ISSN:
1432-1041
Keywords:
benzodiazepines
;
clorazepate
;
dipotassium clorazepate
;
N-desmethyldiazepam
;
pharmacokinetics
;
smoking
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The pharmacokinetics of N-desmethyl-diazepam was evaluated after oral administration of clorazepate 20 mg to 12 healthy male volunteers (6 smokers; 6 non-smokers), aged 23–29 years. Plasma levels of desmethyldiazepam were measured by gas liquid chromatography. The half life of elimination (t1/2β) was significantly longer in the non-smoking volunteers than in the smokers: 54.7±17.7 versus 29.8±9.9 h (p〈0.05). Peak plasma concentrations (Cmax) were higher in non-smokers than in smokers, 413±106 µg/l and 245±50 µg/l, respectively (p〈0.05). The sedative effect of clorazepate was less severe in smokers than in non-smokers.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00627925
Permalink
