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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 271 (1981), S. 3-9 
    ISSN: 1432-069X
    Keywords: Corticosteroids ; Antiacanthogenic effect ; Carrier reaction ; Corticosteroide ; antiacanthogene Wirkung ; Grundlagen-effekt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Anhand des beschriebenen Testverfahrens läßt sich der bekannte antiacanthogene Effekt topisch applizierter Corticosteroide exakt erfassen und quantifizieren. Eine 0,1% Clobetasol-17-propionat-Lösung induziert nach 28tägiger Behandlungsperiode einen antiacanthogenen Effekt von 27,5%, nach 84 Tagen eine Epithelverdünnung von 23,7% und nach 118 Tagen von 39%. Somit läßt sich aus den vorliegenden Ergebnissen keine Steroidtoleranz des Meerschweinchenepithels ableiten.
    Notes: Summary The antiacanthogenic effect of topical applied steroids is well known and maybe exactly assessed and quantified by means of the test procedure described. A 0.1% clobetasol-17-propionate solution induces an antiacanthogenic effect of 27.5% after a 28-day treatment period. After 84 days, the skin further treated with the corticosteroid shows an anticanthogenic effect of 23.7% and after 118 days of 39%. A steroid tolerance of epithelial layer on guinea pig skin cannot be derived from our results.
    Type of Medium: Electronic Resource
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