ISSN:
1432-0428
Keywords:
Affinity chromatography
;
cord blood
;
diabetes
;
diabetic pregnancy
;
glycosylated fetal haemoglobin
;
glycosylated fetal plasma proteins
;
glycosylated haemoglobins
;
glycosylated plasma proteins
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We have used a simple affinity chromatography method to measure total glycosylated haemoglobins and glycosylated plasma proteins in maternal and cord blood at 50 normal deliveries. The affinity method gives equal weighting to glycosylated haemoglobins including haemoglobin F in cord blood. The mean values for glycosylated haemoglobins in maternal blood (6.49±1.2%) were significantly higher than those in cord blood (3.85±1.0%; p〈0.001). The difference with glycosylated plasma proteins was less marked (maternal blood 5.61±0.9% and cord blood 4.75±0.6%; p〈0.001). A contributory factor to these differences was the decrease in glucose concentration from 4.53±0.99 mmol/l in maternal blood to 3.59±0.8 mmol/l in cord blood. The results obtained at the birth of six children to diabetic mothers showed the same trends although the mean values for glycosylated haemoglobins (maternal blood 9.27±2.3%, cord blood 4.21±0.9%), glycosylated plasma proteins (maternal blood 7.44±1.6%, cord blood 5.45±1.7%) and glucose (maternal blood 10.22±7.3 mmol/l, cord blood 5.18±3.4 mmol/l) were higher in all samples than for the deliveries to non-diabetic mothers.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00284454
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