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  • 1980-1984  (4)
  • 1975-1979  (1)
  • Substance P  (5)
  • 1
    Electronic Resource
    Electronic Resource
    Release of histamine by neuropeptides from the perfused rat hindquarter (1983)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 322 (1983), S. 153-157 
    Details
    ISSN: 1432-1912
    Keywords: Histamine release ; Mast cells ; Substance P ; Substance P analogues ; VIP ; Somatostain ; Capsaicin ; Plasma extravasation ; Rat hindquarter preparation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The release of histamine and serotonin by neuropeptides and capsaicin was measured in the isolated perfused rat hindquarter preparation. 2. Substance P and two antagonistic peptides, [d-Pro2, d-Phe7, d-Trp9]-SP and [d-Pro2, d-Trp7,9]-SP, released histamine, the SP(4-11) and SP(6-11) analogues did not. VIP and somatostatin released histamine and also serotonin. No amines were released by bombesin. Thus, all amine releasing peptides possessed at least two basic charges. However, the histamine releasing activity of the neuropeptides tested did not correlate with their reported ability to cause vasodilatation and plasma extravasation. 3. The SP(4-11) and SP(6-11) analogues which did not release histamine caused plasma extravasation. It is concluded that SP causes plasma extravasation by a direct action on blood vessels. 4. Capsaicin released only serotonin but no histamine either in untreated rats and such densensitized with capsaicin as neonates. 5. In rats desensitized with capsaicin 4 days prior to the experiment the substance P induced histamine release was as high as in untreated controls; it was, however, absent in rats desensitized with capsaicin as neonates. It is assumed that the sensitivity of mast cells to substance P is lost after degeneration of substance P containing primary sensory fibers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00512389
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  • 2
    Electronic Resource
    Electronic Resource
    Substance P immunoreactivity in the rat mammary nipple and the effects of capsaicin treatment on lactation (1984)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 328 (1984), S. 1-8 
    Details
    ISSN: 1432-1912
    Keywords: Substance P ; Capsaicin ; Mammary nipple ; Lactation ; Suckling reflex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Tissue concentrations of substance P immunoreactivity (SP-I) were measured in rat mammary nipples and were significantly greater than in ventral abdominal skin in nonpregnant and pregnant rats. In contrast, the concentration of nipple SP-I was lower than that of skin in twelve day lactating animals. 2. The mean total SP-I content of the pooled twelve nipples from each rat was not significantly different in nonpregnant, pregnant or lactating rats. However, the mean weight of the pooled twelve nipples from each rat was significantly higher in the lactating rats than in pregnant rats. 3. Immunohistochemistry revealed SP-I nerve trunks and single fibers throughout the nipples of lactating rats. Nerve fibers were observed among smooth muscle and along blood vessels throughout the dermis and in association with epidermal structures. Some SP-I fibers were also observed in association with the main lactiferous duct and mammary gland secretory parenchyma. 4. Radioimmunoassay and immunohistochemistry of nipples from lacting rats treated with capsaicin as neonates revealed a marked depletion of SP-I. 5. Rats treated with capsaicin as neonates had a normal gestation period and produced litters of normal size and birth weight. However, the litters of these lactating rats grew at a significantly slower rate than litters from controls. 6. The quantity of milk obtained from capsaicintreated lactating dams, following a one hour suckling period on the twelfth day of lactation, was significantly less than that obtained by litters of control dams. 7. It is concluded that capsaicin-sensitive primary sensory nerves of the mammary nipple play a role in the afferent limb of the suckling reflex. One transmitter candidate for these nerves is substance P.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496096
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  • 3
    Electronic Resource
    Electronic Resource
    Substance P: Characteristics of binding to synaptic vesicles of rat brain (1979)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 306 (1979), S. 45-51 
    Details
    ISSN: 1432-1912
