ISSN:
1432-0568
Keywords:
Plasma proteins
;
Embryo
;
Development
;
Immunohistochemistry
;
Sheep
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The distribution of the five plasma proteins that are quantitatively most important during development in the sheep has been studied in embryos of 15 to 21 days gestation. The three primary embryonic layers and tissues that differentiate from them were tested for the presence of α-fetoprotein (AFP), fetuin, albumin, transferrin and α1-antitrypsin using the indirect immunoperoxidase method. Fetuin was the most prominent of these proteins particularly in the developing central nervous system. Fetuin and transferrin appeared early in the differentiating mesoderm and, with albumin and AFP, were detected in tissues originating from all three layers during the course of development. α1-Antitrypsin appeared to have a limited distribution. All five plasma proteins were detected before the establishment of a circulatory system. It is suggested that their appearance in embryonic tissue is related to its stage of development and that they play an important part in early differentiation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00315818
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