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  • 1
    Electronic Resource
    Electronic Resource
    Knochenmarktransplantation bei Patienten mit Leukämien (1982)
    Springer
    Journal of molecular medicine 60 (1982), S. 1279-1287 
    Details
    ISSN: 1432-1440
    Keywords: Bone marrow transplantation ; Acute leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Between October 1979 and March 1982, bone marrow transplantations were performed by the Tübingen Group for BMT on 19 patients with acute leukemia in remission and on one patient with chronic myelocytic leukemia in chronic phase. The conditioning regimen consisted of 2×60 mg cyclophosphamide/kg and 10 Gy whole-body irradiation with the linear accelerator. The lung dose was limited by shielding to 8 Gy. In 15 patients, the bone marrow cell suspension of the donor was preincubated with antihuman T-cell globulin (AHTCG) for prophylaxis of graft-versus-host disease (GVHD). All patients showed prompt engraftment of donor cells with good hemopoietic function and complete chimerism. Under reverse isolation in sterile units, no severe bacterial or fungal infections were seen in the phase of bone marrow aplasia. Twelve in twenty patients survived between 25 and 900 days. A severe GVHD was seen only in two patients — one after preincubation with AHTCG. One patient died from relapse of his leukemia, another patient had a testicular relapse which was treated with local radiotherapy. Major problems were seen with chronic GVHD (six patients) and infectious complications, most importantly interstitial pneumonia, in the late post-transplant period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727484
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Bone marrow transplantation for acute leukemia in second or subsequent remission (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 1081-1085 
    Details
    ISSN: 1432-1440
    Keywords: Bone marrow transplantation ; Acute leukemia ; Recurrent leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-one patients with acute leukemia in second to fifth remission were treated with bone marrow transplantation: 19 patients with transplants from HLA-matched siblings and two with transplants from identical twins. Twelve patients survived from 15 to 1,625 days after transplantation: six of 11 in the ALL group and six of 10 in the AML group. Recurrence of leukemia after marrow transplantation occurred in five patients. The cause of death in five patients was infection, in two patients combined with graft-versushost disease. Long-term disease-free survival can probably be achieved in 30%–35% of all patients with acute leukemia who receive a marrow transplant in second or subsequent remission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711377
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    23 a. Standpunkt des Strahlentherapeuten (1981)
    Springer
    Langenbeck's archives of surgery 355 (1981), S. 167-172 
    Details
    ISSN: 1435-2451
    Keywords: Irradiation reactions ; Radiation damages ; Irradiation planning ; Strahlenreaktion ; Strahlenschaden ; Bestrahlungsplanung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Jede Strahlentherapie erfordert das Abwägen zwischen Heilungschance und möglichem Komplikationsrisiko. Neben kalkulierbaren Nebeneffekten erschweren nicht abschätzbare Faktoren diese Entscheidung. - Die Wirkungsweisen der verschiedenen Strahlenqualitäten werden erörtert und die dabei möglichen Gewebsreaktionen aufgezeigt. Es ist zu erwarten, daß durch die Weiterentwicklung der technischen Möglichkeiten, insbesondere durch die individuelle Bestrahlungsplanung mittels Computertomographie in Zukunft echte Strahlenschäden vermieden werden können.
    Notes: Summary In radiotherapy, the chance of recovery must always be weighed against the possible risk of complication. The decision is complicated not only by certain calculable side-effects, but also by unknown factors. The effects of various types of radiation and possible tissue reactions are discussed. With further technical progress, particularly that in the field of individual irradiation planning by means of CT, typical radiation damage can probably be totally avoided in the future.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01286835
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    Paper (German National Licenses)
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