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  • 1
    Electronic Resource
    Electronic Resource
    Gewinnung und Eigenschaften der Katecholamin-speichernden Granula eines Phäochromocytoms (1967)
    Springer
    Journal of molecular medicine 45 (1967), S. 1238-1241 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary 1. The subcellular localization of catecholamines in a human phaeochromocytoma was investigated. 78% of the catecholamines could be sedimented. 2. The hormone containing granules were separated from lysosomes and mitochondria and their biochemical composition was determined. The molar ratio catecholamine/ATP was found to be 5,56. 63,4% of the proteins were water soluble. Lysolecithin comprised 17% of total lipid phosphorus. 3. These results are in good agreement with findings on granules from normal adrenal medullae of various species. 4. On incubation at 37° C tumour granules released their catecholamines at a rate similar to that of normal granules. 5. Possible explanations for the high catecholamine secretion from phaeochromocytomas are discussed.
    Notes: Zusammenfassung 1. Die subcelluläre Lokalisation der Katecholamine in einem Phäochromocytom wurde untersucht. 78% der Katecholamine waren sedimentierbar. 2. Die Hormon-speichernden Granula wurden von Lysosomen und Mitochondrien weitgehend abgetrennt und ihre biochemische Zusammensetzung untersucht. Der molare Katecholamin/ATP-Quotient betrug 5,56, die Eiweißlöslichkeit in Wasser 63,4% und der Lysolecithinanteil an den Phospholipiden 17%. 3. Diese Ergebnisse stimmen gut mit Befunden an Granula normalen Nebennierenmarks verschiedener Species überein. 4. Bei Inkubation (37° C) gaben Tumorgranula ihre Katecholamine mit ähnlicher Geschwindigkeit ab wie normale Granula. 5. Die möglichen Ursachen für die gesteigerte Katecholaminabgabe aus Phäochromocytomen werden diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01746270
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  • 2
    Electronic Resource
    Electronic Resource
    Studies on the Proteins from Chromaffin Granules of Ox, Horse and Pig (1966)
    [s.l.] : Nature Publishing Group
    Nature 211 (1966), S. 982-983 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the present investigation we compared the solubility of the proteins in chromafnn granules from ox, horse and pig and the behaviour of the soluble fraction in starch-gel and polyacrylamide disc electrophoresis. This comparative investigation was thought to provide further evidence for the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/211982a0
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  • 3
    Electronic Resource
    Electronic Resource
    Charakterisierung der Lipide in chromaffinen Granula (1966)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 255 (1966), S. 94-95 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544871
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  • 4
    Electronic Resource
    Electronic Resource
    Über Lipide, insbesondere Lysolecithin, in den chromaffinen Granula verschiedener Species (1967)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 256 (1967), S. 407-415 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Chromaffine Granula und Mitochondrien des Nebennierenmarks wurden durch Zellfraktionierung isoliert und ihre Lipide untersucht. 2. Chromaffine Granula und Mitochondrien von Rind, Pferd und Schwein enthalten als Lipid-Hauptkomponenten Phosphatide und Cholesterin, wobei Granula eine relativ höhere Konzentration von Cholesterin als Mitochondrien enthalten. 3. Als Phosphatidfraktionen konnten in den chromaffinen Granula und Mitochondrien von Rind, Pferd, Schwein und Ratte Lecithin, Lysolecithin, Colamin-Kephalin, Serin-Kephalin, Inositphosphatid und Sphingomyelin festgestellt und quantitativ bestimmt werden. Bemerkenswert war der hohe Gehalt chromaffiner Granula an Lysolecithin (7–17% der Gesamtphosphatide). 4. Die Phosphatidzusammensetzung von Rattengranula war nach intensiver Stimulierung der Adrenalinsekretion durch Insulingabe nicht verändert. 5. Die mögliche Bedeutung der hohen LL-Konzentrationen in chromaffinen Granula für den Sekretionsmechanismus der Katecholamine wird diskutiert.
    Notes: Summary 1. Chromaffin granules and mitochondria were obtained from adrenal medullae of ox, horse, pig and rat and their lipid composition was investigated. 2. The major components of the lipids of each particle were phospholipids and cholesterol. Chromaffin granules were relatively rich in cholesterol. 3. In both particles the following phospholipids were detected by thin-layer chromatography: lysolecithin, lecithin, phosphatidylethanolamine (partly plasmalogen), phosphatidylserine, phosphatidylinostiol and sphingomyelin. Quantitative analysis revealed that chromaffin granules from ox, horse, pig and rat contained a high concentration of lysolecithin (7–17% of total phospholipids). 4. When the adrenal glands of rats were maximally stimulated with insulin, the phospholipid composition of the chromaffin granules did not change. 5. The possible role of lysolecithin in the secretion of catecholamines is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00536799
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  • 5
    Electronic Resource
    Electronic Resource
    Lysolecithin und Phospholipasen im chromaffinen Gewebe (1967)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 257 (1967), S. 77-78 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00537453
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  • 6
    Electronic Resource
    Electronic Resource
    Über die Beeinflußbarkeit der emotionellen Mehrdurchblutung im Unterarm durch einen Beta-Blocker (1966)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 253 (1966), S. 55-56 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00259259
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  • 7
    Electronic Resource
    Electronic Resource
    Studies on the renal action of ouabain in the rat (1974)
    Springer
    Pflügers Archiv 349 (1974), S. 91-107 
    Details
    ISSN: 1432-2013
    Keywords: Distal Potassium Transport ; Distal Sodium Transport ; Tubular Effects of Ouabain ; Luminal Potassium Transport ; Peritubular Potassium Transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recollection micropuncture experiments were carried out on superficial distal rat tubules before and after the infusion of ouabain (0.3 ml h−1 of a 1.37×10−2 M solution) into the renal artery. Fluid was analyzed for14C-inulin, sodium (Na) and potassium (K). Experiments were done in rats on a low-potassium diet as well as in rats on a normal potassium intake. Ouabain induced natriuresis and kaliuresis. These diuretic effects were not restricted to the site of injection since similar but weaker effects were observed in the contralateral kidney. The effects of ouabain upon distal tubular electrolyte transport consisted in depression of sodium transport and an elevation of potassium concentrations in distal tubular fluid. The distal potassium effect in initially non-diuretic animals is considered to be due to partial inhibition of active potassium uptake across the luminal cell membrane of distal tubule cells. In animals reabsorbing potassium from the tubule lumen ouabain induceds a fall in net potassium reabsorption whereas in animals secreting potassium along the distal tubule it augments net potassium transfer from the peritubular to the luminal fluid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00586621
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