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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 60 (1982), S. 1385-1392 
    ISSN: 1432-1440
    Keywords: Amino acid transport ; Blood brain barrier ; Capillary permeability ; Cerebrospinal fluid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An attempt is made to evaluate those portions of low molecular hydrophilic solutes that obey apparent passive transfer principles at the blood cerebrospinal fluid (CSF) barrier under steady state conditions. Twenty-four electrolytes, metabolites, and amino acids are determined in serum and CSF obtained simultaneously. The correlation found between the serum/CSF concentration ratios and the molecular radii of most compounds is indicative of the prevalence of passive transfer processes in CSF formation, as has been already demonstrated for proteins. The level of some constituents in the primary filtrate may be secondarily increased by influx from the adjacent extracellular space, e.g. glutamine and creatinine, or decreased by specific uptake from the CSF compartment, e.g. glycine. The CSF levels of all compounds are dependent upon the actual state of the blood CSF barrier as evaluated by the serum/CSF concentration ratios of albumin and α2-macroglobulin. The results do not support the assumption that CSF may be used to test the permeability state of the blood brain barrier propery.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 228 (1982), S. 223-237 
    ISSN: 1432-1459
    Keywords: Central nervous system ; Inflammation ; Humoral immune response ; Cerebrospinal fluid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die drei Immunglobulin-Klassen G, A und M befolgen die Gesetze des passiven Proteintransfers an der Blut-Liquor-Schranke. Deshalb können die aus dem Serum stammenden Anteile mit Hilfe des Permeabilitäts-markers Albumin quantifiziert werden. Die IgG-Fraktionen, die durch gewebsständige Plasmazell-Klone bei verschiedenen entzündlichen Erkrankungen des Zentralnervensystems in den Liquor abgegeben werden, konnten quantitativ bestimmt werden. Bei der multiplen Sklerose und der chronischen Encephalitis ungeklärter Ursache wird überwiegend IgG synthetisiert. Bei den meisten anderen entzündlichen Erkrankungen wird zur gleichen Zeit auch IgA und IgM gebildet, etwa bei der Neurolues und der Herpes-Encephalitis. Bei der durch Zecken übertragenen Meningo-Polyneuritis Bannwarth wird gelegentlich nur IgM und bei der bakteriellen Meningitis nur IgA synthetisiert. Eine lokal gebildete Immunglobulin-Fraktion kann der einzige klinisch-chemische Parameter für das Vorliegen einer chronisch-entzündlichen Erkrankung des Nervensystems sein.
    Notes: Summary The three main immunoglobulin classes obey the basic principles of passive protein transfer at the blood-CSF barrier and the serum-derived portions could therefore be quantified with the help of the permeability marker albumin. The Ig fractions secreted into the CSF by sessile plasma cell clones have been determined in various inflammatory diseases of the central nervous system. The humoral immune response in multiple sclerosis and chronic encephalitis of unknown cause was dominated by IgG antibodies. In most other inflammatory diseases IgA and IgM were concomitantly synthesized, e.g. in neurosyphilis and meningoencephalitis caused by viruses of the herpes group. In tick-borne meningopolyneuritis Bannwarth, only IgM and in bacterial meningitis only IgA may be produced locally. The detection of a secretory immunoglobulin fraction in the CSF may be the sole laboratory parameter in chronic inflammatory processes of the nervous system.
    Type of Medium: Electronic Resource
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