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The sensitive period for ototoxicity of kanamycin in mice: Morphological evidence (1983)

Chen, C.-S. ; Saunders, J. C.

Springer

European archives of oto-rhino-laryngology and head & neck 238 (1983), S. 217-223

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ISSN: 1434-4726

Keywords: Kanamycin ; Cochlea damage ; Audiogenic seizures ; Sensitive period for ototoxicity ; Mice

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The ototoxicity of kanamycin was investigated in mice treated with the drug either from 6 to 9, 10 to 13, or 15 to 18 days of age. The results showed extensive damage to the outer-hair-cell (OHC) receptors of the cochlea in the 10–13-day group; some less severe damage to the OHC was found in the 6–9-day group, and little damage was observed in the 15–18 day group. The present finding is consistent with the view that the mouse cochlea is most vulnerable to the ototoxic effect of kanamycin during the period of its rapid development, i.e., between 10 and 13 days of age.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00453932

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Lattice vibrations of crystalline titanium and tin tetrachlorides (1984)

Tse, W. S. ; Liang, N. T. ; Chen, C. C. ; [et al.]

Chichester [u.a.] : Wiley-Blackwell

Journal of Raman Spectroscopy 15 (1984), S. 51-54

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ISSN: 0377-0486

Keywords: Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Physics

Notes: The vibrational spectra of polycrystalline samples of titanium and tin tetrachlorides at 80 K have been investigated by Raman spectroscopic techniques. In the intramolecular region, isotopic and crystalline field splittings are observed, in substantial agreement with earlier work. In the lattice region, ten of the twelve Raman-active lattice modes are observed. A simple model is suggested and used to distinguish the low-frequency lattice translational from librational modes.

Additional Material: 3 Ill.