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Investigations on karyotype evolution in patients with chronic myeloid leukemia (CML) (1984)

Haas, O. A. ; Schwarzmeier, J. D. ; Nacheva, E. ; [et al.]

Springer

Annals of hematology 48 (1984), S. 33-43

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ISSN: 1432-0584

Keywords: Chronic myeloid leukemia ; Chronic and acute phase of CML ; Chromosomal findings ; Clinical course

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary In an attempt to relate karyotype evolution to clinical and hematological data serial chromosomal analyses were performed in 31 patients with chronic myeloid leukemia (CML), both in chronic and acute phases. Our results in Philadelphia chromosome (Ph1)-positive CML are in line with karyotype profiles described in the literature. In addition, we report on chromosomal findings in 4 cases of Ph1-negative disease, one presenting with an iso17q chromosome in the acute phase, an aberration otherwise typical for acute transformation in Ph1-positive CML. The same chromosomal abnormality was observed in a small population of Ph1-negative cells present in one of two patients with mixed Ph1-positive/Ph1-negative CML. The first case of a female patient with the loss of a sex chromosome in Ph1-positive cells is reported. Two patients with unusually long and mild chronic phases despite the presence of trisomy 8 in their karyotypes are described. Our findings suggest that the order of appearance of additional chromosomal changes of CML is of prognostic significance for the progression and the clinical picture of the disease.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00320715

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High temperature (GC)2 and (GC)2/CI-MS of nucleosides: Analysis of purinyl nucleoside isomer composition (1980)

Fischer, P. ; Lösch, G. R. ; Müller, D.

Weinheim : Wiley-Blackwell

Journal of High Resolution Chromatography 3 (1980), S. 161-165

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ISSN: 0935-6304

Keywords: GC, GC/MS ; Capillary, HMDS-deactivated ; On-column injection ; Nucleoside linkage isomers ; Separation, structural assignment feasibilities ; Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The analysis of low-volatile polar nucleosides by (GC)2/FID and (GC)2/CI-MS, employing HMDS-deactivated glass capillary columns and on-column injection, is described. The four linkage isomers of a specific nucleoside, formed in the synthetic procedure, are in each case sufficiently well separated in the chromatogram; GC/CI-MS allows for a differentiation of N-7 and N-9 linkage isomers.

Additional Material: 4 Ill.