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  • 1
    Electronic Resource
    Electronic Resource
    Structure of propionamide at 123 K (1982)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 38 (1982), S. 660-662 
    Details
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567740882003707
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    General and selective inhibition of pancreatic enzyme discharge using a proteinase inhibitor (FOY-305) (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 406-411 
    Details
    ISSN: 1432-1440
    Keywords: Pancreatic secretion ; Intracellular transport ; Proteinase inhibitor ; Two-dimensional gel electrophoresis ; FOY-305
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The guanidino acid esters (FOY, FOY-305) represent a new class of potent proteinase inhibitors and are thought to have a beneficial effect on the course of acute pancreatitis. Because of their structure and low molecular size they might enter cells and interfere with cellular processes. To test this possibility in the case of the exocrine pancreas a series of in vivo and in vitro studies was carried out to analyse intracellular transport and discharge of pancreatic enzymes in the presence of FOY-305. The infusion of FOY-305 to conscious rats led to a transient inhibition of protein and enzyme discharge from the cannulated pancreas accompanied by lower serum enzyme levels and increased enzyme content in the pancreas. An identical inhibition of discharge of newly synthesized proteins was observed in vitro in the presence of 1 µM FOY-305. The analysis of the release of individual enzymes using separation on two-dimensional gels showed a pronounced inhibition of mainly the release of acidic proteins. FOY-305 not only interfered with discharge of serine proteinases (trypsinogen, chymotrypsinogen, proelastase) but also with procarboxypeptidases and lipase. It was concluded that FOY-305 enters the acinar cell and due to an unspecific binding to acidic proteins interferes with the intracellular transport of individual enzyme proteins during their passage through the membrane-bound cellular compartments. This charge-dependent effect is independent of the inhibitory effect on enzymatic activity of serine proteinases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01742297
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    319. Modifikationen des „Pfeffer-Modells” zur Erzeugung der hämorrhagischen Pankreatitis: Pathogenetische und therapeutische Aspekte (1982)
    Springer
    Langenbeck's archives of surgery 358 (1982), S. 585-585 
    Details
    ISSN: 1435-2451
    Keywords: Pancreatitis ; Pfeffer-model modification ; Pathogenesis ; Lethality ; Pankreatitis ; Pfeffermodell-Modifikation ; Pathogenese ; Letalität
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Modifikationen des Pfeffermodells mit 100 cm langen Duodenalloop und frühzeitiger Wiedereröffnung des 20cm langen Duodenalloop - Occlusion durch Boeremaknopf - führen zur hämorrhagisch nekrotisierenden Pankreatitis. Letalität des kurzen geschlossenen Loop: 100 %, überlebenszeit 27 h. Deutliche Senkung der Letalität und Verlängerung der überlebenszeit durch die Modekationen. Der schon nach 12 h nachweisbaren intracelluldren Bakterienbesiedlung im Pankreas kommt eine causalpathogenetische Bedeutung dieses Krankheitsablaufes zu. Das Modell ist für Studien plastischer geworden.
    Notes: Summary Modification of the Pfeffer model with a duodenal loop of 100cm - the occlusion made by the Boerema button - and the early reopening of the 20-cm-long duodenal loop result in hemorrhagic necrotic pancreatitis. There is 100 % lethality with the short closed loop, the survival time being only 27 h. Through modifications lethality is clearly reduced and the survival time extended. The endocellular bacterial flora in the pancreas - already identifiable after 12 h - is of causal pathogenetic importance. The model is clearly better for studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01272065
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    Paper (German National Licenses)
    Fulltext
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