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  • 1980-1984  (2)
  • 1960-1964
  • Bone metabolism  (1)
  • Huntington's disease  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Whole body and regional retention of99mTc-labeled pyrophosphate at 24 hours: Physiological basis of the method for assessing the metabolism of bone in disease (1983)
    Springer
    Calcified tissue international 35 (1983), S. 37-42 
    Details
    ISSN: 1432-0827
    Keywords: 99mTc-pyrophosphate ; Bone metabolism ; Osteoporosis ; Osteomalacia ; Hyperparathyroidism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The retention of99mTc-labeled pyrophosphate (PPi) at 24 h was measured in 235 patients, 119 of whom had a normal bone metabolism. The mean retention in the group of normal subjects is 52% of the injected dose. Reproducibility of the measurement in a given person is 5.5% coefficient of variation (CV). The value depends strongly on sex (higher in males) and age (higher with increasing age, especially in cortical bone). Retention increases slowly with the decrease in glomerular filtration rate (GFR) between 50 and 120 ml/min; it rises very rapidly with values below 50 ml/min. The slowing down of the GFR with age does not account for the increase in PPi retention with age. When expressed as a percentage of the expected value for sex and age, retention is frequently low in osteoporosis (P〈.001), more so when urinary hydroxyproline is low; it is normal or high in osteomalacia, and in some cases rises after vitamin D treatment is started; it is high in hyperparathyroidism (P〈.01). The PPi retention is correlated with bone calcium accretion rate, alkaline phosphatase level, and above all, the urinary hydroxyproline level. The lower the bone mineralization (Ca/hydroxyproline ratio in biopsy), the higher the retention value. We conclude that the PPi retention is an index of bone metabolism when GFR is higher than 50 ml/min. It allows for classification of metabolic bone diseases according to the bone turnover rate. It has the advantage over the usual biologic examinations in that it affords better observation of highly localized bone disorders and can be used in combination with a morphologic record, the bone scintigraphy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02405004
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Huntington's Disease — Imbalance of free amino acids in the cerebrospinal fluid of patients and offspring at-risk (1982)
    Springer
    European archives of psychiatry and clinical neuroscience 231 (1982), S. 131-140 
    Details
    ISSN: 1433-8491
    Keywords: Huntington's disease ; Amino acid imbalance ; CSF ; Offspring at-risk ; Tyrosine metabolism ; Homocarnosine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 12 Patienten mit manifester Huntingtonscher Krankheit (HD), 8 nicht erkrankten Nachkommen und 16 nicht choreatischen Kontrollpatienten wurden 27 verschiedene Aminosäuren im Liquor cerebrospinalis (nüchterner Lumballiquor) untersucht. Asparagin, Isoleucin, Leucin, Phenylalanin, Histidin, Arginin, α-Aminoadipinsäure und Homocarnosin waren signifikant (P〈0.001) erniedrigt bei Patienten gegenüber den Kontrollen. Diese Veränderungen waren bei 5 neurophysiologisch auffälligen Nachkommen teilweise ausgeprägter, was für eine frühzeitige metabolische Störung spricht. Tyrosin war als einzige Aminosäure erhöht. Die Veränderungen sprechen für eine Aminosäurenimbalanz bei Huntingtonscher Krankheit, deren Bedeutung besprochen wird.
    Notes: Summary A total of 27 different amino acids were determined in the fasting, morning lumbar CSF of 12 patients with Huntington's Disease (HD), 8 at-risk offspring and 16 non-choreic control patients. A significant (P〈0.001) decrease was observed for asparagine, isoleucine, leucine, phenylalanine, histidine, arginine, α-aminoadipic acid and homocarnosine in patients with HD compared to the non-choreic controls. Only tyrosine was increased in HD. These alterations were to an extent more pronounced in 5 neurophysiologically conspicuous offspring. The alterations suggest that amino acid imbalance is an early metabolic disturbance in HD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00343834
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    Paper (German National Licenses)
    Fulltext
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