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  • 1980-1984  (2)
  • 1970-1974
  • 1-(2-tetrahydrofuryl)-5-fluorouracil  (1)
  • Deficiency of dihydrobiopterin  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Hyperphenylalaninemia due to impaired dihydrobiopterin biosynthesis (1981)
    Springer
    European journal of pediatrics 136 (1981), S. 275-280 
    Details
    ISSN: 1432-1076
    Keywords: Atypical PKU ; Deficiency of dihydrobiopterin ; Neurotransmitter treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A fourteen month-old boy with atypical phenylketonuria was treated with 5-hydroxytryptophan, L-dopa and peripheral aromatic amino acid decarboxylase inhibitor (Ro 4-4602:benserazide). Despite the good control of plasma phenylalanine on a low phenylalanine diet, he had shown no improvement in his development but progressive neurological symptoms, such asiirritability, convulsions and decrease voluntary movement. After beginning neurotransmitter therapy, his irritability disappeared promptly and the other symptoms diminished. He gradually reached his developmental milestones. At two and a half years of age, he had recovered sufficiently to be able to walk freely on treatment with 13 mg/kg/day of 5-hydroxytryptophan, 11 mg/kg/day of L-dopa and 2.7 mg/kg/day of benserazide in combination with slight restriction of phenylalanine intake (100 mg/kg/day). Levels of serotonin and 5-hydroxyindoleacetic acid were low in the patient's CSF. His urinary biopterin (Crithidia factor) excretion was low. An increase in serum biopterin following L-phenylalanine loading was not found. Dihydropteridine reductase activity in his skin fibroblasts was normal. He excreated large amounts of erythro- and threo-neopterins (but only a trace of biopterin) in his urine. After loading with phenylalanine the urinary excretion of neopterins was even more enhanced, but biopterin remained at low levels. These findings indicated that the patient has a dihydrobiopterin synthetase deficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442994
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Interaction of 5-trifluoromethyluracil with sodium poly-α,L-glutamate (1983)
    Springer
    Colloid & polymer science 261 (1983), S. 467-470 
    Details
    ISSN: 1435-1536
    Keywords: 5-trifluoromethyluracil ; Sodium poly-α,L-glutamate ; Interaction ; Viscosity ; 1-(2-tetrahydrofuryl)-5-fluorouracil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The purpose of our research is to obtain an understanding of the binding mechanism and to the correlations in term of chemical structure and the potentiactive drug activity. The interaction of 5-trifluoromethyluracil (although 5-trifluoromethyluracil do not used as anticancer drug, the structure of the compound has similar structure with 5-fluorouracil) with sodium poly-α,L-glutamate in aqueous solution was studied with a spectral method and viscosity measurement. From the binding data, the molar change in enthalpy, entropy and the number of binding sites on polymer were calculated. It is very interesting that the value ofδH
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01419829
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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