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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of medicinal chemistry 15 (1972), S. 1061-1065 
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 25 (1970), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 198 (1970), S. 33-45 
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Complete cerebral ischemia was produced in normothermic cats by clamping the innominate and subclavian arteries and simultaneous lowering of the systemic blood pressure. The effect of ischemia on the sensorimotor cortex was assessed by neurophysiological, electronmicroscopical, and biochemical observations. Nerve cell excitability, synaptic transmission and EEG activity recovered after ischemia of up to 1 hr. The neurophysiological recovery was paralleled by the restoration of the energy-producing metabolism which approached normal values when spontaneous EEG activity reappeared. Electronmicroscopy revealed the structural preservation of the cortex after the recovery of function.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 25 (1971), S. 197-206 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Concerning the question of the influence of cellular proliferation in the development of tumours, both a standard brain injury and also resorptive carcinogens with a neurotropic effect have been used in rats. The “model” of the transplacental carcinogenesis was employed. The resultant tumours corresponded, both in respect of their localization and in their morphology, almost exactly to the usual picture seen in this method of investigation but without employing trauma. The only unusual feature was the development of almost pure astrocytomata, with are otherwise very rare. Trauma evidently did not influence the location of the tumours.
    Notes: Zusammenfassung Zur Frage des Einflusses der Proliferationskinetik der Zellen auf das Tumorwachstum wurde an Ratten sowohl ein Hirntrauma gesetzt als auch resorptiv wirkende Carcinogene mit neurotropem Effekt appliziert. Es wurde das ‚Modell“ der diaplazentaren Karzinogenese angewandt. Die entstandenen Tumoren entsprachen sowohl ihrer Lokalisation als auch ihrer Morphologie nach genau dem gewohnten Bild bei dieser Versuchsanordnung ohne Trauma. Außergewöhnlich war lediglich das Auftreten fast reiner Astrozytome, die sonst sehr selten sind. Das Trauma beeinflußt die Lokalisation der Geschwülste nicht.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Un stress thermique aigu est un activateur rapide et puissant de la sécrétion du système rénineangiotensine et de l'aldosterone au cours d'une alimentation normo ou hyposodée, et peut être utilisé pour mesurer l'intégrité des systèmes de production de ces hormones.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 29 (1973), S. 144-145 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Zur Markierung des intrazellulären Ca im Fisch-Ei wurde45CaCl2-enthaltende Ringer-Lösung in die Abdominalhöhle vonOryzias latipes injiziert. 2–3 Tage nach der Injektion zeigt die Radioaktivität der abgelegten Eier ihr Maximum und nimmt dann allmählich ab. Aus Mikroautoradiogrammen der abgelegten Eier geht hervor, dass45Ca im Chorion und innerhalb des Eies eingebaut wird.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 30 (1974), S. 40-41 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Durch Epinephrine stimulierte menschliche Schweissdrüsen produzierten ein Sekret, welches 35–45 mÄq/l Natriumionen, 10–18 mÄq/l Kaliumionen und 15–19 mÄq/l Lactat enthielt. Adrenergisch stimulierter Schweiss hat demnach eine ähnliche Zusammensetzung wie cholinergisch stimulierter Schweiss. Mit dem Elektronenmikroskop liess sich nach der Stimulation durch Epinephrin eine deutliche Erweiterung der interzellulären Kanälchen zeigen. Diese und andere schon berichteten Beobachtungen sprechen dafür, dass Epinephrin die sezernierenden Zellen in einer ähnlichen Weise wie die cholinergischen Pharmaka direkt stimuliert.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-2013
