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Treatment of Sub-cellular Particles prior to Assay of the Enzymatic Marker, Succinic Dehydrogenase (1962)

JOHNSON, M. K.

[s.l.] : Nature Publishing Group

Nature 196 (1962), S. 1210-1211

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] 100 per cent recovery of activity is necessary in meaningful distribution studies and is usually, though not necessarily, achieved most easily when each fraction sample is made to show the maximum activity of which it is capable with the chosen assay system. For fractions obtained from brain ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/1961210a0

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Repeated small doses of a neurotoxic organophosphate (1980)

Lotti, Marcello ; Johnson, M. K.

Springer

Archives of toxicology 45 (1980), S. 263-271

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ISSN: 1432-0738

Keywords: Organophosphate neuropathy ; Organophosphate ; Chronic dosing ; Neurotoxic esterase

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The effects of small repeated oral doses of mono-2-cresyl diphenyl phosphate (MOCP, 2.5 mg/kg/day) on hen brain and spinal cord neurotoxic esterase (NTE) were measured. The enzyme levels were depressed to about 40% and 55% of normal respectively and maintained at that level for 8 weeks. No clinical and only doubtful histological signs of neuropathy were detected. Neuropathy could be precipitated by depressing the level to 〈 20% either with a single high dose (50 mg/kg), or by an increase of the repeated dose level to 5 mg/kg/day. There was no correlation between inhibition of NTE in the nervous tissue and the “NTE-like” activity in lymphocytes. “NTE-like” activity in spleen was consistently inhibited but to a lesser extent than that in the brain or spinal cord. Brain AChE and BuChE were not affected.