    Keywords: Substance P ; Substance P analogues ; Enkephalin ; Synaptic vesicles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The binding of substance P (SP) to synaptic vesicles from rat brain was studied by use of the 125I-Tyr8-analogue of SP. 2. The pH dependence of the binding of both peptides to the lipid extractable fraction of synaptic vesicles was shown to be comparable. 3. The binding of 125I-Tyr8-SP shows a rate constant of association (k 1=6.6×106 M−1 s−1), a rate constant of dissociation (k −1=6.4×10−4 s−1) and gives a K Dof 1×10−10 M. K Dderived from equilibrium studies was 3.2×10−10 M. 4. The binding of 125I-Tyr8-SP to lipids of synaptic vesicles was shown to be reversible, saturable and highly specific. 5. The kinetic data suggest one population of binding sites with a maximal number of 0.8 pmol per mg protein of the synaptic vesicle preparation. 6. Unlabeled SP and the (2–11)-, (3–11)- and (4–11)-analogues of SP inhibit the binding of 125I-Tyr8-SP in a decreasing order in a competitive way when added in excess. Tyr8-SP and eledoisin did not interfere with the binding of 125I-Tyr8-SP whereas uperolein and neurotensin caused a partial inhibition. Physalaemin and d-Ala2-d-Met5-enkephalin enhance the binding of 125I-Tyr8-SP in a cooperative way.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00515592
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  • 4
    Electronic Resource
    Electronic Resource
    Release of histamine by substance P (1981)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 317 (1981), S. 67-70 
    Details
    ISSN: 1432-1912
    Keywords: Substance P ; Histamine ; 5-Hydroxytryptamine ; Mast cells ; Rat hindquarter perfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The basic peptide substance P causes histamine release from peritoneal mast cells of the rat in vitro whereas the closely related neutral peptides eledoisin and physalaemin do not. 2. Infusion of substance P (7.4 nmol min−1), but not of eledoisin (8.4 nmol min−1) or physalaemin (7.9 nmol min−1), into the rat hindquater preparation caused a more than 4-fold increase of the histamine content in the venous outflow. The outflow of 5-HT remained unchanged under infusion of all three peptides. 3. No histamine depletion in the skin of the rat hind paw was observed following antidromic stimulation of the saphenous nerve or cutaneous application of mustard oil. Infusion of substance P (7.4 nmol min−1) caused a 47% depletion of histamine in the paw skin although only a small proportion of the infused substance P seemed to enter the tissue from the blood vessels. 4. The results further substantiate the view that substance P upon release from peripheral nerve endings induces release of histamine from cutaneous mast cells, a mechanism which contributes to neurogenic vasodilatation and plasma extravasation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00506259
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  • 5
    Electronic Resource
    Electronic Resource
    Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man (1984)
    Springer
    Cell & tissue research 235 (1984), S. 251-261 
    Details
    ISSN: 1432-0878
    Keywords: Substance P ; Respiratory tract ; Vagal nerves ; Capsaicin ; Mammals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The occurrence and origin of substance P (SP)-immunoreactive (IR) nerves in the lower respiratory tract was studied by means of immunohistochemistry in the guinea-pig, rat, cat and man. In addition, biopsies from human material were also analysed by radioimmunoassay. SP-IR nerves were seen in four principal locations: 1) under or within the lining epithelium, 2) around blood vessels, 3) within the bronchial smooth muscle layer, and 4) around local tracheobronchial ganglion cells. Ligation experiments combined with capsaicin pretreatments indicated that all SP-IR nerves in the respiratory tract are sensory. The trachea seems to be mainly supplied by the vagal nerves, while intrapulmonary bronchi and blood vessels receive SP-IR nerves of both vagal and non-vagal (spinal) origin. SP-IR nerves were also found in the human bronchi with principally similar location as in the guinea-pig. The levels of SP-IR in the trachea and peripheral bronchi of man were about 3–4 pmol/g, which is in the same range as the content of corresponding tissues from the guinea-pig. In conclusion, the present experimental findings of SP-IR nerves in the lower respiratory tract in both experimental animals and man support the functional evidence for the importance of SP in the vagal and non-vagal (spinal) control of bronchial smooth muscle tone and vascular permeability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217848
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    Paper (German National Licenses)
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