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  • 1
    Electronic Resource
    Electronic Resource
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 2 (1982), S. 0 
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Except for propranolol, no other b-blocker has been studied thoroughly in the prophylaxis of migraine. Of those studied, propranolol, atenolol and timolol were shown to be useful in double-blind clinical trials. The mode, or even the site of action of these drugs is unknown. Possible mechanisms of action are peripheral vascular effects, a central action, 5-HT antagonism, an anxiolytic effect and a multifactorial action. The only common property of the successful drugs is lack of partial agonist activity and their profiles do not fully support any of the above hypotheses. Trials of drugs in the prophylaxis of migraine have in general been unsatisfactory due to the difficulty in controlling many variables. b-blockers with differing properties offer an opportunity to define the properties necessary for anti-migraine activity and perhaps shed light on the pathogenesis of migraine.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing
    The @journal of analytical psychology 29 (1984), S. 0 
    ISSN: 1468-5922
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Psychology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Ground water 21 (1983), S. 0 
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: The hydraulic properties of commercial well screens were investigated to determine which screen design features affected head loss. The test program began with laboratory experiments and continued as a field-scale experiment with the installation of a well field in the Thames Valley Gravel Aquifer.The laboratory experiments indicated that, for all practical purposes, the head loss attributable to all of the screens tested was negligible. The experimental head loss, however, did vary from screen to screen, particularly at high intake velocities, and the screens could be ranked on the basis of their hydraulic efficiencies. This efficiency hierarchy is explained tentatively in terms of the screen construction methods and slot geometry. The field experiments showed that the hydraulic performance of all well screens is independent of screen design provided that the open area of the screen is above about 10%. The field experiments also indicated that the development capacity of a screen in a gravel aquifer is not wholly dependent on screen design, but that progressive development does increase the hydraulic efficiency of a well.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 297 (1982), S. 389-390 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] On the basis of measurements of carbon isotopes on rocks of various ages, early models assumed that the mean S13C (carbonate) values were constant3"6. In recent years, however, descriptions of secular variation of S13C values in carbonate rocks during the Mesozoic7'8 and Cenozoic9*10 have ...
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The electron gun incorporates a lanthanum hexaboride thermionic cathode, in the indirectly-heated rod configura tion9'10. For operation with a brightness 10 times greater than is normally obtained from a tungsten filament the cathode lifetime is regularly more than 100 h. Such brightness allows ...
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 259 (1976), S. 550-551 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A variety of modes of displacement have been put forward for the Great Glen Fault. Some are based on pre-Devonian evidence4'5 and are not considered relevant to our argument. We consider the following three: First, sinistral movements of 200-300 km (ref. 1) or - 500km (ref. 6). ...
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 270 (1977), S. 593-594 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Late Palaeozoic palaeomagnetic data are voluminous, largely because of the ubiquity of easily measured red beds and igneous rocks. Within these data there are systematic discrepancies and it has been suggested that the Permian geomagnetic field did not perfectly correspond to an axial dipole. ...
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Cancer chemotherapy and pharmacology 13 (1984), S. 91-94 
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The oral bioavailability of methotrexate is variable and may be dose-dependent. The absorption of ‘interval’ oral methotrexate, which is given between cycles of chemotherapy, is unknown. The bioavailability of oral methotrexate has been studied in eight patients, acting as their own controls, to assess the effect of subdivision of the dose, the formulation, and the timing of the methotrexate within the chemotherapy cycle. The mean bioavailability for all the oral methods of administration was 28.2%±3.7% compared with the same dose given IV. Absorption was uninfluenced by subdivision of the dose, liquid or tablet formulation, or administration on day 1 or day 10 of the chemotherapy cycle.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Cancer chemotherapy and pharmacology 12 (1984), S. 151-153 
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A range of clinical and industrial gloves have been evaluated to determine their ability to exclude penetration by cytotoxic drugs. Radiolabelled cyclophosphamide, methotrexate, daunomycin, cytosine arabinoside, and vincristine sulphate were studied in an equilibrium dialysis system in which the glove material was used as the dialysis membrane. The thicker gloves were the most effective, but very little drug crossed any of the gloves tested under laboratory conditions. Further studies to evaluate gloves in conditions of clinical use are now needed.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 262 (1976), S. 617-617 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Human skeletal muscle was obtained at surgery for total hip joint replacement. The preparation and incubation of the tissue (in Krebs-bicarbonate buffer with added bovine serum albumin Imgrnl-1 and glucose 16.67 x 10?3 M) was carried out using the method of Kirby, Leighton and Turner5. Muscle ...
    Type of Medium: Electronic Resource
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