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  • 1
    Electronic Resource
    Electronic Resource
    Release of histamine by substance P (1981)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 317 (1981), S. 67-70 
    Details
    ISSN: 1432-1912
    Keywords: Substance P ; Histamine ; 5-Hydroxytryptamine ; Mast cells ; Rat hindquarter perfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The basic peptide substance P causes histamine release from peritoneal mast cells of the rat in vitro whereas the closely related neutral peptides eledoisin and physalaemin do not. 2. Infusion of substance P (7.4 nmol min−1), but not of eledoisin (8.4 nmol min−1) or physalaemin (7.9 nmol min−1), into the rat hindquater preparation caused a more than 4-fold increase of the histamine content in the venous outflow. The outflow of 5-HT remained unchanged under infusion of all three peptides. 3. No histamine depletion in the skin of the rat hind paw was observed following antidromic stimulation of the saphenous nerve or cutaneous application of mustard oil. Infusion of substance P (7.4 nmol min−1) caused a 47% depletion of histamine in the paw skin although only a small proportion of the infused substance P seemed to enter the tissue from the blood vessels. 4. The results further substantiate the view that substance P upon release from peripheral nerve endings induces release of histamine from cutaneous mast cells, a mechanism which contributes to neurogenic vasodilatation and plasma extravasation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00506259
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  • 2
    Electronic Resource
    Electronic Resource
    Histamine release and mast cell alteration in the cat submandibular gland (1980)
    Springer
    Inflammation research 10 (1980), S. 173-174 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Histamine release from cat submandibular gland was studied in vitro under several conditions. Cholinergic drugs and compound 48/80 were effective in the following ranking: acetylcholine 〈 pilocarpine 〈 compound 48/80. These results are in agreement with our previous experiments in the intact animal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02024206
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  • 3
    Electronic Resource
    Electronic Resource
    Histamine and calcium secretion in the submandibular gland of the cat evoked by two types of stimulation (1987)
    Springer
    Inflammation research 20 (1987), S. 188-190 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this work was to compare the pools of histamine and calcium in the submandibular gland of the cat during two kinds of stimulation of the gland. Submandibular glands of the cat were stimulated electrically (chorda tympani nerve) and by close arterial infusion of pilocarpine. Each stimulation was adjusted in such a way as to obtain a near maximal secretory response. Concentrations of histamine and calcium were measured in nonstimulated and stimulated glands, in saliva, secreted during stimulation and in the venous outflow from the gland before and during the stimulation. The experiments showed that: 1. pilocarpine stimulation lowered the histamine concentration in the gland more than electrical stimulation of the chorda tympani nerve. Calcium stores in the gland were depleted to the same extent by each type of stimulation, 2. the concentration of histamine and calcium in the saliva produced by close arterial pilocarpine infusion was significantly higher than in the saliva secreted during nerve stimulation, 3. histamine and calcium concentrations were higher in the venous outflow from stimulated glands than before stimulation. The results indicate a close relationship between histamine and calcium in salivary secretion, although the origins of the two substances are different.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02074665
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  • 4
    Electronic Resource
    Electronic Resource
    Alterations in histamine levels in the rat induced by compound 48/80 (1987)
    Springer
    Inflammation research 20 (1987), S. 194-197 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Histamine release in the rat was inducedin vivo either by a single dose of compound 48/80 injected i.v. or by four repeated, daily doses of the same compound injected i.p. After i.v. injection the levels of blood histamine were determined and after i.p. injections the changes in both tele-methylhistamine and histamine levels in different tissues were investigated. I.v. injection of 48/80 induced a very rapid and marked increase of blood histamine by 7.4 to 11-fold over the control levels within the first two minutes. After repeated i.p. injections of compound 48/80 most tissues showed higher than normal tele-methylhistamine/histamine ratios. The results suggest that agents known to induce release of histamine from mast cells may exert significant changes in blood and tissue histamine levels and that liberated histamine is thereafter extensively catabolized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02074667
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of different calcium antagonists on histamine-and carbachol-induced acid secretion in the isolated mouse stomach (1989)
    Springer
    Inflammation research 27 (1989), S. 163-165 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Earlier experiments suggested that the action of muscarinic agonists in gastric acid secretion might be partly mediated by endogenous histamine release. This possibility could be tested by use of various calcium antagonists provided that they show different activity on histamine- and carbachol-induced secretion. In the present work, three calcium antagonists, verapamil, nifedipine, and sodium nitroprusside were used on the isolated mouse stomach where acid secretion induced by histamine and by carbachol was measured. Verapamil (100 μM) did not affect either histamine or carbachol-induced acid secretion. Nifedipine (100 μM) reduced histamine-induced acid secretion, whereas the effect of carbachol remained unchanged. Sodium nitroprusside (10–100 μM) reduced both histamine- and carbachol-induced acid secretion. The differences in action of calcium antagonists in histamine- and carbachol-induced acid secretion could exclude the possibility that the effect of carbachol is partly mediated by histamine release from mast cells present in the mouse stomach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02222228
