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  • 1
    Electronic Resource
    Electronic Resource
    Changes in the compact myelin of single internodes during axonal atrophy (1984)
    Springer
    Acta neuropathologica 63 (1984), S. 313-318 
    Details
    ISSN: 1432-0533
    Keywords: Axonal atrophy ; Internodal myelin ; Light and electron microscopy ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Distal axonal atrophy was produced by proximal constriction of the tibial nerve in the rabbit. Transverse sections were studied by light and electron microscopy at 10 μm intervals along individual internodes of both atrophic and normal tibial nerve fibres. During axonal atrophy there were marked changes in axonal configuration at different levels within the territory of a single Schwann cell. These resulted in changes in the lengths of the axon perimeter and myelin spiral, without causing any alteration in the numbers of myelin lamellae or their spacing. Comparable changes in axon perimeter and myelin spiral length were seen in transverse sections through the paranodal and nuclear regions of normal fibres. These results show that local variations in axonal calibre or shape are associated with appropriate adjustments to the length of the myelin spiral, without a change in the number of lamellae, and thus of sheath thickness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687339
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The pathology of allyl chloride neurotoxicity in mice (1981)
    Springer
    Acta neuropathologica 55 (1981), S. 125-133 
    Details
    ISSN: 1432-0533
    Keywords: Allyl chloride ; Neurotoxicity ; Axonopathy ; Peripheral nerves
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Allyl chloride is known to produce a neuropathy in man after occupational exposure to its vapour. The present study describes the neuropathy which develops in mice given allyl chloride by mouth. Mice were dosed three times weekly with 300 or 500 mg/kg allyl chloride for periods from 2–17 weeks. Functional disability was observed in some animals. Apart from evidence of focal kidney damage in 70% of dosed mice, pathological changes were restricted to the nervous system. Nerve fibre degeneration was found in many peripheral nerves and in roots, tending to be more marked distally and to affect more motor than sensory nerves. Degenerated fibres were also found in dorsal, ventral and lateral columns of the spinal cord. Males were more severely affected than females. Increased numbers of filaments were an early axonal change, occurring multifocally and apparently preceding axonal degeneration. No neuronal death was observed, but occasional anterior horn and dorsal root ganglion cells showed some morphological changes. Vacuolated lesions mainly due to swelling of astrocytes and their processes were found in the ventral horn in cervical and lumbar regions of spinal cord. Animals appeared to become tolerant to allyl chloride after continuous dosing. This neuropathy appears to be a centralperipheral distal type of axonopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00699237
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Bismuth abundance anomaly in a Hg—Mn star (1982)
    [s.l.] : Nature Publishing Group
    Nature 299 (1982), S. 535-536 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The IUE spectra were processed at the University College London Starlink node using the standard analysis programs STAK and TRAK. In Fig. 1 we compare the region of the Bi II resonance line at 1,436.83 A in SWP images of three stars: HR7775, i CrB (Hg-Mn) and v Cap (normal B9.5 V). The spectra of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/299535a0
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    Paper (German National Licenses)
    Fulltext
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