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  • 1
    Electronic Resource
    Electronic Resource
    Mechanism of Halogen-Metal Interconversion between Aryl Bromides and Aryllithium Compounds. II. Rate Studies (1966)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 88 (1966), S. 969-974 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00957a020
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  • 2
    Electronic Resource
    Electronic Resource
    Mechanism of Halogen-Metal Interconversion between Aryl Bromides and Aryllithium Compounds. I. Equilibria (1966)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 88 (1966), S. 964-969 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00957a019
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Characterization of Catecholamine-Storage Organelles in Transplantable Phaeochromocytoma and Adrenal Glands of Rats (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 38 (1982), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The properties of the catecholamine-storing organelles from transplantable rat phaeochromocytoma and rat adrenal glands were compared by density gradient centrifugation. It was shown that tumour granules are more heterogeneous and less dense than adrenal granules. Both granule preparations can take up catecholamines and nucleotides by a process driven by an electrochemical proton gradient. Dopamine β-hydroxylase and glycoprotein III were analysed by immunological techniques. Glycoprotein III was shown to be a specific component of chromaffin granules. Tumour tissue (average weight 700 mg) contains amounts of these antigens comparable to those in 210 adrenals. The biosynthesis of granules in the tumour apparently occurs at a low rate, making turnover studies difficult. The transplantable rat phaeochromocytoma is very useful for studies on the uptake properties and the immunological characteristics of rat catecholamine storage granules because one tumour provides an amount of material that could otherwise be obtained only from a large number of adrenal glands.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1982.tb08675.x
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  • 4
    Electronic Resource
    Electronic Resource
    Uptake of Nucleotides and Catecholamines by Chromaffin Granules from Pig and Horse Adrenal Medulla (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 35 (1980), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The uptake of nucleotides and Catecholamines into chromaffin granules from adrenals of pigs and horses is similar to that previously seen in bovine chromaffin granules. The rate of [3H]ATP uptake at 2 mM-ATP concentration was 0.42 ± 0.06 and 0.15 ± 0.02 nmol/mg protein/min for pig and horse granules, respectively. The apparent Km's were 1.37 mM for pig granules, 0.89 mM for horse granules, and 1.2 mM for ox granules. The sensitivity of the uptake for nucleotides and catecholamine to specific inhibitors was found to be similar in granules from pig and ox, indicating that the same mechanisms of uptake are involved in both species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1980.tb12516.x
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  • 5
    Electronic Resource
    Electronic Resource
    Dopamine β-Hydroxylase and Other Glycoproteins from the Soluble Content and the Membranes of Adrenal Chromaffin Granules: Isolation and Carbohydrate Analysis (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 38 (1982), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Chromogranin A and two other proteins (A1 and A2) of the soluble proteins of bovine chromaffin granules were isolated by extraction from polyacrylamide gels after electrophoresis. The carbohydrate content of these proteins was 5%, with galactose, N-acetylgalactosamine, and sialic acid as the main sugars. Membranes of chromaffin granules were solubilized with sodium dodecyl sulphate (SDS) and three glycoproteins were isolated by sequential affinity chromatography on Concanavalin A (Con A) and wheat germ lectin (WGL) Sepharose columns. Two glycoproteins, designated GP II and III, were found to have a high carbohydrate content of about 30%. Mannose, galactose, N-acetylgalactosamine, and sialic acid were the main sugars. In addition membrane-bound dopamine β-hydroxylase was isolated by this procedure. No significant differences between the carbohydrate composition of the membrane-bound and the soluble enzyme were revealed. It was shown that all four subunits of dopamine β-hydroxylase possess carbohydrate chains with an affinity for Con A. The isolation methods established in this study will be useful for immunological studies on these glycoproteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1982.tb08691.x
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  • 6
    Electronic Resource
    Electronic Resource
