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  • 1980-1984  (1)
  • 1960-1964  (2)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    DIAMINE OXIDASE IN THE BRAIN OF VERTEBRATES (1963)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 10 (1963), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1963.tb09481.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Benzodiazepine Antagonist Ro 15–1788: Binding Characteristics and Interaction with Drug-Induced Changes in Dopamine Turnover and Cerebellar cGMP Levels (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 37 (1982), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The recently discovered benzodiazepine antagonist Ro 15-1788 was characterized in binding studies, and its potency and selectivity were determined in vivo by interaction with drug-induced changes in dopamine turnover and cerebellar cGMP level. Ro 15-1788 reduced [3H]flunitrazepam binding in the brain in vivo with a potency similar to that of diazepam and effectively inhibited [3H]diazepam binding in vitro (IC50= 2.3 ± 0.6 nmol/liter). [3H]Ro 15-1788 bound to tissue fractions of rat cerebral cortex with an apparent dissociation constant (KD) of 1.0 ± 0.1 nmol/liter. The in vitro potency of various benzodiazepines in displacing [3H]Ro 15-1788 from its binding site was of the same rank order as found previously in [3H]diazepam binding. Autoradiograms of [3H]Ro 15-1788 binding in sections of rat cerebellum showed the same distribution of radioactivity as with [3H]flunitrazepam. The attenuating effect of diazepam on the chlorpromazine- or stress-induced elevation of homovanillic acid in rat brain was antagonized by Ro 15-1788. Among a series of compounds which either decreased or increased the rat cerebellar cGMP level, only the effect of benzodiazepine receptor ligands (diazepam, zopiclone, CL 218 872) was antagonized by Ro 15-1788. Thus, Ro 15-1788 is a selective benzodiazepine antagonist acting at the level of the benzodiazepine receptor in the central nervous system. Peripheral benzodiazepine binding sites in kidney and schistosomes were not affected by Ro 15-1788.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1982.tb12546.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A new inhibitor of decarboxylase of aromatic amino acids (1962)
    Springer
    Cellular and molecular life sciences 18 (1962), S. 411-412 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung N-(DL-Seryl)-N′-(2,3,4-trihydroxybenzyl)hydrazin (Ro 4-4602) bewriktin vitro starke Hemmung der Decarboxylase, die durch Pyridoxal-5′-phosphat nicht und durch Dialyse nur wenig vermindert werden kann. Nach i.p. Applikation der Substanz kommt es zu starker Verminderung der Decarboxylase-Aktivität und zu mässiger Herabsetzung von 5-Hydroxytryptamin und Noradrenalin in verschiedenen Organen. Monoaminoxydase des Gehirns wirdin vivo durch Ro 4-4602 nicht beeinflusst.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02151490
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    Paper (German National Licenses)
    Fulltext
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