Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Myo-, neuro-, gastrointestinal encephalopathy (MNGIE syndrome) due to partial deficiency of cytochrome-c-oxidase (1987)
    Springer
    Acta neuropathologica 74 (1987), S. 248-258 
    Details
    ISSN: 1432-0533
    Keywords: Myo-, neuro-, gastrointestinal encephalopathy (MNGIE) syndrome ; Cytochrome-c-oxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 42-year-old woman had a 10-year history of external ophthalmoplegia, malabsorption resulting in chronic malnutrition, muscle atrophy and polyneuropathy. Computer tomography revealed hypodensity of her cerebral white matter. A metabolic disturbance consisted of lactic acidosis after moderate glucose loads with increased excretion of hydroxybutyric and fumaric acids. Post-mortem studies revealed gastrointestinal scleroderma as the morphological manifestation of her malabsorption syndrome, ocular and skeletal myopathy with ragged red fibers, peripheral neuropathy, vascular abnormalities of meningeal and peripheral nerve vessels. Biochemical examination of the liver and muscle tissues revealed a partial defect of cytochrome-c-oxidase (complex IV of the respiratory chain). This mitochondrial multisystem disorder may represent a separate entity to be classified between the spectrum of myoencephalopathies and oculo-gastrointestinal muscular dystrophy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688189
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Protein size and cerebrospinal fluid composition (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 1158-1164 
    Details
    ISSN: 1432-1440
    Keywords: Blood-brain-barrier ; capillary permeability ; cerebrospinal fluid ; electrophoresis ; polyacrylamide gel ; gel filtration ; immunoassay ; protein conformation ; Bluthirnschranke ; Kapillarpermeabilität ; Liquor cerebrospinalis ; Polyacrylamidgel-Elektrophorese ; Gelfiltration ; Immunnachweise ; Proteinkonformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Konzentrations-Quotienten zahlreicher Proteine zwischen Serum und Liquor cerebrospinalis korrelieren besser mit den hydrodynamischen Volumen als mit den Molekulargewichten. Die hydrodynamischen Radien wurden der Literatur entnommen, sowie mit Hilfe der analytischen Säulenchromatographie und Gelelektrophorese bestimmt. Diskrepanzen zwischen Molekulargewicht und hydrodynamischem Volumen werden vorwiegend bei den großmolekularen Proteinen gefunden, da hier die Molekülformen stärker variieren. Die Permeabilität der Blut-Liquor-Schranke wird mit der Blut-Lymph-Schranke verglichen, und die Daten werden unter dem Aspekt der derzeitigen Filtrationstheorien diskutiert. Die Basalmembran, die durch Endothelfenster direkten Kontakt mit dem Kapillarlumen erhält, ist der wahrscheinlichste Ort für den Proteindurchtritt an der Blut-Liquor-Schranke.
