ISSN:
1432-0428
Keywords:
Type 2 diabetes
;
HLA-A2
;
age association
;
Pima Indians
;
diabetes
;
genetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In Pima Indians with Type 2 (insulin independent) diabetes mellitus, HLA-A2 allele frequencies were inversely associated with age, (0.72, 0.59, and 0.52 in those less than 35, 35 to 54, and 55 years old and over, respectively). This suggests that there may be a gene closely linked with the HLA-A locus which plays a role in the expression of diabetes in the Pimas by contributing to an earlier age of onset. HLA-A2 was found in 65% of 69 non-diabetic and 81% of 191 diabetic subjects (relative risk = 2.2).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00257786
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