Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 1980-1984  (5)
  • Analytical Chemistry and Spectroscopy  (2)
  • insulin structure-function  (2)
  • Salt tolerance
  • 1
    Electronic Resource
    Electronic Resource
    Solute distribution in Suaeda maritima (1983)
    Springer
    Planta 157 (1983), S. 344-349 
    Details
    ISSN: 1432-2048
    Keywords: Glycinebetaine ; Ion, inorganic (distribution) ; Salt tolerance ; Shoot (solutes) ; Solute distribution ; Suaeda
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The distribution of sodium, potassium and glycinebetaine in shoot tissues of salt-treated Suaeda maritima was examined by semi-micro techniques after extraction into toluene-water. Much higher K/Na ratios were observed in the apical regions and in axillary buds than in more mature, fully vacuolated tissues. The younger tissues also contained very high levels of glycinebetaine. Electron-probe X-ray microanalysis of bulkfrozen and fractured preparations showed higher K/Na ratios and higher levels of sulphur and phosphorus in the cytoplasm of leaf primordial cells than in vacuoles of either young or old leaves, although the total counts were higher in the vacuolar samples. The results are discussed in relation to current models of subcellular solute compartmentation and salt tolerance in the Chenopodiaceae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00397406
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Mechanism of action of insulin and insulin analogues (1981)
    Springer
    Diabetologia 20 (1981), S. 94-101 
    Details
    ISSN: 1432-0428
    Keywords: Chemically modified insulins ; gluconeogenesis ; glucose turnover ; insulin structure-function ; proinsulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A [14C]-glucose tracer infusion method was used to compare the effects of insulin infusion on glucose metabolism with the effects of infusion of three semisynthetic modified insulins and of proinsulin. Insulin produced hypoglycaemia in the anaesthetised dog by decreasing hepatic glucose production and increasing peripheral glucose utilisation. Compensatory antihypoglycaemic mechanisms eventually modified these responses. A1 B29-Diacetyl insulin exerted an hypoglycaemic effect entirely by stimulation of peripheral glucose uptake. A1-B29 crosslinked insulins and proinsulin produced hypoglycaemia almost entirely by decreasing hepatic glucose production and had little effect on tissue uptake. These observations suggest that insulin analogues may have actions in vivo that are qualitatively different from those of native insulin and suggest that certain analogues have a predominant action on the liver. This has important therapeutic implications concerning the development of semisynthetic insulins for clinical use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262008
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Covalently-linked insulin dimers: their metabolism and biological effects in vivo as partial competitive antagonists of insulin clearance (1984)
    Springer
    Diabetologia 27 (1984), S. 27-31 
    Details
    ISSN: 1432-0428
    Keywords: Chemically-modified insulins ; insulin structure-function ; bioactivity and metabolism in vivo ; competitive antagonism ; hypoglycaemia ; non-esterified fatty acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The biological properties of three covalently-linked insulin dimers were studied in greyhounds. Constant infusions showed that the plasma distribution kinetics were slower for the dimers than for insulin. The metabolic clearance rates of the three dimers (10.3±0.4, 8.8±0.5, 8.2±0.5 ml· min-1· kg-1; mean ± SEM) were significantly lower than that of insulin (19±0.8 ml · min-1 · kg-1), and their hypoglycaemic effects (11.2%, 3% and 0.3%) were markedly reduced compared with their lipogenic potencies in vitro (80%, 30% and 13%, respectively). A low dose infusion of insulin or an equipotent dose of one of the dimers significantly prolonged the effects of an insulin bolus on plasma glucose but not on non-esterified fatty acids. The apparent distribution space (106.4±11.9 ml/kg) and clearance rate (14.7±0.5 ml · min-1 · kg-1) of an insulin bolus were significantly reduced by one dimer (44.5±8.4 ml/ kg and 10.7±2.8ml·min-1·kg-1) but not by the equipotent insulin infusion (102.7±8.2ml/kg and 16.4±0.07ml· min-1 · kg-1). The apparent partial competitive antagonism of insulin by the dimers that has been reported in vitro can be observed in vivo, in that antagonism of insulin metabolism was directly demonstrated with one of the dimers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253497
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Separation of some nitronaphthalenes by HPLC (1983)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 6 (1983), S. 625-625 
    Details
    ISSN: 0935-6304
    Keywords: Liquid chromatography, HPLC ; Nitronaphthalenes ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240061109
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    13C NMR spectra of 2,3-dihydro-1H-pyrrolo[1,2-c]imidazol-1,3-dione and its thione analoguesSee Ref. 1. (1980)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 13 (1980), S. 89-91 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Analysis of the 13C NMR spectra of a series of 2,3-dihydro-1H-pyrrolo[1,2-c]imidazole derivatives has provided chemical shift data for (˜184 ppm), (˜173.5 ppm), (˜158 ppm) and (˜148 ppm) groups. A full analysis of the 13C chemical shifts of the C atoms of the pyrrole ring and of an N-phenyl substituent is described.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270130203
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...