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  • 1980-1984  (2)
  • 1975-1979  (7)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    GENETIC STUDIES IN INBRED RATS. V. XENOANTISERA AGAINST TWO MAJOR HISTOCOMPATIBILITY ANTIGENS RAISED BY IMMUNIZATION WITH RED CELLS (1975)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 2 (1975), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Xenoantisera were raised in New Zealand white rabbits by immunizing with red blood cells from the S5B (Ag-B1) and ALB or BUF (Ag-B6) strains of inbred rats. By appropriate absorptions, specific Ag-B1, but not Ag-B6, reagent antiserum could be made. The anti-Ag-B antibodies required Ficoll as a diluent for haemagglutination, implying that they are IgG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1975.tb00522.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    GENETIC STUDIES IN INBRED RATS. IV. XENOANTISERA AGAINST RAT ERYTHROCYTE (Ag-C) ANTIGENS (1975)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 2 (1975), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Antibodies to the erythrocyte Ag-C antigens were raised by immunizing New Zealand white rabbits with rat red cells. Evidence that Ag-C antigens are not on lymphocytes includes: (1) Ag-C could not be detected on rat peripheral, splenic or thymic lymphocytes by lymphocytotoxicity using anti-Ag-C antisera, (2) xeno-antisera prepared against rat lymphocytes from which Ag-B antibodies were absorbed did not agglutinate rat red cells, and (3) absorption of reagent Ag-C antisera with lymphocytes did not remove the anti-Ag-C activity. Platelets also failed to absorb Ag-C antibodies from reagent anti-Ag-C antisera. The mixed lymphocyte reaction between strains within the same major histocompatibility (Ag-B) group but differing in Ag-C type showed no stimulation. This finding corroborates the studies which failed to demonstrate Ag-C on lymphocytes. Isoagglutinins for red cells were not detected in any of the strains of rats tested, but rabbit xenoagglutinins to rat and sheep red cells were found. Reagent Ag-C antisera were used to type some previously unreported strains of inbred rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1975.tb00521.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    GENETIC STUDIES IN INBRED RATS VII. TENTATIVE MODEL FOR THE MAJOR HISTOCOMPATIBILITY COMPLEX (1976)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 3 (1976), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Several lines of evidence are presented which support a tentative model of the major histocompatibility complex (MHC) of the rat. The serologically defined (SD), lymphocyte defined (LD) and immune response (Ir) loci are separate but linked, and there are probably two loci controlling the serologically defined antigens. The MHC in the rat appears to resemble that in the human more than that in the mouse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1976.tb00565.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    GENETIC STUDIES IN INBRED RATS. III. HISTOCOMPATIBILITY TYPE AND IMMUNE RESPONSE OF SOME MUTANT STOCKS (1975)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 2 (1975), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Eight mutant stocks of rats were typed for their histocompatibility (Ag-B) and red cell (Ag-C) antigens and were evaluated for their antibody responses to poly(Glu52Lys33Tyr15). The antibody responses were those predicted from the histocompatibility type, except for the B stock. These animals made a high antibody response, although their histocompatibility alleles were those normally associated with a low response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1975.tb00504.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Genetic and immunological characterization of naturally occurring recombinant B3 rats (1977)
    Springer
    Immunogenetics 5 (1977), S. 271-283 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The B-stock population of rats was bred for homozygosity at the loci controlling coat color. In this process, theAg-B1 andAg-B3 haplotypes became fixed in Hardy-Weinberg equilibrium. Extensive immunization and absorption studies showed that the specificities in the B-stock rats homozygous for theAg-B1 haplotype were the same as those found in the inbred F344 strain (Ag-B1), and that the specificities in the rats homozygous for theAg-B3 haplotype were the same as those found in the inbred BN (Ag-B3) strain. A homozygous line derived from the rats carrying theAg-B3 haplotype (B3) has the mixed lymphocyte reactivity and antibody responsiveness to poly (Glu52Lys33Tyr15) characteristic of the inbred strains in theAg-B4 group. Thus, it represents a naturally occurring recombination between the loci controlling MLR and immune responsiveness, on the one hand, and those controlling the Ag-B antigens on the other. Antibody responsiveness segregated with theAg-B3 haplotype in crosses between the B3 homozygotes and the low responder BUF and M520 strains; hence, this recombination is a stable one. There was no linkage of antibody formation or haplotype to coat color. The finding of a strain with a naturally occurring recombination in the major histocompatibility complex between the loci controlling mixed lymphocyte reactivity and the Ag-B histocompatibility antigens provides evidence for the separateness of these loci. Since the portion of the genetically determined mechanism controlling antibody responsiveness which is linked to the MHC was that characteristic of the MLR type, it too must lie outside the region defined by the serological specificities of theAg-B haplotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01570482
