ISSN:
1432-1335
Keywords:
N-Methyl-N′-nitro-N-nitrosoguanidine
;
tumors in forestomach
;
glandular stomach
;
liver
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary After 12 oral applications of 80 mg/kg MNNG as a suspension in 30% aqueous ethanol at weekly intervals, 98 Sprague-Dawley rats died with multiple tumors of the forestomach after a medium latency period of 226 days. Histological examination showed generalized papillomatosis developing into keratinizing squamous cell carcinomas with infiltrative growth in 88/98 (89%) animals. Tumorigenic lesions in the glandular stomach ware only observed in 3/98 rats. In two of these animals, mucosal adenocarcinomas were found and in the third a leiomyosarcoma. In about 30% of the animals treated with MNNG, degenerative liver changes were found, especially single cell and focal necroses, cystic alterations, and bile-duct proliferations.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00406933
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