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  • 1980-1984  (4)
  • 2-Chloroethyl-nitrosoureas  (1)
  • 30% Saline Solution  (1)
  • CGP 6809  (1)
  • Cancer prevention  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Reduction of carcinogenicity of N-nitrosomethylurea by indomethacin and failure of resuming effect of prostaglandin E2 (PGE2) against indomethacin (1984)
    Springer
    Journal of cancer research and clinical oncology 108 (1984), S. 239-242 
    Details
    ISSN: 1432-1335
    Keywords: Indomethacin ; Prostaglandin E2 ; N-nitrosomethylurea ; Rat large bowel cancer ; Cancer prevention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nonsteroid antiinflammatory drugs such as indomethacin may play an important role in preventing the development of chemically induced experimental carcinomas of various organs including the large bowel in rats and mice. This effect might correlate with an inhibition of prostaglandin (PG) synthesis by these drugs. Sprague-Dawley rats were given three intrarectal doses of 4 mg N-nitrosomethyl-urea (MNU) within week 1 to induce large-bowel carcinomas. The experimental groups of rats received a 0.001% aqueous solution of indomethacin ad libitum as drinking water for days 1–8 and/or a subcutaneous injection of 500 μg/kg body weight of PGE2 immediately before and 2 h after each MNU dose. They were then maintained on basal diet and plain tap water without further treatment. At autopsy at week 31, the tumor incidence and the mean number of tumors per rat were 90% and 1.7 in untreated rats, 67% and 0.8 in indomethacin-treated rats, and 79% and 1.2 in indomethacin+PGE2-treated rats, respectively. The data indicate that indomethacin reduced the number of large-bowel tumors, while pharmacologic doses of PGE2 failed to reestablish the anticarcinogenic activity of indomethacin. It was concluded that a tolerable therapeutic dose of indomethacin can reduce the carcinogenic activity of MNU in the large bowel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402475
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Antitumor activity of new nitrosoureas on Yoshida sarcoma ascites cells implanted into the colon wall of rats (1981)
    Springer
    Journal of cancer research and clinical oncology 101 (1981), S. 285-302 
    Details
    ISSN: 1432-1335
    Keywords: Yoshida sarcoma ; Descending colon ; 2-Chloroethyl-nitrosoureas ; Sprague-Dawley rats ; Yoshida-Sarkom ; Colon descendens ; 2-Chlorethyl-nitrosoharnstoffe ; Sprague-Dawley-Ratten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die chemotherapeutische Wirkung von 12 neu entwickelten Nitrosoharnstoffen wurde vergleichend an Yoshida-Sarkom-Asziteszellen experimentell untersucht, die in die Wand des Colon descendens von Sprague-Dawley-Ratten implantiert worden waren. Cyclophosphamid sowie die Nitrosoharnstoffe BCNU, MeCCNU und Chlorozotocin dienten als positive Kontrolle. Unter den untersuchten Nitrosoharnstoffen zeigten 1-(2-Hydroxyethyl)-3-(2-chlorethyl)-3-nitrosoharnstoff (Hydroxyethyl-CNU), Chlorozotocin, 1-(2-Chlorethyl)-1-nitroso-3-(4-morpholino)-harnstoff, 1-(2-Chlorethyl)-1-nitroso-3-(1-piperidino)-harnstoff, 4-[1-(2-Chlorethyl)-1-nitroso]-3-[4-(2,6-dimethylmorpholino)]-harnstoff und 1-(2-Chlorethyl)-1-nitroso-3-(3,4-methylendioxybenzyl)-harnstoff die stärkste Aktivität in diesem Tumormodell. Auf Grund der vorliegenden Ergebnisse ist Morpholino-CNU als die erfolgversprechendste Substanz unter den neu synthetisierten BCNU-Analogen anzusehen.
    Notes: Summary The chemotherapeutic activity of 12 newly synthesized nitrosoureas was compared in tests using Yoshida sarcoma ascites cells implanted into the wall of the descending colon in Sprague-Dawley rats. Cyclophosphamide and the nitrosoureas, BCNU, MeCCNU, and chlorozotocin served as positive controls. Among the nitrosoureas tested, 1-(2-hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea (hydroxyethyl-CNU), chlorozotocin, 1-(2-chloroethyl)-1-nitroso-3-(4-morpholino) urea, 1-(2-chloroethyl)-1-nitroso-3-(1-piperidino) urea, 4-[1-(2-chloroethyl)-1-nitroso]-3-[4-(2,6-dimethylmorpholino)] urea, and 1-(2-chloroethyl)-1-nitroso-3-(3,4-methylenedioxybenzyl) urea were found to be the most active compounds in this tumor model. Based on the present results, morpholino-CNU is considered the most promising compound among these newly synthesized BCNU analogues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410114
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Chemotherapeutic studies on N-nitrosoacetoxymethyl-methylamine-and 1,2-dimethylhydrazine-induced colonic tumors in rats: Monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A (1982)
    Springer
    Journal of cancer research and clinical oncology 104 (1982), S. 115-131 
    Details
    ISSN: 1432-1335
    Keywords: Autochthonous colonic tumors ; N-nitrosoacetoxymethyl-methylamine ; 1,2-Dimethylhydrazine ; 5-Fluorouracil ; Ftorafur ; CGP 6809 ; CGP 15'720A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Colonic tumors were induced in male Sprague-Dawley rats by ten applications of 2 mg/kg/week N-nitrosoacetoxymethyl-methylamine (AMMN) or by three applications of 100 mg/kg/month 1,2-dimethylhydrazine (1,2-DMH). Application of AMMN and 1,2-DMH induced selective colonic tumors in 97% and 29–42% of the initial animals, respectively. Colonic-tumor-bearing animals were subjected to monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A. No cures were achieved. The different therapies did not exert any clear influence on the survival time of animals, except for animals pretreated with AMMN and then subjected to ftorafur therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402060
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Influence of daily subcutaneous administration of 6-methylprednisolone and oral application of 30% saline solution on tumorigenesis induced in mouse stomach by single application of 7,12-dimethylbenz(a)anthracene (1982)
    Springer
    Journal of cancer research and clinical oncology 103 (1982), S. 207-209 
    Details
    ISSN: 1432-1335
    Keywords: DMBA ; Prednisolone ; 30% Saline Solution ; Ulcers and papilomas of the forestomach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Combined treatment with DMBA, 6-methylprednisolone, and 30% saline solution induced papillomas in the forestomach of mice after a median latent period of 25 days.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00409650
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    Paper (German National Licenses)
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