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  • 6
    Electronic Resource
    Electronic Resource
    The role of mast cells in redistribution of tele-methylhistamine in the body (1991)
    Springer
    Inflammation research 33 (1991), S. 33-36 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The basis of this study was the assumption that mast cells can take up tele-methylhistamine (MeHi), as is known for other biogenic amines. The influence of extracellular MeHi on its uptake (active or passive) in isolated rat mast cells and in different rat tissues was studiedin vitro. Rat peritoneal mast cells were incubated for 15 or 30 min at 37 or 1°C with different concentrations of MeHi. Submandibular gland, skeletal muscle, lung and heart of the rat (200–500 mg of each) were chopped and incubated for 20 min at 37 or 1°C in buffer containing MeHi. Histamine (Hi) and MeHi in the cells and in the tissues were then determined by HPLC assay. Mast cells were capable of taking up MeHi in a time- and dose-dependent manner. MeHi levels increased from 5–10 ng per ml of incubated cell suspension (control) to 60–100 ng/ml after 15 min incubation. It can be assumed that the accumulation of MeHi in mast cells is due to a simple diffusion process since no significant change was noticed at 1°C. The preincubation of the cells with serotonin reduced MeHi accumulation, thus indicating MeHi competes with the same binding sites in mast cells as Hi and serotonin. Tissues showed high capacity for MeHi accumulation and MeHi surmounted endogenous Hi levels. Uptake was reduced at 1°C, yet the accumulation of MeHi was still high. The results indicate that mast cells can take up a smaller portion of free MeHi and they can have a function in its micro-regulation whereas other tissue cells have a predominant role in the removal of free MeHi from the blood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01993120
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  • 7
    Electronic Resource
    Electronic Resource
    Histamine tele-methylhistamine ratios in rat blood as a function of time after i.v. injection of compound 48/80 or histamine (1992)
    Springer
    Inflammation research 36 (1992), S. C394 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pharmacokinetic characteristics of histamine (Hi) and tele-methylhistamine (MeHi) were studied by following their concentrations in rat blood by HPLC after i.v. injection of Hi or compound 48/80. Both injected substances caused a significant elevation of Hi as well as MeHi levels in the blood. The elimination curves for Hi showed two phases and significant differences depending on the injected substance. Following Hi injection, blood MeHi reached a maximum within 10–30 min and returned to baseline after about 50 min. (Hi reached a maximum after 15 min.) Following injection of compound 48/80, Hi reached a maximum at 10–15 min and MeHi at 40–45 min. It can be suggested that the significance of Hi or MeHi data in the circulating blood depends on the time which elapses from the maximal Hi concentration in the blood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01997383
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  • 8
    Electronic Resource
    Electronic Resource
    Imipramine inhibits histamine and serotonin secretion induced by various secretagogues (1998)
    Springer
    Inflammation research 47 (1998), S. 28-29 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050252
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  • 9
    Electronic Resource
    Electronic Resource
    The role of tissue mast cells in exocrine secretion: Studies in the submandibular gland of the cat (1983)
    Springer
    Inflammation research 13 (1983), S. 188-193 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Histamine was found to be stored in the submandibular gland of the cat mainly in the mast cells. The amine is released from mast cells by compound 48/80 and pilocarpine. This was demonstrated in thein vivo andin vitro experiments and by histological examination. During the physiological stimulation of the gland, via the electrical stimulation of the chorda tympani nerve, significant changes of histamine content were not found. This could be explained by the increased synthesis of histamine during physiological stimulation. The physiological role of histamine in salivary secretion was demonstrated. The similarity between the roles of histamine, mast cells and chromaffine-like cells in salivary and gastric secretion is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967328
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  • 10
    Electronic Resource
    Electronic Resource
    Mast cells in the submandibular gland of cat (1983)
    Springer
    Inflammation research 13 (1983), S. 193-196 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of pilocarpine, compound 48/80 and the electrical stimulation of the chorda tympani nerve on the morphology of the mast cells from the submandibular gland of the cat were studied. All those different treatments of the gland caused the enlargement of the tissue mast cells. We observed also in the glands treated with pilocarpine and compound 48/80 a degranulation of mast cells. The degranulation was more expressed after the application of compound 48/80 to the animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967329
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