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  • 1
    Electronic Resource
    Electronic Resource
    Increased phencyclidine self-administration due to food deprivation: Interaction with concentration and training conditions (1984)
    Springer
    Psychopharmacology 84 (1984), S. 299-303 
    Details
    ISSN: 1432-2072
    Keywords: Concentration ; Food deprivation ; Food satiation ; History ; Oral drug self-administration ; Phencyclidine ; PCP ; Training condition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Six monkeys were trained to self-administer orally delivered phencyclidine (0.25 mg/ml) under a fixed-ratio 16 (FR-16) schedule. Water was concurrently available under an FR-16 schedule. During initial phencyclidine training, three monkeys were allowed free access to food (food satiation) and three were maintained at 85% of their free-feeding body weights (food deprivation). At the end of the training phase, the food-satiated monkeys were food-deprived. After behavior was stable for ten sessions, all monkeys were food-satiated and tested with a range of phencyclidine concentrations (0.0625–1 mg/ml). They were subsequently food-deprived and tested with concentrations of 0.0312–1 mg/ml, and then they were again food-satiated and tested with 0.0312 and 0.25 mg/ml. The monkeys that were trained to self-administer phencyclidine-maintained responding at lower drug concentrations when later tested while food-satiated. In contrast, monkeys that were trained while food-deprived did not respond for phencyclidine in excess of water at the lower concentrations when later tested while food-satiated. Drug-maintained performance during food deprivation did not change systematically as a function of training condition (food deprivation versus food satiation). These results illustrated a marked interaction between drug concentration and the feeding condition and this interaction was modified by training history.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00555202
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Oral self-administration of phencyclidine analogs by rhesus monkeys: Conditioned taste and visual reinforcers (1982)
    Springer
    Psychopharmacology 78 (1982), S. 116-120 
    Details
    ISSN: 1432-2072
    Keywords: Conditioned reinforcement ; Dissociative anesthetics ; Oral drug self-administration ; PCE ; PCP ; Rhesus monkeys ; Taste ; TCP ; Visual stimuli
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Three monkeys self-administered orally-delivered phencyclidine, 1-(1-phencyclohexyl) piperidine (PCP), N-ethyl-1-phencyclohexylamine (PCE), and 1-[1-(2-thienyl)cyclohexyl]piperidine (TCP) over a wide range of concentrations (0.0156, 0.0312, 0.0625, 0.125, 0.25, and 0.5 mg/ml). Water was also available under a concurrent fixed-ratio (FR) 16 schedule. Drug deliveries were substantially higher than concurrent water deliveries at all concentrations, indicating that the three compounds functioned as effective reinforcers. Maximum liquid deliveries occurred at concentrations of 0.0625 (PCP and TCP) and 0.125 mg/ml (PCE). TCP was much shorter-acting (10–15 min) than PCP (4–6 h) based on observations of severe ataxia at high concentrations. To investigate the conditioned reinforcing effects of taste, a quinine solution (0.088 mg/ml) was substituted for PCP (0.25 mg/ml) in five monkeys. Four monkeys responded for quinine in excess of water for a range of seven to over 30 sessions, while one monkey (M-R) did not show any substantial responding for quinine. With the same five monkeys (treatment order mixed), the effect of visual stimuli was tested by substituting water for PCP while retaining the visual stimuli indicating drug availability. Four monkeys showed increased responding on the side signaling drug for only 0–4 sessions, while one monkey (M-R) showed persistent responding for water on the side with drug stimuli for 29 sessions. These results indicated that taste functioned as an effective conditioned reinforcer, while visual stimuli appeared to be less effective in the oral drug self-administration paradigm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432246
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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