    Notes: Summary The concentration ratios of several proteins between serum and cerebrospinal fluid (CSF) can be correlated more easily to hydrodynamic volumes than to molweights. Hydrodynamic radii were calculated from literature diffusion data and determined by analytical column chromatography and gel electrophoresis. Discrepancies between molweight and hydrodynamic volume become evident, especially with the high-molecular proteins because of stronger conformational variability in this size range. The permeability of the blood-CSF-barrier is compared to the blood-lymph-barrier and the results are discussed with reference to current views about capillary permeability. The basement membrane, exposed to the capillary lumen by endothelial fenestrations is considered the most likely site of protein passage at the blood-CSF-barrier.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01466734
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Low molecular solutes and the blood cerebrospinal fluid barrier (1982)
    Springer
    Journal of molecular medicine 60 (1982), S. 1385-1392 
    Details
    ISSN: 1432-1440
    Keywords: Amino acid transport ; Blood brain barrier ; Capillary permeability ; Cerebrospinal fluid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An attempt is made to evaluate those portions of low molecular hydrophilic solutes that obey apparent passive transfer principles at the blood cerebrospinal fluid (CSF) barrier under steady state conditions. Twenty-four electrolytes, metabolites, and amino acids are determined in serum and CSF obtained simultaneously. The correlation found between the serum/CSF concentration ratios and the molecular radii of most compounds is indicative of the prevalence of passive transfer processes in CSF formation, as has been already demonstrated for proteins. The level of some constituents in the primary filtrate may be secondarily increased by influx from the adjacent extracellular space, e.g. glutamine and creatinine, or decreased by specific uptake from the CSF compartment, e.g. glycine. The CSF levels of all compounds are dependent upon the actual state of the blood CSF barrier as evaluated by the serum/CSF concentration ratios of albumin and α2-macroglobulin. The results do not support the assumption that CSF may be used to test the permeability state of the blood brain barrier propery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716243
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Chronic HIV encephalitis — I. cerebrospinal fluid diagnosis (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 21-25 
    Details
    ISSN: 1432-1440
    Keywords: Acquired immune deficiency syndrome (AIDS) ; Cerebrospinal fluid ; HIV encephalitis ; HIV-specific antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To establish a reliable procedure for the early detection of central nervous system involvement in HIV infection, paired cerebrospinal fluid and serum samples of 59 patients were analysed. Fifteen were HIV antibody positive without clinical symptoms (stage I), 12 had lymphadenopathy syndrome or AIDS-related complex (stage II), and 32 had AIDS (stage III). Intrathecal synthesis of HIV antibodies was determined by a modified ELISA. Antibodies in CSF and serum were evaluated at identical immunoglobulin G levels to correct for the actual blood-CSF-barrier permeability. A CSF/serum quotient above 1.5 is indicative of intrathecal antibody synthesis, which was found in 47% of the patients in stage I, 67% in stage II, and 84% in stage III. These findings indicate an early and frequent invasion of the CNS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01735208
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Chronic HIV encephalitis — II. clinical aspects (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 26-31 
    Details
    ISSN: 1432-1440
    Keywords: AIDS ; Dementia ; HIV encephalitis ; Neuropsychiatric symptomatology ; Psychological testing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Combined medical, neurological, and serological investigations were carried out in 59 patients infected with human immunodeficiency virus (HIV). In stage I clinical and neuropsychiatric testing did not reveal evidence for HIV encephalitis as diagnosed by local antibody production in CSF. Neuropsychiatric abnormalities, brain atrophy, memory and cognitive impairment reliably indicated HIV encephalitis in later stages. The commonest symptoms were cerebellar and brainstem signs, followed by dementia. Epileptic fits and hemipareses always were associated with cerebral toxoplasmosis. A polyneuropathy was frequently found but other causes have to be considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01735209
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Elektrophorese von Serum und Liquor cerebrospinalis in Polyacrylamid-Gel (1967)
    Springer
    Journal of molecular medicine 45 (1967), S. 371-377 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The protein patterns of normal serum and cerebrospinal fluid after polyacrylamide electrophoresis are described and compared. After densitometric recording the frequency of occurrence and the relative percentage of all those bands are determined, which can be identified by their relative mobility. Cerebrospinal fluid contains two peculiar bands. The level of CSF highmolecular proteins is lower than in serum and penetration rate of these proteins through the barrier between blood and cerebrospinal fluid depends mainly on their molecular weight. The highmolecular parts of haptoglobins 2–1 and 2–2 are detectable only after disturbance of the barrier. Some technical improvements are described, which facilitate standardisation of the method.
