ISSN:
1435-1463
Keywords:
Nucleus accumbens
;
dopamine-induced locomotor activity
;
oxotremorine
;
presynaptic receptors
;
6-hydroxydopamine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Behavioural studies were carried out to determine whether central cholinergic mechanisms regulate dopaminergic activity by presynaptic mechanisms as suggested by recentin vitro studies. Bilateral injections of a muscarinic receptor agonist, oxotremorine (4μg), into the nucleus accumbens were found to enhance dopamine-induced locomotor activity. In rats deprived of presynaptic terminals by pretreatment with intraaccumbens injections of 6-hydroxydopamine, oxotremorine did not enhance dopamine-induced locomotor activity but on the contrary produced a marked reduction of locomotor activity. Although dopamine induced locomotor activity could occur in 6-hydroxydopamine treated animals, the muscarinic regulation was dependent on the presence of the intact dopamine terminal and hence a presynaptic receptor may be involved.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01254923
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