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  • 1980-1984  (2)
  • 1975-1979  (5)
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  • 1
    Electronic Resource
    Electronic Resource
    Human hybridomas secreting anti-islet autoantibodies (1982)
    [s.l.] : Nature Publishing Group
    Nature 300 (1982), S. 264-267 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] After two unsuccessful fusions in which no anti-islet antibodies were detected, lymphocytes from 20 ml of blood from a patient with type I diabetes mellitus of 5 months' duration were fused using polyethylene glycol with the GM1500 6TG-2 myeloma-derived cell line (107 myeloma cells, ~2xl07 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/300264a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Linkage relationship between the genes for thymidine kinase and galactokinase in different primates (1976)
    Springer
    Somatic cell and molecular genetics 2 (1976), S. 21-26 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In this study we investigated the expression of primate galactokinase in somatic cell hybrids between a thymidine kinase-deficient mouse cell line and two different primate cell lines, one of which was derived from African green monkey kidney cells and the other from chimpanzee fibroblasts. All the African green monkey-mouse hybrid clones, selected in HAT medium, expressed monkey galactokinase activity and contained a monkey chromosome similar to a human E-group chromosome. When these clones were backselected in medium containing 5-bromodeoxyuridine, both this chromosome and the monkey galactokinase activity were lost. All the hybrid clones between mouse and chimpanzee cells, which were selected in HAT medium, contained the chimpanzee chromosome 17 and expressed chimpanzee galactokinase activity. These results indicate that the linkage relationship between galactokinase and thymidine kinase has been maintained in 3 divergent primate species—man, chimpanzee, and Old World monkey.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01539239
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Assignment of the gene for cytoplasmic glutamic-oxaloacetic transaminase to the region q24-qter of human chromosome 10 (1976)
    Springer
    Somatic cell and molecular genetics 2 (1976), S. 177-182 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Somatic cell hybrids between thymidine kinase-deficient mouse cells and human fibroblasts carrying a translocation of the distal third of the long arm of chromosome 10 to chromosome 17 were studied for the expression of cytoplasmic glutamic-oxaloacetic transaminase. A positive correlation between the expression of human cytoplasmic glutamic-oxaloacetic transaminase and the presence of the distal third of the long arm of chromosome 10 was established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01542630
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Assignment of the structural genes for the α subunit of hexosaminidase A, mannosephosphate isomerase, and pyruvate kinase to the region q22-qter of human chromosome 15 (1977)
    Springer
    Somatic cell and molecular genetics 3 (1977), S. 553-560 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Concordant segregation of the expression of the α subunit of human hexosaminidase A, human mannosephosphate isomerase, and pyruvate kinase was observed in somatic cell hybrids between either thymidine kinase-deficient mouse cells or thymidine kinase-deficient Chinese hamster cells and human white blood cells carrying a translocation of the distal half (q22-qter) of the long arm of chromosome 15 to chromosome 17. A positive correlation was established between the expression of these human phenotypes and the presence of the distal half of the long arm of human chromosome 15.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01539065
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Segregation of rat chromosomes in somatic cell hybrids between rat cells and HT 1080 human fibrosarcoma cells (1979)
    Springer
    Human genetics 〈Berlin〉 53 (1979), S. 17-21 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We produced somatic cell hybrids between HT 1080-6TG human fibrosarcoma cells and either rat white blood cells (WBC) or cells directly derived from rat spleen. Karyologic and isozyme analyses of hybrid cells indicated that they preferentially lose rat chromosomes. Hypoxanthine-aminopterine thymidine-selected hybrid clones expressing rat hypoxanthine phosphoribosyltransferase (HPRT), glucose-6-phosphate dehydrogenase (G6PD), and phosphoglycerate kinase (PGK) and containing the rat X chromosome were counterselected in a medium containing 30 μg/ml of 6-thioguanine. Concordant loss of the rat X chromosome and of the expression of rat HPRT and G6PD was observed in the hybrid clones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00289444
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Chromosomal proteins of mouse teratocarcinoma cells (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 113 (1982), S. 51-59 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: We have analyzed chromosomal proteins extracted from murine teratocarcinoma-derived stem cell lines (F9 and 12-1) and from their differentiated derivatives (12-1a) because of the differential sensitivity to DNase I digestion of these two cell types. The chromosomal DNA of stem cells is more sensitive to DNase I digestion than that of differentiated cells. Stem cell core histones are more highly acetylated than their differentiated counterparts, and certain high-mobility group (HMG) proteins from stem cells (HMG 1 and HMG 2) are found in greater amounts than in the differentiated cells though others (HMG 14 and HMG 17) occur in similar amounts. We have also identified a new HMG protein (HMG 9) that is present in stem cells and is lost following differentiation.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041130510
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Selective suppression of the transcription of ribosomal genes in mouse-human hybrid cells (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 98 (1979), S. 553-559 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Mouse-human hybrid cells that preferentially segregate either mouse or human chromosomes were analyzed for their relative content of mouse and human rRNA genes and for their capacity to transcribe these genes. A distinctive Hind III restriction fragment containing 28S rRNA sequences was used to distinguish between mouse and human rDNA and a set of distinctive loop structures in the 45S pre-rRNA was used to distinguish between mouse and human gene transcripts. Our results indicate that the genes of only one species are transcriptionally active in these hybrid cells, even though both sets of genes are present.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040980313
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    Paper (German National Licenses)
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