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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of bredinin in renal transplant patients (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 457-461 
    Details
    ISSN: 1432-1041
    Keywords: bredinin ; immunosupressive agent ; pharmacokinetics ; renal transplant patients ; renal function ; absorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A pharmacokinetic study of bredinin, a new immunosupressive agent, was carried out in 28 renal transplant patients. Serum bredinin concentration-time curves were analyzed using a one-compartment open model with a first order absorption process. The peak serum bredinin level appeared 2.4 h after oral administration of bredinin 50–200 mg. The calculated mean peak serum level was 0.852 µg/ml/mg/kg, when the dose was adjusted to the body weight of the patient. In the dosage range used of 0.85–4.46 mg/kg, a linear relationship was observed between the dose and the peak serum bredinin level. The elimination rate of bredinin from serum was dependent on kidney function, and the elimination rate constant was well correlated with the endogenous creatinine clearance. No circadian rhythm was apparent in the elimination rate constant. The absorption rate of bredinin from the gastrointestinal (GI) tract was affected by GI diseases. The need for dosage adjustment based on the renal function of the transplant patient is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609886
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Monoclonal antibody specific for capsid antigen of Epstein-Barr virus (1983)
    Springer
    Medical microbiology and immunology 171 (1983), S. 225-231 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A hybrid cell line (Cl-5l) producing an anti-capsid antibody was obtained by fusion of mouse myeloma cells with spleen cells from mice immunized with purified P3HR-1 Epstein-Barr virus (EBV). Immunofluorescence showed that the Cl-5l antibody reacted with the cytoplasm and the nucleus of P3HR-1 and B95-8 cells, but not with Raji, BJAB, Molt-4, and superinfected Raji cells in the presence of cytosine arabinoside (Ara-C). The viable P3HR-1 and B95-8 cells were not stained nor was the viral infectivity neutralized. The Cl-5l antibody immunoprecipitated 123,000 and 120,000 dalton polypeptides of P3HR-1 and B95-8 cells, respectively, and both were sensitive to phosphonoacetic acid. Specific reactions were not evident with extracts of Raji cells and superinfected Raji cells in the presence of Ara-C. An analysis of the purified virus particles showed that this antibody recognized a capsid component of EBV.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02123496
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Analysis of the transformation of human lymphocytes by Epstein-Barr virus III (1981)
    Springer
    Medical microbiology and immunology 170 (1981), S. 19-26 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract T-cell depleted human cord blood lymphocytes were exposed to P3HR-1 strain of Epstein-Barr virus (EBV) and simultaneous observations of immunofluorescence, cellular morphology, and autoradiography were carried out in individual cells. Soon after infection, nuclear antigen (EBNA) synthesis, blastogenesis, and DNA synthesis occurred, as was previously observed in B95-8 strain EBV infection. Although mitosis followed with characteristic cell aggregate formation, the cell proliferation was temporary and death followed in about 2 weeks. The synthesis of the early antigens (EA) and the viral capsid antigen (VCA) were not significant. These findings seem to indicate that the strain P3HR-1 EBV is capable of inducing early events of transformation in primary human B-lymphocytes, but the cells infected in this way have a short life span.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02123793
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Atomization and determination of traces of copper, manganese, silver and lead in microamounts of steel. atomic-absorption spectrometry using direct atomization of solid sample in a graphite-cup cuvette (1982)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 312 (1982), S. 109-113 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Summary The electrothermal atomic-absorption spectrometry of copper and manganese in steels, which are comparatively difficult to atomize, has been studied with direct atomization from one grain of solid sample. The absorption intensities and evaporation rates of these elements are dependent on the atomization temperature and their diffusion rate in iron. Evaporation rates of copper and manganese from steel are dependent on the weight of sample taken, because of the slow diffusion rate and high atomization temperature. The surface area of a sample plays an important role for the evaporation of trace elements from solid samples. Optimum conditions for their atomization include repetitive atomization at about 2080° C. On the other hand, easily atomizable elements such as silver and lead are determined by a single heating step. Evaporation of these elements is also affected by the surface area of the solid sample. Detection limits are 0.1 ng for Cu, 0.04 ng for Mn and 0.008 ng for Ag.
    Notes: Zusammenfassung Zur direkten Spurenanalyse von Kupfer, Mangan, Silber und Blei in Stählen wird eine normale Graphit-Becherküvette verwendet, mit deren Hilfe kleine Proben direkt in fester Form eingebracht werden können. Die Absorptionsintensitäten und Verdampfungsgeschwindigkeiten hängen von der Temperatur und der Diffusionsgeschwindigkeit im Eisen ab. Die Oberfläche der Proben spielt eine wichtige Rolle bei der Verdampfung von Spurenelementen aus Festkörpern. Mehrfache Aufschmelzung für Kupfer und Mangan ist erforderlich bei Temperaturen von etwa 2080° C. Leicht atomisierbare Elemente (Ag, Pb) können mit einer einmaligen Heizstufe bestimmt werden. Die Verdampfung wird in diesem Fall auch von der Oberflächengröße der Probe beeinflußt. Die Nachweisgrenzen betragen 0,1 ng für Cu, 0,04 ng für Mn und 0,008 ng für Ag.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00467723
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Trace analysis of zinc and bismuth in high purity tin by polarized zeeman atomic absorption spectrometry with direct atomization of solid samples (1983)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 315 (1983), S. 34-37 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Summary Traces of zinc and bismuth in small amounts of high purity tin (0.5 ∼ 25 mg) were determined by polarized Zeeman AAS with direct atomization of a solid sample in a electrothermal graphite-cup cuvette. Standard solutions of zinc and bismuth were employed for the calibration curve. Absorption intensities (peak areas of the absorption signals) for zinc and bismuth were not influenced by the residual tin in a graphite-cup cuvette, up to 25 mg for zinc and up to 10 mg for bismuth. The relative standard deviations of analytical results were 9 ∼ 43% for 0.002 ∼ 0.05 ppm of zinc and 5 ∼ 10 % for 0.06 ∼ 1.3 ppm of bismuth. Detection limits were 0.012 ng for zinc and 0.03ng for bismuth. These values correspond to 0.0005 ppm of zinc in 25 mg of tin and 0.03 ppm of bismuth in 10 mg of tin. Time (incl. weighing the sample) required for analyzing one sample was about 5 min.
    Notes: Zusammenfassung Spuren Zink (0,002 ∼ 0,05 ppm) und Bismut (0,06 ∼ 1,3 ppm) wurden in reinem Zinn mit polarisierter Zeeman-AAS bestimmt. Eine kleine Menge der Probe (0,5 ∼ 25 mg) in fester Form wurde direkt mit Hilfe einer elektrothermischen Graphit-Becherküvette atomisiert. Eichkurven von Zn und Bi wurden mit Standardlösungen aufgestellt. Sn in der Graphit-Becherküvette beeinflusst die Absorptionsintensität von Zn bis zu 25 mg und von Bi bis zu 10mg nicht. Die relative Standardabweichung betrug 9 ∼ 43% für 0,002 ∼ 0,05 ppm Zn und 5 ∼ 10% für 0,06 ∼ 1,3 ppm Bi, die Nachweisgrenzen 0,012 ng für Zn und 0,03ng für Bi. Diese Werte entsprechen 0,005 ppm Zn in 25 mg Sn und 0,03 ppm Bi in 10 mg Sn. Die Durchführung einer Analyse benötigt etwa 5 min.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00476402
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    Paper (German National Licenses)
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