    Keywords: Proximal Kidney Tubule ; Mercurials ; SH Reagents ; Site Group Reagents ; Transtubular Transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of site group reagents were tested on the following transport processes of the proximal convolution. Isotonic Na+ absorption, evaluated by the shrinking droplet procedure, histidine and glucose transport, evaluated by measuring the respective transtubular concentration difference at zero substance and water net flux. The test substances were applied either by continuous microperfusion of the peritubular capillaries or by luminal perfusion prior to the transport tests or by addition to the luminal test solution. The SH reagents (0.2 mM) N-ethylmaleimide,p-chloromercuribenzoate (pCMB) 3,6-bis-(acetatomercurimethyl)dioxane and Mersalyl (Salyrgane) caused 50% inhibition of the isotonic Na+ absorption in approximately 1.5 min when applied to the capillary perfusate. The same effect was reached in 2–3 min by 0.2 mMp-chloromercuriphenylsulfonate, benzamido-4-iodo-acetylstilbene-2,5-disulfonate and 2,2′-dihydroperoxy-2,2′-dibutylperoxide. However, the large molecular SH reagentspCMB-dextran T10 and benzoxanthene-3,4-dicarboxylic-N-iodoacetyloligoprolyl-2-aminoethylimid, did not inhibit the isotonic Na+ absorption. If an inhibitory effect was observed on the Na+ transport its onset was faster, when the substance was applied from the blood site than when it was given from the tubular lumen. Because SH reagents inhibit the isotonic Na transport faster when applied from the blood side, and because SH reagents with MW up to 690 are inhibitory whereas larger ones with MW over 1700 are not, it seems that they exert their inhibitory action on SH groups located a) predominantly on the blood side and b) deep within the membrane and not at the surface. Histidine- and glucose transport was inhibited only when the sodium transport was inhibited considerably. The oxygen consumption of teased kidney slices is not inhibited by 0.2 mMpCMB or Mersalyl within 10 min, but it is inhibited considerably by 1 mM of these substances in the same period of incubation time. The COOH reagents N,N′-carbonyl-diimidazole and N-ethyl-N′-(3-dimethyl-aminopropyl)carbodiimid (10 mM) and the NH2 reagents 4-acetamido-4′-isothiocyanatostilbene-2,2′-disulfonic acid, 2 Na+ (SITS) (1 mM) as well as danslychloride (applied from the lumen at 5 mM in paraffin oil) did not inhibit the isotonic Na+ absorption.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 200 (1971), S. 201-212 
    ISSN: 1432-1459
    Keywords: Concussion ; Experimental Transient Unconsciousness ; Traumatic Perivenous Edema
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ein neues Modell zur Erzeugung einer Hirnerschütterung im Tierexperiment, vergleichbar mit den Störungen beim menschlichen Trauma, wird beschrieben. Eine modifizierte Remington-Humane-„Kanone“ wurde benutzt, um einen Einzelschlag auf den Kopf eines Experimentaltieres zu richten, das in einer Weste hängend, Kopf nach oben, gehalten wurde. Von 39 Katzen starben 9 direkt nach dem experimentellen Trauma, 2 erlitten ein prolongiertes Koma. Bei den übrigen trat eine vorübergehende Bewußtlosigkeit von 10 sec bis 18 min ein, und sie überlebten, bis sie getötet wurden. Bei der histologischen Untersuchung fand sich bei einer reinen Hirnerschütterung kein perivenöses Ödem, sondern nur nach Hirnkontusion. Der Vergleichswert dieser Experimente mit den Vorgängen beim Menschen wird diskutiert.
    Notes: Summary A model method to produce, experimentally, concussion in the cat was described and was comparable to concussion in man. A modified Remington Humane Stunner was used to apply a single blow to the head of the animal, which was suspended in a head — up position by means of a specially designed vest hanging down from the ceiling. Out of 39 cats subjected to trauma, 9 died shortly after the experiment and 2 suffered from prolonged loss of consciousness. The remaining cats showed transient loss of consciousness with full recovery from 10 sec up to 18 min later and survived until they were sacrified. The morphological study with conventional techniques revealed that perivenous edema did not occur in pure concussion, although if contusion of the brain occurred, perivenous edema existed. The comparability to the pathogenesis of perivenous edema in man was discussed.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Colloid & polymer science 252 (1974), S. 189-189 
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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