ISSN:
1741-0444
Keywords:
Blood monitoring
;
Catheter-tip pH sensor
;
I.S.F.E.T.
;
Miniature pH sensor
;
Miniature pCO2 sensor
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract A catheter-tip pH sensor was developed for possible clinical and biomedical application, using an ion-sensitive field-effect transistor (i.s.f.e.t.). Its signal drift in buffer solutions during continuous measurement was less than 3 mV in 24 h (equivalent to about 0·05 pH in 24 h). The electric insulation was perfect when soaked in buffer solutions for more than 3 months. A continuousin vivo pH measurement was successfully achieved in nonheparinised arterial blood of a japanese monkey. There was no significant sign of clot formation for 8 hours. It revealed quick responses to respiratory acidosis and alkalosis, and the observed pH values were in accordance with those confirmed by a blood pH analyser. Also, a catheter-tip pCO2 sensor was prepared, using the catheter-tip pH i.s.f.e.t. The response time was 2 min for a 90% change in CO2 tension. The muscle pCO2 monitoring tested with it indicated a similar result to those with medical mass spectrometer.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02441899
Permalink