    The Proteins of Catecholamine-storing Organelles (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 15 (1982), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1982.tb03759.x
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  • 7
    Electronic Resource
    Electronic Resource
    Isolation and Immunological Characterization of a Glycoprotein from Adrenal Chromaffin Granules (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 42 (1984), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: A glycoprotein (s-GP III) was isolated from the soluble lysate of chromaffin granules by chromatography with immunoaffinity and lectin columns. An identical protein (m-GP III) was shown to be present in the granule membranes. The apparent molecular weight of these glycoproteins as determined by the electrophoresis system of Laemmli (1970) was 43,000 under reducing conditions. In the absence of mercaptoethanol they aggregated to dimers. Antisera were raised against both the soluble and the membrane-bound forms of this glycoprotein. With these antisera GP III was further characterized: Immunoreplicas were obtained after two-dimensional electrophoresis of soluble and membrane-bound proteins of chromaffin granules. GP III was identified as a protein with a rather broad pI (4.6-5.3), indicating microhetero-geneity. As shown by subcellular fractionation, m-GP HI is specifically confined to chromaffin granules. GP III can therefore be used as a marker for the membranes of these organelles. The soluble form is secreted from adrenal medulla during stimulation with carbamylcholine chloride. An immunologically identical antigen was detected in adeno- and neurohypophysis. The physiological function of GP III is still unknown. It does not demonstrate any of the enzymatic activities so far known to occur in chromaffin granules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1984.tb12704.x
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  • 8
    Electronic Resource
    Electronic Resource
    Charakterisierung der Lipide in chromaffinen Granula (1966)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 255 (1966), S. 94-95 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544871
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  • 9
    Electronic Resource
    Electronic Resource
    Über Lipide, insbesondere Lysolecithin, in den chromaffinen Granula verschiedener Species (1967)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 256 (1967), S. 407-415 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Chromaffine Granula und Mitochondrien des Nebennierenmarks wurden durch Zellfraktionierung isoliert und ihre Lipide untersucht. 2. Chromaffine Granula und Mitochondrien von Rind, Pferd und Schwein enthalten als Lipid-Hauptkomponenten Phosphatide und Cholesterin, wobei Granula eine relativ höhere Konzentration von Cholesterin als Mitochondrien enthalten. 3. Als Phosphatidfraktionen konnten in den chromaffinen Granula und Mitochondrien von Rind, Pferd, Schwein und Ratte Lecithin, Lysolecithin, Colamin-Kephalin, Serin-Kephalin, Inositphosphatid und Sphingomyelin festgestellt und quantitativ bestimmt werden. Bemerkenswert war der hohe Gehalt chromaffiner Granula an Lysolecithin (7–17% der Gesamtphosphatide). 4. Die Phosphatidzusammensetzung von Rattengranula war nach intensiver Stimulierung der Adrenalinsekretion durch Insulingabe nicht verändert. 5. Die mögliche Bedeutung der hohen LL-Konzentrationen in chromaffinen Granula für den Sekretionsmechanismus der Katecholamine wird diskutiert.
    Notes: Summary 1. Chromaffin granules and mitochondria were obtained from adrenal medullae of ox, horse, pig and rat and their lipid composition was investigated. 2. The major components of the lipids of each particle were phospholipids and cholesterol. Chromaffin granules were relatively rich in cholesterol. 3. In both particles the following phospholipids were detected by thin-layer chromatography: lysolecithin, lecithin, phosphatidylethanolamine (partly plasmalogen), phosphatidylserine, phosphatidylinostiol and sphingomyelin. Quantitative analysis revealed that chromaffin granules from ox, horse, pig and rat contained a high concentration of lysolecithin (7–17% of total phospholipids). 4. When the adrenal glands of rats were maximally stimulated with insulin, the phospholipid composition of the chromaffin granules did not change. 5. The possible role of lysolecithin in the secretion of catecholamines is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00536799
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  • 10
    Electronic Resource
    Electronic Resource
    Vergleichende Untersuchungen synthetischer Polypeptide am Darm in situ (1965)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 250 (1965), S. 251-252 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00258587
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