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Digitale Medien

Increased respiratory burst activity of monocytes and polymorphonuclear leukocytes in psoriasis (1982)

SCHOPF, R.E. ; ALTMEYER, P. ; LEMMEL, E.-M.

Oxford, UK : Blackwell Publishing Ltd

British journal of dermatology 107 (1982), S. 0

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ISSN: 1365-2133

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: We studied the respiratory burst activity of peripheral blood monocytes and polymorphonu clear leukocytes (PMN) in eleven patients with psoriasis and eleven healthy controls, using zymosan particles to activate the phagocytes in vitro. The activation of the phagocytes was measured in a luminol-enhanced chemiluminescence (CL) assay. We found a significantly higher respiratory burst activity of both monocytes and PMN in patients with psoriasis compared with the control subjects. The percentages of monocytes in psoriatics did not differ from those of the controls. The higher amount of zymosan-induced CL activity generated in the patient group was unrelated to the age of the individual. Our data indicate increased metabolic reactivity of both monocytes and PMN in psoriasis.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1365-2133.1982.tb00399.x

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Digitale Medien

Morphological and functional findings of fixed phagocytes in psoriatics (1983)

Altmeyer, P. ; Munz, D. L. ; Chilf, G. ; [weitere]

Springer

Archives of dermatological research 275 (1983), S. 95-99

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ISSN: 1432-069X

Schlagwort(e): Phagocytes ; Psoriatics ; Phagocytosis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Twenty-one psoriatics as well as 24 normal healthy adults were studied by functional bone marrow scintigraphy using Tc-99m-labeled human serum albumin millimicrospheres (Tc-99m-HSA-MM). Functional bone marrow scintigraphy is an in vivo test system for the assessment of various functional properties of fixed phagocytes. Of proriatics who had no systemic drug treatment, 59% demonstrated peripheral extension of the bone marrow space, indicating hyperplasia of bone marrow phagocytes. This phenomenon could be observed only in one normal subject who was a high-performance sportsman. Of psoriatics treated with aromatic retinoid, 83% (n=6) demonstrated bone marrow extension, as did 100% (n=3) of psoriatics with cirrhosis of liver. The ‘capacity’ of bone marrow phagocytes to engulf Tc-99m-HSA-MM (‘uptake ratio’) was diminished in 34% of nontreated as well as 66% of psoriatics treated with aromatic retinoid. The phagocytic and proteolytic turnover of Tc-99m-HSA-MM in the bone marrow, spleen, and liver was found to be accelerated in 66% of nontreated psoriatics, normal (83%) or accelerated (17%) in psoriatics treated with aromatic retinoid, and considerably delayed in all of the psoriatics with cirrhosis of liver. Functional bone marrow scintigraphy proved to be an appropriate in vivo test system for revealing abnormalities of fixed phagocytes in psoriatics. Further more, therapeutic effects as well as the influences of preexisting disorders on different phagocyte populations can be assessed.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00412882

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Digitale Medien

Tolerance on corticoids? Guinea pig epithel as an experimental system (1981)

Altmeyer, P. ; Buhles, N.

Springer

Archives of dermatological research 271 (1981), S. 3-9

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ISSN: 1432-069X

Schlagwort(e): Corticosteroids ; Antiacanthogenic effect ; Carrier reaction ; Corticosteroide ; antiacanthogene Wirkung ; Grundlagen-effekt

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Beschreibung / Inhaltsverzeichnis: Zusammenfassung Anhand des beschriebenen Testverfahrens läßt sich der bekannte antiacanthogene Effekt topisch applizierter Corticosteroide exakt erfassen und quantifizieren. Eine 0,1% Clobetasol-17-propionat-Lösung induziert nach 28tägiger Behandlungsperiode einen antiacanthogenen Effekt von 27,5%, nach 84 Tagen eine Epithelverdünnung von 23,7% und nach 118 Tagen von 39%. Somit läßt sich aus den vorliegenden Ergebnissen keine Steroidtoleranz des Meerschweinchenepithels ableiten.

Notizen: Summary The antiacanthogenic effect of topical applied steroids is well known and maybe exactly assessed and quantified by means of the test procedure described. A 0.1% clobetasol-17-propionate solution induces an antiacanthogenic effect of 27.5% after a 28-day treatment period. After 84 days, the skin further treated with the corticosteroid shows an anticanthogenic effect of 23.7% and after 118 days of 39%. A steroid tolerance of epithelial layer on guinea pig skin cannot be derived from our results.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00417382

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