    Notes: Zusammenfassung Es werden die Pherogramme normaler Seren und Liquores nach Polyacrylamidgel-Elektrophorese beschrieben und miteinander verglichen. Nach densitometrischer Registrierung wurden Häufigkeit und relativer Anteil aller mit Hilfe des Rf-Wertes identifizierbaren Banden ermittelt und statistisch ausgewertet. Der Liquor enthält zwei typische Banden und ist arm an großmolekularen Proteinen, die je nach Molekulargewicht an der Blut-Liquor-Schranke zurückgehalten werden. Die großmolekularen Anteile der Haptoglobine 2–1 und 2–2 werden im Liquor erst bei einer Schrankenstörung nachweisbar. Es werden einige technische Variationen und Hilfsmittel beschrieben, die eine Standardisierung der Methode erlauben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01738746
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    β Trace-protein as marker for cerebrospinal fluid fistula (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 764-768 
    Details
    ISSN: 1432-1440
    Keywords: Cerebrospinal fluid ; Liquorrhea ; Meningitis ; Brain trauma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The detection of β trace-protein with the help of an easy-to-perform Ouchterlony test is strongly indicative of liquorrhea. The protein has been purified from pooled cerebrospinal fluid and an antiserum has been produced in rabbits. An open CSF fistula was diagnosed in 24 cases and there was no false positive result.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01743251
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Hochmolekulares γG-Paraprotein im Liquor cerebrospinalis bei Plasmocytom (1967)
    Springer
    Journal of molecular medicine 45 (1967), S. 419-422 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A case of myeloma with isolated extra-and intradural localisation is reported, in which a paraprotein could be detected only in the cerebrospinal fluid but not in the serum. The abnormal protein, immunologically a γG-globulin, showed an unusually high sedimentation-rate hitherto not described for a γG-type protein.
    Notes: Zusammenfassung Bei einer Patientin mit einem extra- und intradural wachsenden Plasmocytom wurde nur im Liquor, nicht jedoch im Serum, ein Paraprotein nachgewiesen. Es handelte sich um ein γG-Globulin mit bisher nicht bekannter, ungewöhnlich hoher Sedimentationsgeschwindigkeit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728416
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Monoclonal immunoglobulins on disc electrophoresis (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 1033-1036 
    Details
    ISSN: 1432-1440
    Keywords: Immunoglobulins ; Paraproteins ; Monoclonalγ-Globulins ; Disc Electrophoresis ; Myeloma ; Immunglobuline ; Paraproteine ; Monoclonaleγ-Globuline ; Disc-Elektrophorese ; Myelom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Für den Nachweis mono- und oligoclonaler Immunglobuline wurde eine discelektrophoretische Technik mit transparentem oberem Gel verwendet. Mit dieser Technik können jene Anteile von IgG und IgM sichtbar gemacht und densitometriert werden, d e im oberen Konzentrierungsgel zurückgehalten werden. WährendγA-Globuline im allgemeinen das untere Trenngel erreichen, werden vieleγG-Globuline im transparenten oberen Gel zurückgehalten. In mehreren Seren, die ein einzigesγM-Paraprotein bei der Immunelektrophorese zeigten, wurden jetzt zwei oder drei abnorme Banden sichtbar.
    Notes: Summary A transparent upper gel disc electrophoretic technique was applied for the detection of mono- and oligo-clonal immunoglobulins. This method allows the visualization and densitometrical recording of those proportions of IgG and IgM retained in the upper concentration gel. WhileγA-globulins generally reach the lower separation gel, manyγG-globulins are retained in the transparent upper gel. In several cases, two or three abnormal bands were detected in sera containing a singleγM-paraprotein on immunoelectrophoresis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01486763
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Evidence for different immune responses to HIV in CSF and serum? (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 259-263 
    Details
    ISSN: 1432-1440
    Keywords: Acquired immune deficiency syndrome ; Cerebrospinal fluid antibody quantitation ; Western blot
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of acquired immune deficiency syndrome (AIDS) and a case of AIDS-related complex (ARC) are described. In both instances comparative Western blot analysis of cerebrospinal fluid (CSF) and serum samples show evidence of qualitative differences in antibody-binding patterns to viral polypeptides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01773445
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...