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  • 1980-1984  (2)
  • 1920-1924
  • 13CO2-Gehalt der Atemluft  (1)
  • Autonomic polyneuropathy  (1)
  • 1
    ISSN: 1436-6215
    Keywords: 13C-Atemtest ; natürlicher Isotopengehalt von Nahrungsmitteln ; 13CO2-Gehalt der Atemluft ; parenterale Ernährung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary The long-term variation of the mean δ13C-value of breath-CO2 of Europeans (base value −26‰) was ±1‰ over a period of several months. However, the ingestion of products from corn, a C4-plant, caused remarkably higher shifts. In a fasted state and during rest a stability of the base value of ±0.3‰ could be attained for several hours. Longer fasting periods imply a shift of the CO2-δ-value due to the metabolism of body products. — By a change of the main energy source to corn products the δ13C-base line could be shifted to −18‰ within one day. After this shift even the metabolism of products from C3-plants could be investigated. The degradation curve and the integral degradation of fats were largely dependent on the method of application, and the base value largely interfered with the results. The period of maximum disintegration for a naturally and uniformly labelled fat was different from that of an artificially labelled trilinoleate. The results shall be used for the adjustment and the correction of the base line in13C-breath tests, especially with patients under parenteral nutrition.
    Notes: Zusammenfassung Der mittlere δ13C-Wert im CO2 der Atemluft von Europäern (Basiswert −26‰) zeigt eine Langzeitschwankung über mehrere Monate von ±1,0‰; der Verzehr von Produkten aus C4-Pflanzen (z. B. Mais) hat allerdings erheblich höhere Änderungen zur Folge. Im Nüchternzustand und in Ruhe wird während 6 h eine Stabilität des Basiswertes von ±0,3‰ erreicht; nach längeren Nüchternphasen kann aber der Abbau körpereigener Substanzen zu Verschiebungen führen. Durch Umstellung der Energieversorgung auf Maisprodukte ist es möglich, den Basiswert innerhalb eines Tages auf −18‰ zu heben; dann läßt sich auch der Abbau von Substanzen aus C3-Pflanzen verfolgen. Der Verlauf und die Rate des Abbaues von markierten Fetten sind stark von der Art der Applikation abhängig, und die Messung des Gesamtumsatzes wird durch den Untergrund stark beeinträchtigt. Der Zeitpunkt des maximalen Abbaues von uniform markiertem Fett (Sojaöl) unterschied sich von dem eines in der Carboxylgruppe markierten Trilinoleats. Die Resultate sind Grundlage zur Einstellung bzw. Korrektur von Basiswerten bei13C-Atemtests, besonders bei Patienten mit parenteraler Ernährung.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 62 (1984), S. 399-405 
    ISSN: 1432-1440
    Keywords: Electronmicroscopy ; Diabetes mellitus ; Autonomic polyneuropathy ; Gut
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Gastrointestinal motility disorders induced by diabetes mellitus are most commonly manifested in the colon, and are considered to be an expression of diabetic autonomic polyneuropathy. In this study, for the first time, the intrinsic nervous system of the bowel has been subjected to an ultrastructural and morphometric examination in rectal biopsy material obtained from diabetics with and without diabetic enteropathy. In patients with diabetic enteropathy, the nerves of the submucous plexus (Meissner's plexus) revealed significant swelling of the axons, as an expression of neural degeneration. Furthermore, in about a half of these patients, thickening of the basal membrane of Schwann's cells was also detected. Additional, although unspecific, changes found in the diabetics were a quantitative increase in the lysosomes, lipofuscin and glycogen in the Schwann cells. The ultrastructural findings represent evidence for the presence of an intrinsic autonomic polyneuropathy in diabetics with diabetic enteropathy. At the same time, they indicate that the diagnosis of diabetic enteropathy is no longer merely an “exclusion” diagnosis.
    Type of Medium: Electronic Resource
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