ISSN:
1432-0428
Keywords:
Streptozotocin diabetes
;
glucagon stimulation
;
adenylate cyclase dose response relationship
;
stimulatory effect of guanosine triphosphate
;
guanyl nucleotide-depending regulatory protein
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In view of controversial findings regarding the mechanism for the increased intracellular hepatic cyclic 3′:5′ adenosine monophosphate levels in diabetic rats, we studied the dose-response relationship of the adenylate cyclase to glucagon stimulation in severely diabetic and in diabetic, insulin-treated rats. An enhanced response to glucagon and an additional augmenting effect of guanosine triphosphate on hormonal stimulation of the adenylate cyclase activity were found in diabetes which were reversible with insulin treatment. The results suggest a role of the regulatory guanyl nucleotide-binding protein in diabetes leading to an increased dose response relationship of the hepatic adenylate cyclase system to glucagon.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00282591
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