Retinal dystrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Alternating current stimulation of the eye generates an occipital electrically evoked response (a.c.-e.e.r.) of which the frequency characteristic shows a monophasic pattern for which the optimum stimulus frequency for evoking a maximum response is 18 Hz. A.C.-E.E.R. is a very useful tool for making a diagnosis of pigmentary retinal dystrophy and is different from the e.r.g. in that it is not affected by diseases of the optical system such as strong refractive anomalies or vitreous opacities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02446405
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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