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Polymorphism of the major histocompatibility locus in the wild Norway rat (1976)
    Springer
    Immunogenetics 3 (1976), S. 193-200 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Specific alloantisera against the eight Ag-B groups found in inbred strains of rats were capable of reacting with all wild Norway rats (Rattus norvegicus) tested. Absorption studies, antisera production, and progeny testing involving wild rats showed that the antigenic specificities detected in the wild rat population were similar, if not identical, to the Ag-B antigens present in inbred strains. Xenoantisera prepared in rabbits against rat erythrocyte antigens (Ag-C1 and/or C2) reacted with erythrocytes from each wild rat tested. Progeny testing involving these erythrocyte antigens was identical to that observed in inbred strains. The restricted genetic polymorphism of theAg-B alleles in the wild rat population suggests that the functional and evolutionary significance of the major histocompatibility complex in the rat may not depend upon a high degree of genetic variability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01576951
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    CML characterization of a product of a second class I locus in the rat MHC (1982)
    Springer
    Immunogenetics 16 (1982), S. 143-155 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In the rat, genes that control the expression of target antigens detected by cell-mediated lympholysis (CML) are present in the major histocompatibility complex (MHC). The relationship of these loci, CT and Ag-L, to each other and to other loci within the MHC is unknown. In this report, we demonstrate the existence of a CML target antigen in the (DA × BN)F1 anti-DA.11(BI) strain combination. The gene coding for this antigen is linked to the RT1 complex as indicated by the CML reactivity of targets from backcross and congenic animals. Inhibition studies demonstrated that this antigen has the widespread tissue distribution characteristic of class I antigens, and the gene coding for this CML antigen maps coincident with the RT1.E class I locus as indicated by the lysis of targets from the recombinant strains r10 and r11. The CML can be blocked by antisera directed against a product of the RT1.E locus. The locus controlling this CML reactivity, like CT and Ag-L, has been separated from RT1.A by recombination; unlike CT and Ag-L, the product of this CML locus appears to be identical with an RT1.E allelic product that has been serologically identified and biochemically characterized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00364401
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Gene order in the major histocompatibility complex of the rat (1981)
    Springer
    Immunogenetics 13 (1981), S. 371-379 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The loci in the major histocompatibility complex (MHC) of the rat which code for class I and class II antigens—RT1.A and RT1.B, respectively — have previously been separated by laboratory-derived recombinants and by observations in inbred and wild rats. Closely linked to the MHC is the growth and reproduction complex (Grc) which contains genes influencing body size (dw-3) and fertility (ft). These phenotypic markers were used in this study to orient the A and B loci of the MHC. Two recombinants were used for mapping. The BIL(R1) animal is a recombinant between the MHC and Grc, and it carries the haplotype RT1.A lBlGrc+. The r10 animal is an intra-MHC recombinant, and it has the haplotype RT1.A nB1 Grc. These recombinants were characterized serologically, by mixed lymphocyte reactivity, by immune responsiveness to poly (Glu52Lys33Tyr15) and by the presence of the dw-3 gene. The data demonstrate that the gene order of the loci is: dw-3-RT1.B-RT1.A.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00346018
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    The genetic control of the antibody response in inbred rats (1975)
    Springer
    Molecular and cellular biochemistry 7 (1975), S. 145-156 
    Details
    ISSN: 1573-4919
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary The antibody response of genetically inbred rats to poly(Glu52Lys33Tyr15) is controlled by a complex polygenic system which includes at least two autosomal genes and a sex influence, which may also be genetically determined. The genetic control of the quantity, binding constants, and specificity of the antibody formed is linked to the major histocompatibility locus. Factors other than the major genetic ones and the sex influence also affect the quantity of antibody formed, since animals of the same genotype can make significantly different amounts of antibody, depending upon the crosses by which they acquire the major histocompatibility alleles. After immunization with poly(Glu52Lys33Tyr15) the low responders make fewer antibody-producing cells, are not capable of mounting a delayed hypersensitivity reaction to the polypeptide and appear to be deficient in their ability to produce the specific IgM antibody. Immunization of the low responders with antigen aggregated with methylated bovine serum albumin enhances the quantity of antibody formed, increases the binding constants and crossreactivity of the antibody and enhances the delayed hypersensitivity response. In contrast to the findings with the L-amino acid polypeptide, there does not appear to be any genetic control over the antibody response to the D-amino acid enantiomorph poly(dGlu52 dLys33 dTyr15), which is minimal in all strains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01731405
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    Paper (German National Licenses)
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