ISSN:
1435-2451
Keywords:
Bile acids
;
Colonic cancer
;
Preternatural anus
;
Pathogenetic considerations
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Description / Table of Contents:
Zusammenfassung 120–200 Tage nach Anlage einer doppelläufigen Colostomie entwickeln Wistar-Ratten im Bereich des Anus praeter spontan Adenocarcinome. Im Hinblick auf die mögliche Bedeutung von Gallensäuremetaboliten für die Pathogenese des Coloncarcinoms wurde an colostomierte Ratten Chenodesoxycholsäure verfüttert. Bereits 60 Tage nach Colostomie fand sich bei 3 von 10 Ratten eine maligne Transformation der Dickdarmschleimhaut im Bereich des Kunstafters. Die an diesem neuartigen Tiermodell gewonnene Beobachtung läßt eine cocarcinogene Aktivität der Gallensäuren bzw. ihrer bakteriellen Metaboliten vermuten.
Notes:
Summary Wistar rats spontaneously develop adenomatous polyps with cell dysplasia (Figs. 2 and 3) and finally, adenocarcinomas (Fig. 1) at the preternatural anus 120–200 days after the formation of a double loop colostomy. With respect to the potential significance of bile acid metabolites in the pathogenesis of colonic cancer, the effect of continuous oral administration of chenodeoxycholic acid (CDCA) on the rate of carcinomas at the preternatural anus was examined. This animal model gained special interest because until now the possible cocarcinogenic rule of bile metabolites was generally demonstrated only after additional administration of chemical carcinogens like dimethylhydracin or nitrosoguanidin. Of ten rats in the CDCA-treated group, three already showed a malignant transformation to adenocarcinomas at the preternatural anus 60 days after a colostomy (Fig. 4). Apparently the alteration of natural ecologic conditions diminishes the resistance against external and internal carcinogenic or cocarcinogenic agents. The rule of bile acid metabolites is discussed under these circumstances.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01237636
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